公开(公告)号：US20160376557A1

公开(公告)日：2016-12-29

申请号：US15125596

申请日：2015-03-19

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Universite Paris - SUD ,  Université de Rennes ,  Université Paris Descartes

发明人： Anne DUBART KUPPERSCHMITT ,  Anne WEBER BENAROUS ,  Anne CORLU ,  Noushin DIANAT

IPC分类号： C12N5/071 ,  A61K35/407

CPC分类号： C12N5/0679 ,  A61K35/407 ,  C12N5/0672 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/02 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/12 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/2306 ,  C12N2501/305 ,  C12N2501/385 ,  C12N2501/395 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/14 ,  C12N2506/45 ,  C12N2533/54

摘要： The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.

摘要翻译： 本发明涉及诱导称为成肝细胞的祖细胞的人胆管细胞分化的方法。 更具体地，本发明涉及通过用具有白细胞介素-6（IL-6）活性的特定培养基培养所述成肝细胞来将成肝细胞与胆管细胞分化的方法。 分化方法可以特异性诱导来自成肝细胞的胆管细胞分化，根据本发明分化的人胆管细胞可用于治疗胆管病和生物工程化肝的药物发现。

公开(公告)号：US20210324338A1

公开(公告)日：2021-10-21

申请号：US17325693

申请日：2021-05-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE PARIS - SUD ,  UNIVERSITÉ DE RENNES

发明人： Anne DUBART KUPPERSCHMITT ,  Anne WEBER BENAROUS ,  Anne CORLU ,  Noushin DIANAT

IPC分类号： C12N5/071 ,  A61K35/407

摘要： The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte dilferentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.