公开(公告)号：US20250145632A1

公开(公告)日：2025-05-08

申请号：US18721125

申请日：2022-12-21

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Hongfu LU ,  Jingjing PENG ,  Xiao DING ,  Jinxin LIU ,  Yingtao LIU ,  Feng REN ,  Fusheng ZHOU ,  Tao JIANG ,  Tao LIANG ,  Jiong LAN ,  Qiang LU

IPC: C07D487/22 ,  A61K31/519 ,  A61K31/675 ,  A61P35/00 ,  C07D471/22 ,  C07D487/16 ,  C07D498/16 ,  C07D498/22 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention discloses a pyrimidine heterocyclic compound, and a preparation method and medical use thereof. Specifically, the present invention discloses a pyrimidine heterocyclic compound with a structure shown in Formula (A) or a pharmaceutically acceptable salt thereof (groups are each defined in the specification), a pharmaceutical composition comprising the compound, and use of the compound in treatment of cell proliferative diseases (such as cancers).

公开(公告)号：US20230192624A1

公开(公告)日：2023-06-22

申请号：US18107127

申请日：2023-02-08

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Jingjing PENG ,  Feng REN ,  Xiaoyu DING ,  Bogdan ZAGRIBELNYY ,  Yan A. IVANENKOV

IPC: C07D233/96 ,  A61P31/14

CPC classification number: C07D233/96 ,  A61P31/14

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.

公开(公告)号：US20240025860A1

公开(公告)日：2024-01-25

申请号：US18339366

申请日：2023-06-22

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Jingjing PENG ,  Feng REN ,  Xiaoyu DING ,  Bogdan ZAGRIBELNYY ,  Yan A. IVANENKOV

IPC: C07D233/96 ,  A61P31/14

CPC classification number: C07D233/96 ,  A61P31/14

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.