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公开(公告)号：US20180251731A1
公开(公告)日：2018-09-06
申请号：US15758139
申请日：2016-09-06
申请人： INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
IPC分类号： C12N5/0783 , G01N33/50
CPC分类号： C12N5/0637 , C12N2501/2302 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2501/727 , C12N2501/999 , G01N33/505 , G01N2800/245 , G01N2800/60
摘要： Disclosed is a new subpopulation of CD8+CD45RClow Tregs, namely IFNγ+IL-10+IL-34+ secreting population of CD8+CD45RClow Treg cells, methods for their isolation and expansion and their use as drug, more particularly for immunotherapy as well as biomarker
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公开(公告)号：US20220033500A1
公开(公告)日：2022-02-03
申请号：US17277511
申请日：2019-09-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
发明人： Carole GUILLONNEAU , Ignacio ANEGON
摘要： Isolated anti-human CD45RC antibodies or binding fragments thereof, nucleic acids and expression vector encoding the same, compositions including the same, and uses thereof as medicaments, including for the prevention and/or treatment of CD45RChigh-related diseases (including autoimmune diseases, undesired immune responses, monogenic diseases, and lymphoma or cancer), in particular for use in preventing and/or treating graft-versus-host disease (GVHD).
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公开(公告)号：US20210163593A1
公开(公告)日：2021-06-03
申请号：US16772917
申请日：2018-12-14
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES , UNIVERSITÉ DE NANTES
发明人： Carole GUILLONNEAU , Ignacio ANEGON
摘要： Anti-CD45RC antibodies, for use in the treatment of monogenic diseases caused by genes not associated with immune function but whose deficiency is associated with inflammation and/or immune reactions (such as genes deficient in Duchenne muscular dystrophy (DMD), cystic fibrosis, lysosomal diseases and al-anti-trypsin deficiency); or caused by genes involved in the immune system and whose deficiency generates inflammation and/or autoimmune reactions (such as genes deficient in T-cell primary immunodeficiencies such as IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome), APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy), B cell primary immunodeficiencies, Muckle-Wells syndrome, mixed autoinflammatory and autoimmune syndrome, NLRP12-associated hereditary periodic fever syndrome, and tumor necrosis factor receptor 1 associated periodic syndrome).
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公开(公告)号：US20180106779A1
公开(公告)日：2018-04-19
申请号：US15573068
申请日：2016-05-12
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
IPC分类号： G01N33/50 , G01N33/68 , C12N5/0783
摘要： Disclosed is a method for labeling, detecting and/or isolating Foxp3+ Treg cells from a biological sample containing peripheral blood mononuclear cells (PBMC) or lymphocytes including the following steps of: (i) coupling the surface of PBMC or lymphocytes to a capture moiety which binds to the cell through a cell surface molecule and to interleukin-34 (IL34), (ii) culturing the lymphocytes under conditions wherein IL34 is secreted, released and specifically captured by the capture moiety, (iii) labeling the IL34 expressing lymphocytes with a label moiety, and (iv) optionally detecting and/or isolating the IL34 expressing lymphocytes which are Foxp3+ Treg cells. Also disclosed is an isolated population of Foxp3+ Treg cells obtainable by the method and uses thereof.
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公开(公告)号：US20200308543A1
公开(公告)日：2020-10-01
申请号：US16899142
申请日：2020-06-11
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
IPC分类号： C12N5/0783 , C12N5/0786 , A61P37/06 , A61K35/15 , A61K35/17
摘要： Disclosed is a method for obtaining a population of human Treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (IL-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (PBMCs) and the population of immunosuppressive macrophages obtained at step (a).
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公开(公告)号：US20180187151A1
公开(公告)日：2018-07-05
申请号：US15740997
申请日：2016-07-01
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
IPC分类号： C12N5/0783 , C12N5/0786 , A61K35/17 , A61K35/15 , A61P37/06
摘要： Disclosed is a method for obtaining a population of human Treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (IL-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (PBMCs) and the population of immunosuppressive macrophages obtained at step (a).
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公开(公告)号：US20170226209A1
公开(公告)日：2017-08-10
申请号：US15500615
申请日：2015-07-31
发明人： Carole GUILLONNEAU , Ignacio ANEGON
IPC分类号： C07K16/28 , A61K38/13 , A61K31/436 , A61K31/664 , A61K39/395 , A61K45/06
CPC分类号： C07K16/289 , A61K31/436 , A61K31/664 , A61K38/13 , A61K39/3955 , A61K45/06 , A61K2039/507 , A61K2039/577
摘要： The invention relates to an isolated anti-CD45RC antibody for use in preventing or treating transplant rejection, autoimmune diseases, unwanted immune responses against proteins expressed in the course of gene therapy and/or therapeutic proteins, allergy as well as lymphoma or cancer which are associated with CD45RC+ cells. The invention relates to an isolated anti-CD45RC antibody for use in expanding and/or potentiating regulatory T cells.
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公开(公告)号：US20220098264A1
公开(公告)日：2022-03-31
申请号：US17422556
申请日：2020-01-15
IPC分类号： C07K14/54 , C12N5/0786
摘要： Interleukin-34 is a cytokine that is involved in the differentiation and survival of macrophages, monocytes, and dendritic cells in response to inflammation. The involvement of IL-34 has been shown in areas as diverse as neuronal protection, autoimmune diseases, infection, cancer, and transplantation. Recent work has also demonstrated a new and possible therapeutic role for IL-34 as a Foxp3+ Treg-secreted cytokine mediator of transplant tolerance. New mutated IL-34 polypeptides have been generated, which can be used as agonists or antagonists.
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公开(公告)号：US20210147801A1
公开(公告)日：2021-05-20
申请号：US16630098
申请日：2018-07-12
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES , CENTRE HOSPITALER UNIVERSITAIRE DE NANTES
IPC分类号： C12N5/0783 , A61K35/17 , A61P37/06
摘要： A population of highly suppressive human CD8+CD45RClow/− Tregs is characterized by expressing Foxp3 and producing IFNγ, IL-10, IL-34 and TGFβ to mediate their suppressive activity. Accordingly, methods capable of increasing expansion and immunosuppressive capacity of such a population of CD8+CD45RClow/− Tregs are highly desirable for therapeutic purposes. Rapamycin has been shown to increase the expansion and immunosuppressive capacities of the population of CD8+CD45RClow/− Tregs. Accordingly, the method of increasing expansion and immunosuppressive capacity of a population of CD8+CD45RClow/− Tregs includes culturing the population of CD8+CD45RClow/− Tregs in presence of a rapamycin compound.
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公开(公告)号：US20180015101A1
公开(公告)日：2018-01-18
申请号：US15521950
申请日：2015-10-27
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES , ONIRIS
发明人： Ignacio ANEGON , Philippe BLANCOU , Thomas SIMON , Julien POGU
IPC分类号： A61K31/555 , A61K39/04 , C12N5/078 , A61K39/00
CPC分类号： A61K31/555 , A61K31/409 , A61K39/0008 , A61K39/001 , A61K39/04 , A61K45/06 , A61K2039/5154 , A61K2039/54 , A61K2039/55511 , A61K2039/577 , A61K2039/58 , C12N5/0634 , C12N2501/71 , A61K2300/00
摘要： The invention is in the field of immunotherapy. More particularly, the invention provides a composition comprising a Heme Oxygenase-1 (HO-1) and antigens. Also provided herein are methods of administering the compositions of the invention by subcutaneous, intradermal or topical administration in a patient for inducing antigen-specific tolerance.
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