公开(公告)号：US11365264B2

公开(公告)日：2022-06-21

申请号：US15105042

申请日：2014-12-22

Applicant: INSTITUT PASTEUR

Inventor： Jacques Theze ,  Thierry Rose ,  Florence Bugault

IPC: C07K16/40 ,  A61K39/38

Abstract: Methods for diagnosing or treating immune disorders in a subject are provided. The methods are based on the detection or modulation of Refractory state Inducing Factor (RIF).

公开(公告)号：US11938199B2

公开(公告)日：2024-03-26

申请号：US16607058

申请日：2018-04-30

Applicant: INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Yves-Louis Janin ,  Eloi Paul Coutant ,  Vincent Hervin ,  Glwadys Gagnot ,  Yves Jacob ,  Sophie Goyard ,  Thierry Rose

IPC: A61K49/00 ,  C07D487/04 ,  G01N21/76 ,  G01N33/573

CPC classification number: A61K49/0013 ,  C07D487/04 ,  G01N21/763 ,  G01N33/573

Abstract: The present invention is in the field of bioluminescence in biology and/or medicine. In particular, the invention provides imidazopyrazine derivatives, processes for preparation thereof, and their uses as luciferins.

公开(公告)号：US20230145894A1

公开(公告)日：2023-05-11

申请号：US17996861

申请日：2021-04-26

Applicant: INSTITUT PASTEUR

Inventor： Thierry Rose ,  Sophie GOYARD ,  Laurent Lionel REBER ,  Yves JANIN

IPC: C07K16/42 ,  C12N9/02 ,  G01N33/535 ,  G01N33/533 ,  G01N33/577

CPC classification number: C07K16/4291 ,  C12N9/0069 ,  G01N33/535 ,  G01N33/533 ,  G01N33/577 ,  C07K2317/22 ,  C07K2317/622

Abstract: The present invention relates to a fusion protein comprising: —a N-terminal domain which comprises an antibody which is a variable domain of a camelid heavy-chain antibody (VHH) or a single chain variable fragment (scFV) and which is directed against an immunoglobulin and —a C-terminal domain which comprises a polypeptide with a luciferase activity: —having the amino acid sequence SEQ ID NO: 1 or —having at least 80% amino acid sequence identity to the amino acid sequence SEQ ID NO: 1.