公开(公告)号：US20210290710A1

公开(公告)日：2021-09-23

申请号：US17138610

申请日：2020-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Kuei-Chang LI ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Yen-Wu HSIEH ,  Shu-Fang WEN

IPC: A61K36/074 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61K31/575 ,  A61P25/28 ,  A61P25/20 ,  A61P1/00

Abstract: A composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US20220249395A1

公开(公告)日：2022-08-11

申请号：US17727301

申请日：2022-04-22

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW ,  Pei-Hsin LIN

IPC: A61K31/047 ,  A61K31/215 ,  A61K31/335 ,  A61K9/50 ,  A61K31/352 ,  A61K9/00 ,  A61K31/045 ,  A61P37/00 ,  A61P25/28 ,  A61K9/08 ,  A61K9/14 ,  A61K31/075 ,  A61K31/122 ,  A61K31/222 ,  A61K31/343 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, O2CH3, —(C═O)—CH3 or (C═O)—NH2.

公开(公告)号：US20190183949A1

公开(公告)日：2019-06-20

申请号：US15845394

申请日：2017-12-18

Applicant: Industrial Technology Research Institute

Inventor： I-Hong PAN ,  Wei-Hsuan HSU ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Hsin-Chieh WU

IPC: A61K36/04 ,  A61P25/24 ,  A61P25/28 ,  A61P25/22

CPC classification number: A61K36/04 ,  A61K8/97 ,  A61K35/00 ,  A61K2236/00 ,  A61K2236/19 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

Abstract: The present disclosure provides a method for treating and/or alleviating nervous diseases, including: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.

公开(公告)号：US20190000776A1

公开(公告)日：2019-01-03

申请号：US16023940

申请日：2018-06-29

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW

IPC: A61K31/047 ,  A61K31/222 ,  A61K31/075 ,  A61K31/122 ,  A61K31/343 ,  A61K9/14 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40 ,  A61P25/28 ,  A61P37/00

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, —SO2CH3, —(C═O)—CH3 or —(C═O)—NH2.

公开(公告)号：US20240165181A1

公开(公告)日：2024-05-23

申请号：US18327583

申请日：2023-06-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Kuei-Chang LI ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Yen-Wu HSIEH ,  Shu-Fang WEN

IPC: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

CPC classification number: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US20220339137A1

公开(公告)日：2022-10-27

申请号：US17860952

申请日：2022-07-08

Applicant: Industrial Technology Research Institute

Inventor： I-Hong PAN ,  Ming-Han LI ,  Kai-An CHUANG ,  Shu-Fang WEN

IPC: A61K31/353 ,  A61K9/00 ,  A61P17/06 ,  A61P29/00 ,  A61K9/06

Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.

公开(公告)号：US20210290557A1

公开(公告)日：2021-09-23

申请号：US17126901

申请日：2020-12-18

Applicant: Industrial Technology Research Institute

Inventor： Yu-Feng HUANG ,  Chu-Hsun LU ,  Kuo-Kuei HUANG ,  I-Hong PAN

IPC: A61K9/50 ,  A61K9/00 ,  A61K9/48 ,  A61K31/047 ,  A61K31/235 ,  A61K31/216 ,  A61K31/075 ,  A61K31/122 ,  A61K31/343

Abstract: A multi-particulate pharmaceutical composition includes mixture pellets including at least two of the following pellets: a first immediate-release pellet, a sustained-release pellet, an enteric-release pellet and an enteric coated sustained-release pellet.

公开(公告)号：US20240216454A1

公开(公告)日：2024-07-04

申请号：US18396942

申请日：2023-12-27

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  I-Huang LU ,  Shu-Fang WEN

IPC: A61K36/28 ,  A61P17/00

CPC classification number: A61K36/28 ,  A61P17/00 ,  A61K2236/331 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53

Abstract: A method for treating dermatitis is provided. The method for treating dermatitis includes administering an effective amount of an Adenostemma lavenia extract or administering an effective amount of a pharmaceutical composition for treating dermatitis including an Adenostemma lavenia extract to a subject in need thereof, wherein the dermatitis comprises atopic dermatitis or contact dermatitis.

公开(公告)号：US20230201291A1

公开(公告)日：2023-06-29

申请号：US17560487

申请日：2021-12-23

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin Jan YAO ,  Yu-Wen CHEN ,  Chu-Hsun LU ,  I-Hong PAN ,  Wen-Yin CHEN ,  Tsung-Lin YANG ,  Angela GOH

IPC: A61K36/287 ,  A61P29/00

CPC classification number: A61K36/287 ,  A61P29/00 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/31 ,  A61K2236/53 ,  A61K2236/55

Abstract: A method for extracting flavone aglycones in Chrysanthemum morifolium is provided. The method includes: (a) immersing a Chrysanthemum morifolium raw material in water or an aqueous solution to perform an immersion procedure for 3.5 hours or more to obtain an immersion sample; and (b) adding an extraction solvent to the immersion sample to perform an extraction procedure 5-60 minutes to obtain an extract. The Chrysanthemum morifolium raw material includes at least one of the following parts of Chrysanthemum morifolium: whole plant, roots, stems, leaves and flowers.

公开(公告)号：US20210322496A1

公开(公告)日：2021-10-21

申请号：US17365207

申请日：2021-07-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Wei-Hsuan HSU ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Hsin-Chieh WU

IPC: A61K36/04 ,  A61K35/744 ,  A61K8/9789 ,  A61Q19/08 ,  A61K35/747 ,  A23L33/105 ,  A23L33/00 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24

Abstract: A method for treating and/or alleviating nervous diseases is provided. The method for treating and/or alleviating nervous diseases includes: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.