公开(公告)号：US10555895B2

公开(公告)日：2020-02-11

申请号：US16330020

申请日：2017-09-06

Applicant: ISP Investments LLC ,  ELC Management LLC

Inventor： Nadine Pernodet ,  Dawn Layman ,  Jean-Marie Botto ,  Elodie Oger ,  Audrey Le Mestr ,  Isabelle Imbert ,  Nouha Domloge

IPC: A61K36/00 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q17/04 ,  A61K8/34 ,  A61K8/60 ,  A61K8/64

Abstract: The present invention provides a process for obtaining an extract from peach flower extract (Primus persica L.) for skin cosmetic use, a peach flower extract obtainable by the process and a cosmetic composition comprising the said extract. The invention further provides a method for modulating the SIRT2 expression, a method of treatment designed to reduce and/or correct the signs of aging and photo-aging of the skin and keratinous appendages, and to protect the skin against aggressions due to ultraviolet radiation.

公开(公告)号：US11248224B2

公开(公告)日：2022-02-15

申请号：US16612365

申请日：2018-04-27

Applicant: ISP Investments LLC

Inventor： Elodie Oger ,  Jean-Marie Botto

IPC: C12N5/10 ,  A61K8/9789 ,  C12N15/10 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q19/00

Abstract: The invention relates to a method for obtaining an aqueous extract of Anethum graveolens, enriched with small RNAs having a maximum length of 150 nucleotides, from a plant material, said method comprising the following steps: a) aerial parts of dill is brought into contact with water; b) tetrasodium ethylenediaminetetraacetic acid (EDTA) is added at a pH of between 10.5 and 11; c) the pH of the mixture obtained in b) is then adjusted to a value of between 6 and 8; d) the mixture obtained in c) is purified; and e) the pH is checked and readjusted if necessary to a value of between 6 and 8. The invention also relates to an aqueous extract of Anethum graveolens, enriched with small RNAs having a maximum length of 150 nucleotides, obtained by the method.

公开(公告)号：US11337916B2

公开(公告)日：2022-05-24

申请号：US16965511

申请日：2019-01-31

Applicant: ISP INVESTMENTS LLC ,  JAFER ENTERPRISES R&D, S.L.

Inventor： Jean-Marie Botto ,  Christophe Capallere ,  Catherine Gondran ,  Isabelle Imbert ,  Sèbastien Garnier ,  Erell Le Borgne

IPC: A61K36/00 ,  A61K8/9789 ,  A61Q19/08

Abstract: A pulp and skin extract from dried, seed-free Myrciaria dubia fruit. The Myrciaria dubia fruit has a maturity of at least 70%, a soluble solids/acidity ratio between 2.5 and 3, and it is rich in organic acids. The extract is obtained by solid-liquid extraction in a hydro-polyalcohol solvent selected from a hydro-glycerol and/or hydro-gylcolic solvent under agitation or with ultrasound. The extract is an active agent in cosmetic compositions, which reduce the signs of skin fatigue.

公开(公告)号：US10821069B2

公开(公告)日：2020-11-03

申请号：US15324299

申请日：2015-07-07

Applicant: ISP INVESTMENTS LLC ,  ELC MANAGEMENT LLC

Inventor： Frédérique Portolan ,  Valerie Lequoy ,  Jean-Marie Botto ,  Joel Mantelin ,  Isabelle Imbert ,  Nouha Domloge ,  Noelle Garcia ,  Nadine A. Pernodet ,  Kelly Dong ,  Edward Pelle ,  Carl Haney

IPC: A61Q17/04 ,  A61Q19/08 ,  A61K8/9728 ,  A61K8/9789 ,  A61K8/9794

Abstract: The invention relates to a Truffle extract for skin cosmetic use, comprising compounds having a molecular weight of less than 5 kDa. The invention also relates to a cosmetic method of treatment designed to reduce and/or correct the signs of aging and photo-aging of the skin and keratinous appendages, and to protect the skin against aggressions due to ultraviolet radiation.

公开(公告)号：US10137077B2

公开(公告)日：2018-11-27

申请号：US15107000

申请日：2015-03-06

Applicant: ISP INVESTMENTS, LLC

Inventor： Jean-Marie Botto ,  Valère Busuttil ,  Karine Cucumel ,  Neil Astles ,  Nouha Domloge

IPC: A61K36/00 ,  A61K8/98 ,  A61Q17/00 ,  A61K8/97 ,  A61Q19/00 ,  A61K35/612

Abstract: Methods of protecting skin from damage due to cold thermal stress are disclosed. The methods include topically applying a composition that includes an Artemia salina extract from rehydrated Artemia salina cysts to skin at risk of damage from thermal stress, particularly from cold thermal stress or repeated temperature variations. The composition includes a physiologically acceptable medium for delivery of the Artemia salina extract.

