公开(公告)号：US20150187558A1

公开(公告)日：2015-07-02

申请号：US14142240

申请日：2013-12-27

Applicant: IMRA AMERICA, INC.

Inventor： Andrew A. MILLS ,  Martin E. FERMANN ,  Jiahui PENG ,  Robert J. LEVIS

IPC: H01J49/16 ,  G01N30/96 ,  G01N33/483 ,  G01N33/50 ,  G01N33/68 ,  G01N33/92 ,  G01N33/94 ,  G01N33/02 ,  H01J49/04 ,  G01N33/49

CPC classification number: G01N33/02 ,  G01N30/7266 ,  G01N33/4833 ,  G01N33/49 ,  H01J49/0463

Abstract: The present invention relates to a mass spectrometer system, which combines laser desorption with pulse bursts comprising a train of ultrashort pulses and electrospray ionization. The pulse separation between individual pulses within the pulse burst is selected such that transient phenomena on an irradiated sample do not fully relax between individual pulses. Pulses with pulse widths ranging from fs to sub ns are conveniently implemented. The pulse widths can be selected to allow for multi-photon excitation of a sample while at the same time minimizing heat accumulation in a sample. Low cost laser systems such as fiber lasers can be configured to generate appropriate pulse bursts. The technique is suitable for mass spectrometry imaging with high spatial resolution. The laser system can serve as an electronic clock to which the whole mass spectrometry system or mass spectrometry imaging system is synchronized.

Abstract translation: 本发明涉及一种将激光解吸与脉冲串组合在一起的质谱仪系统，脉冲串包括一串超短脉冲串和电喷雾电离。 选择脉冲脉冲串内的各个脉冲之间的脉冲间隔，使得被照射样品上的瞬态现象在各个脉冲之间不完全松弛。 脉冲宽度范围从fs到sub ns的脉冲是方便的。 可以选择脉冲宽度以允许样品的多光子激发，同时最小化样品中的热积聚。 诸如光纤激光器的低成本激光系统可被配置成产生适当的脉冲串。 该技术适用于具有高空间分辨率的质谱成像。 激光系统可以用作整个质谱系统或质谱成像系统同步的电子时钟。