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    ADIPOCYTE-TARGETING NON-VIRAL GENE DELIVERY COMPLEX COMPRISING DUAL PLASMID VECTOR
    5.
    发明申请
    ADIPOCYTE-TARGETING NON-VIRAL GENE DELIVERY COMPLEX COMPRISING DUAL PLASMID VECTOR 审中-公开

    公开(公告)号：US20190307898A1

    公开(公告)日：2019-10-10

    申请号：US16315346

    申请日：2017-06-30

    申请人： Industry-University Cooperation Foundation Hanyang University

    发明人： Yong-Hee KIM ,  Hyung Jin KIM

    IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/85 ,  A61P3/04

    摘要： The present disclosure relates to: an adipocyte-targeting non-viral gene delivery complex comprising a sh(FABP4+FABP5) dual plasmid vector; and treatment for obesity and obesity-induced metabolic syndromes by using the same and, more particularly, to a gene delivery complex comprising: an adipocyte-targeting sequence; a nine-arginine (R9) peptide; and a dual plasmid vector comprising a gene for treatment of obesity and obesity-induced metabolic syndromes, wherein the gene for treatment of obesity and obesity-induced metabolic syndromes is a base sequence inhibiting the expression of a FABP4 gene and a FABP5 gene. According to the present disclosure, in order to treat obesity-related diseases, a dual plasmid vector capable of simultaneously inhibiting the FABP4 and FABP5 genes is produced, and this vector is bound to a predetermined delivery system that specifically delivers the vector into adipocytes so as to provide a gene delivery complex. In this way, it is possible to achieve an excellent therapeutic effect on obesity which targets only adipocytes without cytotoxicity.

    DUAL-TARGETING LIPID-POLYMER HYBRID NANOPARTICLES
    7.
    发明申请
    DUAL-TARGETING LIPID-POLYMER HYBRID NANOPARTICLES 有权

    公开(公告)号：US20210379197A1

    公开(公告)日：2021-12-09

    申请号：US17228224

    申请日：2021-04-12

    申请人： IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

    发明人： Yong-Hee KIM ,  Seok-Beom YONG ,  Jee Young CHUNG ,  Seong Su KIM ,  Jae Hyun KIM ,  Se Hee RA

    IPC分类号： A61K47/68 ,  A61K9/51 ,  A61K45/06 ,  A61K33/30 ,  A61K33/26 ,  A61K33/32 ,  A61K33/24 ,  A61K47/54 ,  A61K47/69 ,  A61P35/02

    摘要： The present invention relates to dual-targeting lipid-polymer hybrid nanoparticles (T-hNPs) comprising a polymer core comprising a heme oxygenase 1 inhibitor and a lipid membrane (shell) comprising a targeting moiety, a kit for preparing the dual-targeting lipid-polymer hybrid nanoparticles, a pharmaceutical composition comprising the dual-targeting lipid-polymer hybrid nanoparticles as an active ingredient, and a method of preventing or treating cancer comprising administering the pharmaceutical composition to a subject in need thereof. Accordingly, the present invention can provide the dual-targeting lipid-polymer hybrid nanoparticles (T-hNPs) comprising a polymer core comprising a heme oxygenase 1 inhibitor and a lipid membrane (shell) comprising a targeting moiety, the kit for preparing the dual-targeting lipid-polymer hybrid nanoparticles (T-hNPs), the pharmaceutical composition comprising the dual-targeting lipid-polymer hybrid nanoparticles (T-hNPs) as an active ingredient, and the method of preventing or treating cancer comprising administering the pharmaceutical composition to a subject in need thereof.