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公开(公告)号：US20240166608A1
公开(公告)日：2024-05-23
申请号：US18529689
申请日：2023-12-05
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Jinxin LIU , Feng REN , Jianfei WAN , Wei ZHU
IPC: C07D231/56 , A61P35/00 , C07D209/44 , C07D215/14 , C07D401/04 , C07D403/08 , C07D471/04 , C07D487/04
CPC classification number: C07D231/56 , A61P35/00 , C07D209/44 , C07D215/14 , C07D401/04 , C07D403/08 , C07D471/04 , C07D487/04
Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.
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公开(公告)号：US20230192723A1
公开(公告)日：2023-06-22
申请号：US18110261
申请日：2023-02-15
Applicant: Insilico Medicine IP Limited
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.
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公开(公告)号：US20230192688A1
公开(公告)日：2023-06-22
申请号：US18110259
申请日：2023-02-15
Applicant: Insilico Medicine IP Limited
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.
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公开(公告)号：US20250145624A1
公开(公告)日：2025-05-08
申请号：US18837843
申请日：2023-02-17
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Fanye MENG , Feng REN , Yazhou WANG , Min ZHENG
IPC: C07D471/16 , A61K31/55 , C07D487/16
Abstract: Described herein are PKMYT1 (Myt1) inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with PKMYT1.
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公开(公告)号：US20250136596A1
公开(公告)日：2025-05-01
申请号：US18837846
申请日：2023-02-17
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Yangguang LI , Yingtao LIU , Fanye MENG , Feng REN , Yazhou WANG , Min ZHENG
IPC: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/53 , A61K31/541 , C07D487/04 , C07D519/00
Abstract: Described herein are PKMYT1 (Myt1) inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with PKMYT1.
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Patent Agency Ranking
公开(公告)号：US20240150374A1
公开(公告)日：2024-05-09
申请号：US18507566
申请日：2023-11-13
Applicant: Insilico Medicine IP Limited
Inventor： Xin CHENG , Luoheng QIN , Feng REN
IPC: C07D498/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D498/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.
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公开(公告)号：US20240002406A1
公开(公告)日：2024-01-04
申请号：US18339362
申请日：2023-06-22
Applicant: Insilico Medicine IP Limited
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.
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公开(公告)号：US20230192667A1
公开(公告)日：2023-06-22
申请号：US18110517
申请日：2023-02-16
Applicant: Insilico Medicine IP Limited
Inventor： Xin CHENG , Yingtao LIU , Luoheng QIN , Feng REN , Jianping WU
IPC: C07D403/14 , C07D403/04 , C07D417/14 , C07D401/14 , C07D405/14 , C07D413/14 , A61P35/00
CPC classification number: C07D403/14 , A61P35/00 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.
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公开(公告)号：US20240067661A1
公开(公告)日：2024-02-29
申请号：US18240886
申请日：2023-08-31
Applicant: Insilico Medicine IP Limited
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.
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公开(公告)号：US20250163077A1
公开(公告)日：2025-05-22
申请号：US18837847
申请日：2023-02-17
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Feng REN , Yazhou WANG , Min ZHENG
IPC: C07D519/00 , A61K31/437 , A61K31/4985 , A61K31/519
Abstract: Described herein are PKMYT1 (Myt1) inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with PKMYT1.
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