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公开(公告)号：US11324552B2
公开(公告)日：2022-05-10
申请号：US16511667
申请日：2019-07-15
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
IPC: A61B18/20 , A61K9/00 , A61Q19/00 , A61M37/00 , A61N5/06 , A61B90/00 , A61B17/00 , A61B18/00 , A61N5/067
Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.
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公开(公告)号：US20150025444A1
公开(公告)日：2015-01-22
申请号：US13945623
申请日：2013-07-18
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
CPC classification number: A61B18/201 , A61B18/20 , A61B18/203 , A61B2017/00765 , A61B2018/0047 , A61B2018/00577 , A61B2090/062 , A61B2090/3735 , A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N5/0613 , A61N2005/0627 , A61N2005/0632
Abstract: Methods and systems for laser assisted delivery of therapeutic agents include preparing a site with an ultraviolet laser beam, at a wavelength appropriate for tissue ablation, such that an opening is produced in a surface of the site's tissue; and applying one or more agents to the prepared site, such that the agents penetrate the tissue through the opening to a predetermined depth.
Abstract translation: 用于激光辅助递送治疗剂的方法和系统包括用适合于组织消融的波长制备具有紫外激光束的部位，使得在部位组织的表面产生开口; 以及将一种或多种试剂施用于制备的部位，使得试剂通过开口穿透组织至预定深度。
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公开(公告)号：US20190350653A1
公开(公告)日：2019-11-21
申请号：US16529065
申请日：2019-08-01
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
Abstract: A laser treatment system includes a laser device configured to produce a laser beam at a wavelength in an ultraviolet spectrum to provide for tissue ablation, a lens configured to focus and direct the laser beam to a site to form an opening in a surface of the site, a valve connected to a first channel, and a nozzle that emits the laser beam and controls delivery of at least a first substance and a second substance to the site. A portion of the first channel is disposed within a first sidewall of the nozzle to deliver the first substance, and a second channel unconnected with the valve is disposed within a second sidewall of the nozzle to deliver the second substance.
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公开(公告)号：US20190336212A1
公开(公告)日：2019-11-07
申请号：US16511667
申请日：2019-07-15
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.
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公开(公告)号：US12035966B2
公开(公告)日：2024-07-16
申请号：US16888693
申请日：2020-05-30
Applicant: International Business Machines Corporation
Inventor： James J. Wynne , Jerome M. Felsenstein , Robert S. Olyha, Jr.
CPC classification number: A61B18/20 , A61B5/0095 , G01N29/2418 , A61B2018/00452 , A61B2018/00577 , A61B2018/00642 , A61B2018/00904
Abstract: A method for controlled ablation of target tissue includes activating laser ablation of hyperkeratotic tissue upon detecting a trigger input signal, detecting a photo-acoustical signature due to the laser ablation of the hyperkeratotic tissue, detecting a change in the photo-acoustical signature due to the laser ablation of a material different than the hyperkeratotic tissue, and ceasing the laser ablation upon detecting, by a signal processor, the change in the photo-acoustical signature.
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Patent Agency Ranking
公开(公告)号：US20220241012A1
公开(公告)日：2022-08-04
申请号：US17718786
申请日：2022-04-12
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.
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7.发明申请公开(公告)号：US20150025445A1
公开(公告)日：2015-01-22
申请号：US13966974
申请日：2013-08-14
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
IPC: A61B18/20
Abstract: Systems for laser assisted delivery of therapeutic agents include an ultraviolet laser configured to produce a laser beam at a wavelength appropriate for tissue ablation; a lens configured to focus and direct the laser beam to a site, such that an opening is produced in a surface of the site's tissue; a nozzle having an aperture that emits the laser beam and that controls delivery of one or more agents to the site; and an imaging device configured to monitor a depth of penetration of the one or more agents into the site's tissue.
Abstract translation: 用于激光辅助递送治疗剂的系统包括被配置为产生适于组织消融的波长的激光束的紫外激光; 配置为将激光束聚焦并引导到位置的透镜，使得在所述部位的组织的表面中产生开口; 具有发射所述激光束并且控制一个或多个试剂到所述部位的输送的孔的喷嘴; 以及成像装置，被配置为监测所述一个或多个试剂穿入所述部位组织的深度。
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公开(公告)号：US12042222B2
公开(公告)日：2024-07-23
申请号：US17718786
申请日：2022-04-12
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
IPC: A61B18/20 , A61B17/00 , A61B18/00 , A61B90/00 , A61K9/00 , A61M37/00 , A61N5/06 , A61N5/067 , A61Q19/00
CPC classification number: A61B18/201 , A61B18/20 , A61B18/203 , A61K9/0012 , A61M37/0015 , A61N5/0613 , A61Q19/00 , A61B2017/00765 , A61B2018/0047 , A61B2018/00577 , A61B2018/20361 , A61B2018/205547 , A61B2090/062 , A61B2090/3735 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N2005/0626 , A61N2005/0627 , A61N2005/0632 , A61N2005/0661 , A61N2005/0662 , A61N5/067
Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.
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公开(公告)号：US11612433B2
公开(公告)日：2023-03-28
申请号：US16529065
申请日：2019-08-01
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
IPC: A61B18/20 , A61K9/00 , A61Q19/00 , A61M37/00 , A61N5/06 , A61B90/00 , A61B17/00 , A61B18/00 , A61N5/067
Abstract: A laser treatment system includes a laser device configured to produce a laser beam at a wavelength in an ultraviolet spectrum to provide for tissue ablation, a lens configured to focus and direct the laser beam to a site to form an opening in a surface of the site, a valve connected to a first channel, and a nozzle that emits the laser beam and controls delivery of at least a first substance and a second substance to the site. A portion of the first channel is disposed within a first sidewall of the nozzle to deliver the first substance, and a second channel unconnected with the valve is disposed within a second sidewall of the nozzle to deliver the second substance.
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公开(公告)号：US10456197B2
公开(公告)日：2019-10-29
申请号：US13966974
申请日：2013-08-14
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Jerome M. Felsenstein , James L. Hedrick , James J. Wynne , Donna S. Zupanski-Nielsen
Abstract: Systems for laser assisted delivery of therapeutic agents include an ultraviolet laser configured to produce a laser beam at a wavelength appropriate for tissue ablation; a lens configured to focus and direct the laser beam to a site, such that an opening is produced in a surface of the site's tissue; a nozzle having an aperture that emits the laser beam and that controls delivery of one or more agents to the site; and an imaging device configured to monitor a depth of penetration of the one or more agents into the site's tissue.
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