公开(公告)号：US20230145894A1

公开(公告)日：2023-05-11

申请号：US17996861

申请日：2021-04-26

Applicant: INSTITUT PASTEUR

Inventor： Thierry Rose ,  Sophie GOYARD ,  Laurent Lionel REBER ,  Yves JANIN

IPC: C07K16/42 ,  C12N9/02 ,  G01N33/535 ,  G01N33/533 ,  G01N33/577

CPC classification number: C07K16/4291 ,  C12N9/0069 ,  G01N33/535 ,  G01N33/533 ,  G01N33/577 ,  C07K2317/22 ,  C07K2317/622

Abstract: The present invention relates to a fusion protein comprising: —a N-terminal domain which comprises an antibody which is a variable domain of a camelid heavy-chain antibody (VHH) or a single chain variable fragment (scFV) and which is directed against an immunoglobulin and —a C-terminal domain which comprises a polypeptide with a luciferase activity: —having the amino acid sequence SEQ ID NO: 1 or —having at least 80% amino acid sequence identity to the amino acid sequence SEQ ID NO: 1.