公开(公告)号：US20210290710A1

公开(公告)日：2021-09-23

申请号：US17138610

申请日：2020-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Kuei-Chang LI ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Yen-Wu HSIEH ,  Shu-Fang WEN

IPC: A61K36/074 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61K31/575 ,  A61P25/28 ,  A61P25/20 ,  A61P1/00

Abstract: A composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US20190192597A1

公开(公告)日：2019-06-27

申请号：US15852748

申请日：2017-12-22

Applicant: Industrial Technology Research Institute

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Po-Yao HSU ,  Ming-Han LI ,  Kai-An CHUANG ,  Chih-Hsuan CHANG

IPC: A61K36/287 ,  A61K9/00 ,  A61P17/06 ,  A61P17/04

CPC classification number: A61K36/287 ,  A61K9/0014 ,  A61K2236/19 ,  A61K2236/51 ,  A61K2236/53 ,  A61P17/04 ,  A61P17/06

Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

公开(公告)号：US20240165181A1

公开(公告)日：2024-05-23

申请号：US18327583

申请日：2023-06-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Kuei-Chang LI ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Yen-Wu HSIEH ,  Shu-Fang WEN

IPC: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

CPC classification number: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US20220339137A1

公开(公告)日：2022-10-27

申请号：US17860952

申请日：2022-07-08

Applicant: Industrial Technology Research Institute

Inventor： I-Hong PAN ,  Ming-Han LI ,  Kai-An CHUANG ,  Shu-Fang WEN

IPC: A61K31/353 ,  A61K9/00 ,  A61P17/06 ,  A61P29/00 ,  A61K9/06

Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.

公开(公告)号：US20190183949A1

公开(公告)日：2019-06-20

申请号：US15845394

申请日：2017-12-18

Applicant: Industrial Technology Research Institute

Inventor： I-Hong PAN ,  Wei-Hsuan HSU ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Hsin-Chieh WU

IPC: A61K36/04 ,  A61P25/24 ,  A61P25/28 ,  A61P25/22

CPC classification number: A61K36/04 ,  A61K8/97 ,  A61K35/00 ,  A61K2236/00 ,  A61K2236/19 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

Abstract: The present disclosure provides a method for treating and/or alleviating nervous diseases, including: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.

公开(公告)号：US20190000776A1

公开(公告)日：2019-01-03

申请号：US16023940

申请日：2018-06-29

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW

IPC: A61K31/047 ,  A61K31/222 ,  A61K31/075 ,  A61K31/122 ,  A61K31/343 ,  A61K9/14 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40 ,  A61P25/28 ,  A61P37/00

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, —SO2CH3, —(C═O)—CH3 or —(C═O)—NH2.

公开(公告)号：US20220249395A1

公开(公告)日：2022-08-11

申请号：US17727301

申请日：2022-04-22

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  Shu-Fang WEN ,  Meng-Nan LIN ,  I-Huang LU ,  Zong-Keng KUO ,  Chu-Hsun LU ,  Tze-Chung LEE ,  Ya-Yan YANG ,  Jia-Horng LIAW ,  Pei-Hsin LIN

IPC: A61K31/047 ,  A61K31/215 ,  A61K31/335 ,  A61K9/50 ,  A61K31/352 ,  A61K9/00 ,  A61K31/045 ,  A61P37/00 ,  A61P25/28 ,  A61K9/08 ,  A61K9/14 ,  A61K31/075 ,  A61K31/122 ,  A61K31/222 ,  A61K31/343 ,  A61K47/02 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40

Abstract: A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, Z is O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO2, —NH2, —NR3R4, carbonyl, alkoxyl, alkyl or —OCF3, wherein R3 and R4 independently are H, alkyl, O2CH3, —(C═O)—CH3 or (C═O)—NH2.

公开(公告)号：US20210015882A1

公开(公告)日：2021-01-21

申请号：US17036985

申请日：2020-09-29

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei HUANG ,  I-Horng PAN ,  Ying-Fei TSAI ,  I-Huang LU ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Zong-Keng KUO ,  Shu-Jiau CHIOU

IPC: A61K36/75 ,  A61K31/395 ,  A61K31/366 ,  A61K31/37 ,  A61K31/4015 ,  A61K31/404

Abstract: The present disclosure provides a pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis, including: an effective amount of an extract of a plant belonging to Rutaceae as an effective ingredient for treating or alleviating the autoimmune disease and/or complication thereof and/or nephritis, wherein the autoimmune disease is selected from a group consisting of lupus erythematosus, psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis, juvenile idiopathic arthritis, Crohn's disease and ulcerative colitis (UC).

公开(公告)号：US20240216454A1

公开(公告)日：2024-07-04

申请号：US18396942

申请日：2023-12-27

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei HUANG ,  I-Hong PAN ,  I-Huang LU ,  Shu-Fang WEN

IPC: A61K36/28 ,  A61P17/00

CPC classification number: A61K36/28 ,  A61P17/00 ,  A61K2236/331 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/53

Abstract: A method for treating dermatitis is provided. The method for treating dermatitis includes administering an effective amount of an Adenostemma lavenia extract or administering an effective amount of a pharmaceutical composition for treating dermatitis including an Adenostemma lavenia extract to a subject in need thereof, wherein the dermatitis comprises atopic dermatitis or contact dermatitis.

公开(公告)号：US20210322496A1

公开(公告)日：2021-10-21

申请号：US17365207

申请日：2021-07-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong PAN ,  Wei-Hsuan HSU ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Hsin-Chieh WU

IPC: A61K36/04 ,  A61K35/744 ,  A61K8/9789 ,  A61Q19/08 ,  A61K35/747 ,  A23L33/105 ,  A23L33/00 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24

Abstract: A method for treating and/or alleviating nervous diseases is provided. The method for treating and/or alleviating nervous diseases includes: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.