公开(公告)号：US11111496B2

公开(公告)日：2021-09-07

申请号：US16481799

申请日：2018-01-30

Applicant: INTREXON CORPORATION

Inventor： Xinhua Zhao ,  Mark Anton Held ,  Tina Huynh ,  Lily Yuin Chao ,  Na Trinh ,  Matthias Helmut Schmalisch ,  Bryan Yeh ,  James Kealey ,  Kevin Lee Dietzel

IPC: C12N15/52 ,  C12N1/20 ,  C12N9/00 ,  C12N9/88 ,  C12N15/74 ,  C12P5/02 ,  C12P7/16 ,  C12P7/18 ,  C12N9/04 ,  C12N9/10

Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US11198877B2

公开(公告)日：2021-12-14

申请号：US16481811

申请日：2018-01-30

Applicant: INTREXON CORPORATION

Inventor： Mark Anton Held ,  Xinhua Zhao ,  Lily Yuin Chao ,  Na Trinh ,  James Kealey ,  Kevin Lee Dietzel

IPC: C12N9/10 ,  C12N9/04 ,  C12N9/88 ,  C12P7/16 ,  C12P5/02 ,  C12N15/52 ,  C12N1/20 ,  C12N15/74 ,  C12P7/18

Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed. These microorganisms and methods make use of molecular switches to regulate gene expression.