公开(公告)号：US11717543B2

公开(公告)日：2023-08-08

申请号：US16907381

申请日：2020-06-22

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) ,  ECOLE D'INGENIEURS DE PURPAN

发明人： Philippe Langella ,  Sylvie Miquel ,  Rebeca Martin Rosique ,  Luis Bermudez Humaran ,  Muriel Thomas ,  Harry Sokol ,  Frédéric Carvalho ,  Vassilia Theodorou

IPC分类号： A61K35/741 ,  A23L33/135 ,  A61P29/00

CPC分类号： A61K35/741 ,  A23L33/135 ,  A61P29/00

摘要： The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual.
The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.

公开(公告)号：US10918678B2

公开(公告)日：2021-02-16

申请号：US16072319

申请日：2017-01-23

申请人： Institut National De La Recherche Agronomique (INRA) ,  Sorbonne Universite ,  Assistance Publique—Hopitaux de Paris

发明人： Philippe Langella ,  Rebeca Martin Rosique ,  Luis Bermudez Humaran ,  Florian Chain ,  Harry Sokol

IPC分类号： A01N63/00 ,  A61K35/74 ,  A23L33/135 ,  C12R1/01 ,  A61K35/741 ,  A61P1/00

摘要： The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.

公开(公告)号：US20150139940A1

公开(公告)日：2015-05-21

申请号：US14402282

申请日：2013-05-15

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： Luis Bermudez Humaran ,  Philippe Langella ,  Pascale Kharrat

IPC分类号： C12N15/74 ,  A61K38/20 ,  C12N7/00 ,  A61K39/12

CPC分类号： C12N15/746 ,  A61K38/2066 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/523 ,  C12N7/00 ,  C12N2710/20034

摘要： The invention relates to prokaryotic expression cassettes comprising a stress-regulated promoter, the promoter of the GroESL operon of Lactococcus lactis. Said cassettes can be used for the expression of genes of interest in gram-positive bacteria, and especially for producing and releasing a protein of interest when the bacteria are administered to an individual.

摘要翻译： 本发明涉及包含应激调节启动子，乳酸乳球菌的GroESL操纵子的启动子的原核表达盒。 所述盒可以用于在革兰氏阳性细菌中表达感兴趣的基因，特别是当向个体施用细菌时，用于产生和释放感兴趣的蛋白质。