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1.发明公开公开(公告)号：US20240117344A1
公开(公告)日：2024-04-11
申请号：US18305809
申请日：2023-04-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , Fondation Imagine , UNIVERSITE PARIS CITE , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3521 , C12N2320/33
摘要： The present invention relates to methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof. In particular, the present invention relates to a method for performing antisense oligonucleotide-mediated exon skipping in a retina cell of a subject comprising the step of injecting into the vitreous of the subject an amount of the antisense oligonucleotide.
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公开(公告)号：US20230235326A1
公开(公告)日：2023-07-27
申请号：US18000538
申请日：2021-06-04
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PARIS CITÉ , FONDATION IMAGINE , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
IPC分类号： C12N15/113 , C07K16/18 , C12N15/115 , A61P27/02
CPC分类号： C12N15/113 , C07K16/18 , C12N15/115 , A61P27/02 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2310/11 , C12N2310/13 , C12N2310/12
摘要： The present invention relates to a method for treating ocular disease in a subject in need thereof comprising a step of administering to said subject a therapeutically amount of an inhibitor of SOX21 gene expression and/or activity. By studying a mouse model of congenital microcoria, the inventors demonstrate that this ultra-rare and purely ocular disease is due to unanticipated complex mechanisms linked with 3D regulation of gene expression. They propose that the disease is due to the illegitimate expression of a transcription factor, SOX21, induced by the adoption of a DCT enhancer(s). They show that SOX21 binds to a regulatory region of the Tgfβ2 gene and the inventors demonstrate overexpression of this trophic factor in the iris and accumulation of its product in the aqueous humor of the mouse carrying the minimal MCOR deletion which recapitulates the observed accumulation in patients with POAG and one of our patient with MCOR.
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3.发明申请公开(公告)号：US20190037583A2
公开(公告)日：2019-01-31
申请号：US14903477
申请日：2014-07-08
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , FONDATION IMAGINE , UNIVERSITE PARIS DESCARTES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
摘要： The present invention relates to methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof. In particular, the present invention relates to a method for performing antisense oligonucleotide-mediated exon skipping in a retina cell of a subject comprising the step of injecting into the vitreous of the subject an amount of the antisense oligonucleotide.
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4.发明申请METHODS FOR PERFORMING ANTISENSE OLIGONUCLEOTIDE-MEDIATED EXON SKIPPING IN THE RETINA OF A SUBJECT IN NEED THEREOF 审中-公开用于在需要的受试者的后遗症中进行抗原寡核苷酸介导的外显子的方法公开(公告)号：US20160150555A1
公开(公告)日：2016-05-26
申请号：US14903477
申请日：2014-11-07
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , FOUNDATION IMAGINE , UNIVERSITE PARIS DESCARTES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
CPC分类号： H04W72/1231 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3521 , C12N2320/33 , H04L1/00 , H04L1/1841 , H04L1/1874 , H04L5/006 , H04L5/0064 , H04L43/0882 , H04L47/823 , H04W24/00 , H04W28/0205 , H04W28/0231 , H04W28/0236 , H04W28/0278 , H04W72/1252
摘要： A method, an apparatus, and a computer program product for wireless communication are provided. The apparatus determines an observed bit rate based on uplink transmissions of the UE, estimates an available link capacity for the UE, selects an estimate factor, and estimates available uplink throughput for future uplink transmissions of the UE as a function of the observed bit rate, the estimated available link capacity, and the estimate factor.
摘要翻译： 提供了一种用于无线通信的方法，装置和计算机程序产品。 该设备基于UE的上行链路传输确定观察到的比特率，估计UE的可用链路容量，选择估计因子，并且估计用于UE的未来上行链路传输的可用上行链路吞吐量作为观察到的比特率的函数， 估计可用链路容量和估计因子。
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