公开(公告)号：US20180219257A1

公开(公告)日：2018-08-02

申请号：US15878783

申请日：2018-01-24

Applicant: Industrial Technology Research Institute

Inventor： Lee-May Huang ,  Chih-Hung Chen

IPC: H01M10/0567 ,  H01M10/054 ,  H01M10/0568 ,  H01M10/0569 ,  H01M4/133 ,  H01M4/46 ,  H01M4/66 ,  H01M4/587 ,  H01M2/16

CPC classification number: H01M10/0567 ,  H01M2/1613 ,  H01M2/1626 ,  H01M2/1653 ,  H01M2/1686 ,  H01M4/133 ,  H01M4/134 ,  H01M4/463 ,  H01M4/587 ,  H01M4/661 ,  H01M4/663 ,  H01M10/054 ,  H01M10/0568 ,  H01M10/0569 ,  H01M2300/0022 ,  H01M2300/0028 ,  H01M2300/0031 ,  H01M2300/0045

Abstract: An aluminum-ion battery is provided. The aluminum-ion battery includes a positive electrode, a separator, a negative electrode, and an electrolyte composition. The negative electrode is separated from the positive electrode by a separator. The electrolyte composition is disposed between the positive electrode and the negative electrode. The electrolyte composition includes an aluminum halide, a solvent and a compound of Formula (I) wherein R1 is C1-8 alkyl group or C1-8 fluoroalkyl group; and n is 2, 3, 4, or 5. The sum of the aluminum halide and the solvent is 100 parts by weight. The compound of Formula (I) has a weight that is equal to or greater than 0.5 parts by weight and less than 5 parts by weight.

公开(公告)号：US20230203474A1

公开(公告)日：2023-06-29

申请号：US18088628

申请日：2022-12-26

Applicant: Industrial Technology Research Institute

Inventor： Ming-Chun Lin ,  Hui-Ling Cheng ,  Chun-Ting Lai ,  Hua-Cheng Chou ,  Wei-Chin Huang ,  Chih-Hung Chen ,  Shu-Feng Chen

IPC: C12N15/10 ,  C07H21/00 ,  C07D491/18 ,  C07H1/06

CPC classification number: C12N15/1006 ,  C07D491/18 ,  C07H1/06 ,  C07H21/00

Abstract: A compound, a solid carrier including the same and a method for preparing a nucleic acid are provided. The compound has a structure represented by Formula (1) as follows.





In Formula (1), the definition of Y1, Y2, Z and * are the same as defined in the detailed description.

公开(公告)号：US11242516B2

公开(公告)日：2022-02-08

申请号：US16137925

申请日：2018-09-21

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Pei-Yi Tsai ,  Chih-Hung Chen ,  Yi-Hung Lin ,  Chih-Chieh Huang ,  Hsin-Hsin Shen ,  Liang-Yin Ke ,  Chu-Huang Chen

IPC: C12N11/12 ,  A61M1/34 ,  C12N11/14 ,  C12M1/00 ,  C12N11/10

Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.

公开(公告)号：US10696638B2

公开(公告)日：2020-06-30

申请号：US16206000

申请日：2018-11-30

Applicant: Industrial Technology Research Institute

Inventor： Chih-Hung Chen ,  Yi-Hsun Chen ,  Jui-Wen Huang ,  Kuo-Kuei Huang ,  Chih-Peng Liu ,  Chrong-Shiong Hwang

IPC: C07D217/02 ,  A61K31/472 ,  A61P27/02 ,  A61K31/4725 ,  A61K9/08 ,  A61K9/00

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —C(═Z)—, wherein Z is N—CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —NH2, —CN, —OH, —O-alkyl, —O-aryl, —COOH, —COOR4, —CONHR4, —CONHCH2-aryl, —CONR4CH2-aryl, —NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -alkyl-ONO2, alkyl-ONO2, —OCOOR4, —O(C═O)-aryl, —CHR4OH, —CH2OH, —CH2O(C═O)-aryl, —CH2O(C═O)—R4, —CHR4O(C═O)-aryl, —CHR4O(C═O)—R4, unsaturated carboxylic ester, substituted alkynyl, —NHSO2R4, —SO2R4, —SO2NHR4, or —SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4 and R5 are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, —S(O)0-2-(alkyl-NR6R7). R1, R2 and R3 are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO2, or NR8R9.