公开(公告)号：US20170283479A1

公开(公告)日：2017-10-05

申请号：US15513762

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DIMARCHI ,  Binbin KOU ,  Fa ZHANG ,  John P. MAYER

IPC: C07K14/62 ,  A61K38/28

CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/28 ,  A61K47/00 ,  A61K47/54 ,  A61K47/543 ,  A61K47/6911

Abstract: Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

公开(公告)号：US20230285578A1

公开(公告)日：2023-09-14

申请号：US17925477

申请日：2021-05-25

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DIMARCHI ,  Fa ZHANG

IPC: A61K47/64 ,  C07K14/635 ,  A61K9/20 ,  A61P5/18 ,  A61P19/10

CPC classification number: A61K47/64 ,  A61K9/20 ,  A61P5/18 ,  A61P19/10 ,  C07K14/635

Abstract: A novel derivative of parathyroid hormone is provided that has an extended time of action relative to known native parathyroid hormone agonist peptides, while minimizing excessive action shortly after administration. Compositions comprising the novel parathyroid hormone conjugates can be used to treat hypoparathyroidism and osteoporosis.