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    Nanocells for diagnosis and treatment of diseases and disorders
    1.
    发明申请
    Nanocells for diagnosis and treatment of diseases and disorders 审中-公开
    用于诊断和治疗疾病和障碍的纳米细胞

    公开(公告)号：US20070065359A1

    公开(公告)日：2007-03-22

    申请号：US11375475

    申请日：2006-03-14

    申请人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos Bosques

    发明人： Shiladitya Sengupta ,  Ram Sasisekharan ,  Carlos Bosques

    IPC分类号： A61K51/00

    CPC分类号： A61K51/1241 ,  A61K9/1271 ,  A61K9/14 ,  A61K45/06 ,  A61K47/6923 ,  A61K47/6929 ,  A61K51/1244 ,  B82Y5/00 ,  B82Y10/00

    摘要： The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.

    摘要翻译： 本发明涉及新型纳米电池组合物及其在成像，诊断和治疗方法中的应用。 在一个实施方案中，针对成像方法定制的纳细胞包括由脂质基质包围的纳米孔，并且被修饰为含有放射性核素或具有发射光谱的纳米孔。 纳米细胞的尺寸受限于大于约60nm，使得它们在血管发生（例如肿瘤）的位置选择性地外渗，并且不通过正常的脉管系统或进入非肿瘤的组织。 以这种方式，可以检测和治疗血管生成位点。 在另一个实施方案中，针对各种治疗方法，包括治疗脑癌，哮喘，格雷夫氏病，囊性纤维化和肺纤维化，纳米细胞被定制。

    A REPORTER PLATFORM FOR REAL TIME MONITORING OF DRUG EFFICACY
    3.
    发明申请
    A REPORTER PLATFORM FOR REAL TIME MONITORING OF DRUG EFFICACY 审中-公开

    公开(公告)号：US20190070318A1

    公开(公告)日：2019-03-07

    申请号：US16079843

    申请日：2017-03-02

    申请人： Shiladitya SENGUPTA ,  Ashish KULKARNI ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

    发明人： Shiladitya SENGUPTA ,  Ashish KULKARNI

    IPC分类号： A61K49/00 ,  A61P35/00

    摘要： Described herein is a reporter material platform that can be used to directly monitor the drug response in real-time. The reporter material can include an activator element which undergoes a chemical change in response to an immunonological response to a drug, and the chemical change can be detected using a reporter element. The reporter material can include a drug and a reporter element that are physically constrained in a close proximity. The reporter element produces a signal only when the drug induces a direct or indirect physiological change in the tumor or surrounding tissue. The reporter material platform can self-assemble via supramolecular interactions. This reporter material platform can be used to directly monitor the drug response in real-time.

    METHODS AND COMPOSITIONS RELATED TO MODULATING THE EXTRACELLULAR STEM CELL ENVIRONMENT
    5.
    发明申请
    METHODS AND COMPOSITIONS RELATED TO MODULATING THE EXTRACELLULAR STEM CELL ENVIRONMENT 审中-公开
    与调节细胞外细胞环境相关的方法和组合物

    公开(公告)号：US20100119494A1

    公开(公告)日：2010-05-13

    申请号：US12689619

    申请日：2010-01-19

    申请人： SHILADITYA SENGUPTA ,  RAM SASISEKHARAN ,  NISHLA KEISER ,  DAVID EAVARONE ,  TANYEL KIZILTEPE BILGICER ,  AARTHI CHANDRASEKARAN ,  DAVID A. BERRY ,  KRISTINE HOLLEY

    发明人： SHILADITYA SENGUPTA ,  RAM SASISEKHARAN ,  NISHLA KEISER ,  DAVID EAVARONE ,  TANYEL KIZILTEPE BILGICER ,  AARTHI CHANDRASEKARAN ,  DAVID A. BERRY ,  KRISTINE HOLLEY

    IPC分类号： A61K35/12 ,  C12N5/02 ,  A61K31/715 ,  A61K38/43

    CPC分类号： A61K31/726 ,  A61K31/727 ,  A61K38/47 ,  C12N5/0606 ,  C12N5/0691 ,  C12N2501/70 ,  C12N2506/02

    摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Therefore, methods and compositions are provided for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.

    摘要翻译： 本发明部分涉及调节干细胞环境的方法和组合物。 更具体地，本发明部分涉及用于调节干细胞分化的方法和组合物。 因此，提供了在干细胞的微环境中调节糖胺聚糖部分（例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分）的方法和组合物。 还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。 因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如，内皮细胞群体或贫血的内皮细胞群体）。 此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。 此外，本发明还部分涉及使用提供的方法和组合物的治疗方法。