公开(公告)号：US20190054180A1

公开(公告)日：2019-02-21

申请号：US16179876

申请日：2018-11-02

申请人： INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS

发明人： Yong-Hee KIM ,  Tae-Hwan KIM ,  Chul-Su YANG ,  Yoonsung SONG ,  Jee-Young CHUNG ,  Sungsin JO ,  So Mi KIM ,  Qurrat Ul AIN ,  Ye-Ram KIM

IPC分类号： A61K47/62 ,  C12N15/113 ,  A61K31/7088 ,  A61P37/06 ,  A61P19/02

CPC分类号： A61K47/62 ,  A61K31/7088 ,  A61K47/6455 ,  A61P19/02 ,  A61P37/06 ,  C12N15/1137 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/3517 ,  C12N2310/531 ,  C12N2320/32 ,  C12Y304/24086

摘要： Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-α converting enzyme (TNF-α converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).

公开(公告)号：US20180193474A1

公开(公告)日：2018-07-12

申请号：US15721199

申请日：2017-09-29

申请人： INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS

发明人： Yong-Hee KIM ,  Chul-Su YANG ,  Yoonsung SONG ,  So Mi KIM ,  Ye-Ram KIM ,  Jee-Young CHUNG ,  Qurrat UI AIN

IPC分类号： A61K47/64 ,  A61K31/7105 ,  A61K48/00 ,  A61P37/06 ,  A61K47/56 ,  A61K47/18 ,  A61K31/738

CPC分类号： A61K47/6455 ,  A61K31/7105 ,  A61K31/738 ,  A61K47/183 ,  A61K47/56 ,  A61K48/0041 ,  A61K48/0066 ,  A61P37/06

摘要： Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-α converting enzyme (TNF-α converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).