公开(公告)号：US20220242921A1

公开(公告)日：2022-08-04

申请号：US17588736

申请日：2022-01-31

Applicant: INDUSTRY ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY

Inventor： Yoon Kyung PARK ,  Hee Kyoung KANG

IPC: C07K14/315 ,  A61P31/04 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/10 ,  A23L33/18 ,  A23K20/147

Abstract: A peptide according to an embodiment of the present in which, in the amino acid sequence of SEQ ID NO: 1, (i) 2nd and 4th amino acids are each substituted with tryptophan (W); (ii) 2nd, 4th, 11st and 13rd amino acids are each substituted with tryptophan; and (iii) 2nd, 4th, 19th, 20th, 22nd, 23rd, 26th and 27th amino acids are each substituted with tryptophan. The peptide can be usefully applied as an active ingredient for antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides and quasi-drugs.

公开(公告)号：US20230303638A1

公开(公告)日：2023-09-28

申请号：US18210179

申请日：2023-06-15

Applicant: INDUSTRY ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY

Inventor： Yoon Kyung PARK ,  Hee Kyoung KANG

IPC: C07K14/315 ,  A61P31/04 ,  A61K8/64 ,  A61Q19/00 ,  A23L33/18 ,  A23K20/147 ,  A61Q19/10

CPC classification number: C07K14/3156 ,  A61P31/04 ,  A61K8/64 ,  A61Q19/007 ,  A23L33/18 ,  A23K20/147 ,  A61Q19/10 ,  A23V2002/00 ,  A61K38/00

Abstract: In a method of killing or reducing a growth of methicillin-resistant Staphylococcus aureus (S. aureus), a composition including a peptide consisting of the amino acid sequence of SEQ ID NO:2 or 3 is administered to a subject in need thereof. The peptide can be usefully applied as an active ingredient for antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides and quasi-drugs.

公开(公告)号：US20150297673A1

公开(公告)日：2015-10-22

申请号：US14789041

申请日：2015-07-01

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Yoon Kyung PARK ,  Jong Kuk LEE

IPC: A61K38/10 ,  C07K7/08

CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K14/205 ,  Y02A50/473

Abstract: The present invention relates to a novel antibiotic peptide originated from the ribosomal protein L1 of Helicobacter pylori and a use of the same. Particularly, the novel peptide represented by SEQ. ID. NO: 4 was synthesized by replacing phenylalanine, the 12th amino acid of the peptide composed of the amino acid sequence represented by SEQ. ID. NO: 3, with proline. The present inventors confirmed that the novel peptide had a significant antibacterial activity but had no cytotoxicity. In addition, the inventors confirmed that the peptide of the invention had in vivo anti-inflammatory effect, so that the novel peptide can be used as an active ingredient of a natural antibacterial agent.

Abstract translation: 本发明涉及一种起源于幽门螺杆菌的核糖体蛋白L1的新型抗生素肽及其应用。 特别地，SEQ ID NO： ID。 通过将由SEQ ID NO：1表示的氨基酸序列构成的肽的第12位氨基酸替代为苯丙氨酸来合成NO：4。 ID。 NO：3，用脯氨酸。 本发明人证实，该新型肽具有显着的抗菌活性，但没有细胞毒性。 此外，本发明人确认本发明的肽具有体内抗炎作用，因此可以将新型肽用作天然抗菌剂的有效成分。