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公开(公告)号：US20170240933A1
公开(公告)日：2017-08-24
申请号：US15441343
申请日：2017-02-24
IPC分类号： C12P7/44 , C12P7/18 , C12P7/42 , C12N9/04 , C12N15/52 , C12N9/10 , C12N9/00 , C12N9/02 , C12N9/16 , C12P13/00 , C12N9/80
CPC分类号： C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
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2.发明申请Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis 有权通过与辅酶B合成相关的C1碳链伸长率生产7碳化合物的方法公开(公告)号：US20140193863A1
公开(公告)日：2014-07-10
申请号：US14138971
申请日：2013-12-23
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
摘要翻译： 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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3.发明申请Methods of Producing 7-Carbon Chemicals via CoA-Dependent Carbon Chain Elongation Associated with Carbon Storage 有权通过与碳储存相关的CoA依赖性碳链伸长率生产7碳化合物的方法公开(公告)号：US20140248673A1
公开(公告)日：2014-09-04
申请号：US14106033
申请日：2013-12-13
CPC分类号： C12P13/005 , C12N9/1029 , C12N9/93 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
摘要： This document describes biochemical pathways for producing pimelic acid, 7-hydroxyheptanoic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the CoA-dependent elongation enzymes or analog enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
摘要翻译： 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-羟基庚酸，7-氨基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于与聚羟基链烷酸酯累积细菌的碳储存途径相关的CoA依赖性延长酶或类似物酶。
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4.发明申请Methods Of Producing 7-Carbon Chemicals From Long Chain Fatty Acids Via Oxidative Cleavage 有权通过氧化裂解从长链脂肪酸生产7碳化合物的方法公开(公告)号：US20140193865A1
公开(公告)日：2014-07-10
申请号：US14139142
申请日：2013-12-23
CPC分类号： C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
摘要翻译： 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于脂肪酸合成途径以及通过单氧酶（例如细胞色素P450）如长链酰基 - [acp]中间体的氧化裂解，例如由BioI从微生物如枯草芽孢杆菌 。
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5.发明申请Methods Of Producing 7-Carbon Chemicals Via Carbon Chain Elongation Associated With Cyclohexane Carboxylate Synthesis 有权通过与环己烷羧酸酯合成相关的碳链伸长率生产7碳化合物的方法公开(公告)号：US20140193862A1
公开(公告)日：2014-07-10
申请号：US14138904
申请日：2013-12-23
CPC分类号： C12P13/001 , C12N9/0008 , C12N9/1096 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/002 , C12Y102/99006 , C12Y301/02002
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
摘要翻译： 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于与酸性营养不良食物或2-氨基己二酸赖氨酸生物合成的环己烷羧酸盐生物合成相关的碳链延长酶或其同系物。
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