公开(公告)号：US20250145632A1

公开(公告)日：2025-05-08

申请号：US18721125

申请日：2022-12-21

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Hongfu LU ,  Jingjing PENG ,  Xiao DING ,  Jinxin LIU ,  Yingtao LIU ,  Feng REN ,  Fusheng ZHOU ,  Tao JIANG ,  Tao LIANG ,  Jiong LAN ,  Qiang LU

IPC: C07D487/22 ,  A61K31/519 ,  A61K31/675 ,  A61P35/00 ,  C07D471/22 ,  C07D487/16 ,  C07D498/16 ,  C07D498/22 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention discloses a pyrimidine heterocyclic compound, and a preparation method and medical use thereof. Specifically, the present invention discloses a pyrimidine heterocyclic compound with a structure shown in Formula (A) or a pharmaceutically acceptable salt thereof (groups are each defined in the specification), a pharmaceutical composition comprising the compound, and use of the compound in treatment of cell proliferative diseases (such as cancers).