公开(公告)号：US11242516B2

公开(公告)日：2022-02-08

申请号：US16137925

申请日：2018-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Pei-Yi Tsai ,  Chih-Hung Chen ,  Yi-Hung Lin ,  Chih-Chieh Huang ,  Hsin-Hsin Shen ,  Liang-Yin Ke ,  Chu-Huang Chen

IPC: C12N11/12 ,  A61M1/34 ,  C12N11/14 ,  C12M1/00 ,  C12N11/10

Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.