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公开(公告)号：US11717543B2
公开(公告)日：2023-08-08
申请号：US16907381
申请日：2020-06-22
申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) , ECOLE D'INGENIEURS DE PURPAN
发明人： Philippe Langella , Sylvie Miquel , Rebeca Martin Rosique , Luis Bermudez Humaran , Muriel Thomas , Harry Sokol , Frédéric Carvalho , Vassilia Theodorou
IPC分类号： A61K35/741 , A23L33/135 , A61P29/00
CPC分类号： A61K35/741 , A23L33/135 , A61P29/00
摘要： The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual.
The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.-
公开(公告)号：US10736927B2
公开(公告)日：2020-08-11
申请号：US15753475
申请日：2016-08-22
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
发明人： Harry Sokol , Mathias Lavie-Richard , Marie-Laure Michel , Bruno Michel Lamas , Philippe Langella
IPC分类号： A61K35/747 , C12R1/225 , A61P1/00 , G01N33/50
摘要： The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
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公开(公告)号：US09688742B2
公开(公告)日：2017-06-27
申请号：US14490161
申请日：2014-09-18
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , UNIVERSITE PARIS DIDEROT—PARIS 7
CPC分类号： C07K14/81 , A61K35/74 , C07K14/811 , C07K14/8121 , C07K14/8125 , C12N15/746
摘要： The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
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4.发明申请RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS) 有权用于预防和治疗炎症性腹膜疾病（IBD）和可疑牙刷综合征（IBS）的重组生物细菌公开(公告)号：US20150073125A1
公开(公告)日：2015-03-12
申请号：US14490161
申请日：2014-09-18
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , UNIVERSITE PARIS DIDEROT - PARIS 7
IPC分类号： C07K14/81
CPC分类号： C07K14/81 , A61K35/74 , C07K14/811 , C07K14/8121 , C07K14/8125 , C12N15/746
摘要： The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
摘要翻译： 本发明涉及炎症性肠病（IBD）和/或肠易激综合征（IBS）的一般治疗领域。 因此，本发明涉及选自转录蛋白-2蛋白或其活性部分的分子，WAP家族蛋白的成员或其活性部分或Serpin家族蛋白的成员或其活性部分，用于治疗 肠易激综合征（IBS）。 本发明还涉及一种重组食品级细菌，其包含选自编码trappin-2蛋白或其活性组分的基因的基因，编码WAP家族蛋白成员的基因或其活性组分，或 编码Serpin家族蛋白质成员的基因或其活性部分。
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公开(公告)号：US11013783B2
公开(公告)日：2021-05-25
申请号：US15802910
申请日：2017-11-03
发明人： Philippe Langella , Benedicte Pigneur-Arnaud , Jean-Marc Chatel , Elodie Quevrain , Philippe Seksik , Germain Trugnan , Florian Chain , Luis G Bermudez-Humaran , Marie-Anne Maubert , Christophe Michon , Harry Sokol
IPC分类号： A61K35/74 , A61K38/16 , A61K35/741
摘要： A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and Crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of SEQ ID NO: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a host cell that has been transfected, infected or transformed by said nucleic acid sequence and/or by said vector.
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公开(公告)号：US10918678B2
公开(公告)日：2021-02-16
申请号：US16072319
申请日：2017-01-23
申请人： Institut National De La Recherche Agronomique (INRA) , Sorbonne Universite , Assistance Publique—Hopitaux de Paris
发明人： Philippe Langella , Rebeca Martin Rosique , Luis Bermudez Humaran , Florian Chain , Harry Sokol
IPC分类号： A01N63/00 , A61K35/74 , A23L33/135 , C12R1/01 , A61K35/741 , A61P1/00
摘要： The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
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公开(公告)号：US20150139940A1
公开(公告)日：2015-05-21
申请号：US14402282
申请日：2013-05-15
CPC分类号： C12N15/746 , A61K38/2066 , A61K39/12 , A61K48/00 , A61K2039/523 , C12N7/00 , C12N2710/20034
摘要： The invention relates to prokaryotic expression cassettes comprising a stress-regulated promoter, the promoter of the GroESL operon of Lactococcus lactis. Said cassettes can be used for the expression of genes of interest in gram-positive bacteria, and especially for producing and releasing a protein of interest when the bacteria are administered to an individual.
摘要翻译： 本发明涉及包含应激调节启动子，乳酸乳球菌的GroESL操纵子的启动子的原核表达盒。 所述盒可以用于在革兰氏阳性细菌中表达感兴趣的基因，特别是当向个体施用细菌时，用于产生和释放感兴趣的蛋白质。
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公开(公告)号：US20130344033A1
公开(公告)日：2013-12-26
申请号：US13899179
申请日：2013-05-21
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , UNIVERSITE PARIS DIDEROT - PARIS 7 , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
IPC分类号： C12N15/74
CPC分类号： C07K14/81 , A61K35/74 , C07K14/811 , C07K14/8121 , C07K14/8125 , C12N15/746
摘要： The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
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