公开(公告)号：US11673905B2

公开(公告)日：2023-06-13

申请号：US15776232

申请日：2016-11-10

Applicant: ELC Management LLC ,  ISP Investments LLC

Inventor： Elodie Oger ,  Rachel Chabert ,  Isabelle Imbert ,  Jean-Marie Botto ,  Nouha Domloge ,  Joel Mantelin ,  Nadine Pernodet ,  Kelly Dong ,  Chia-Wen Chen

IPC: A61K8/44 ,  C07H1/08 ,  A61K8/60 ,  C07H21/02 ,  A61Q19/08 ,  A61K8/9789 ,  C12N15/10 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/9794

CPC classification number: C07H1/08 ,  A61K8/44 ,  A61K8/606 ,  A61K8/9789 ,  A61K8/9794 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07H21/02 ,  C12N15/1003 ,  C12N15/1017 ,  A61K2800/10 ,  A61K2800/30 ,  A61K2800/805

Abstract: The invention relates to a topical composition comprising an extract of Tiger lily (Lilium tigrinum) enriched in low molecular weight RNA. The invention also relates to a method of cosmetic care including the topical application a composition comprising an extract of Tiger lily (Lilium tigrinum) in a physiologically acceptable medium, in order to reduce skin signs of aging and photo-aging. The invention is also directed to a cosmetic method of treatment to improve cell viability, to improve cell protection against particulate matter and against DNA damages, and to reduce cellular senescence.

公开(公告)号：US20250161195A1

公开(公告)日：2025-05-22

申请号：US18836321

申请日：2023-02-06

Applicant: ISP INVESTMENTS LLC

Inventor： Elodie OGER ,  Laurine BERGERON ,  Laura MOURET ,  Florian LABARRADE ,  Jean-Marie Botto ,  Yolène FERREIRA ,  Marie BRULAS

IPC: A61K8/9789 ,  A61Q19/08 ,  C12P7/42

Abstract: The invention relates to processes for preparing plant extracts comprising an autofermentation step and optionally extraction steps allowing enrichment of the extracts with small molecular weight RNA. The invention also relates to compositions comprising such extracts and their cosmetic uses to combat the signs of skin aging. loss of firmness or tone. improve barrier function and hydration. lighten the skin or improve the skin's innate immune defenses and well-being in vivo.

公开(公告)号：US20210045996A1

公开(公告)日：2021-02-18

申请号：US16965511

申请日：2019-01-31

Applicant: ISP INVESTMENTS LLC ,  JAFER ENTERPRISES R&D, S.L.

Inventor： Jean-Marie Botto ,  Christophe Capallere ,  Catherine Gondran ,  Isabelle Imbert ,  Sèbastien Garnier ,  Erell Le Borgne

IPC: A61K8/9789 ,  A61Q19/08

Abstract: A pulp and skin extract from dried, seed-free Myrciaria dubia fruit. The Myrciaria dubia fruit has a maturity of at least 70%, a soluble solids/acidity ratio between 2.5 and 3, and it is rich in organic acids. The extract is obtained by solid-liquid extraction in a hydro-polyalcohol solvent selected from a hydro-glycerol and/or hydro-gylcolic solvent under conventional agitation or with ultrasound. The extract is an active in cosmetic compositions, which reduce the signs of skin fatigue.

公开(公告)号：US10478393B2

公开(公告)日：2019-11-19

申请号：US15564806

申请日：2016-03-30

Applicant: ISP Investments LLC ,  ELC Management LLC

Inventor： Frédérique Portolan ,  Jean-Marie Botto ,  Joel Mantelin ,  Isabelle Imbert ,  Nouha Domloge ,  Daniel B. Yarosh ,  Nevena Jurukovska-Karaman ,  Nadine A. Perdonet ,  Kelly Dong ,  Edward Pelle

IPC: A61K36/87 ,  A61K8/9794 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/9789

Abstract: The present invention relates to the cosmetic use of a combination of a hydrolysed rice extract and a grapeseed extract as an active agent to protect cutaneous cells from pollution. The present invention relates also to a cosmetic method of treatment for protecting skin epidermal cells from atmospheric pollution comprising applying on the skin area to be treated a composition comprising a combination of a hydrolysed rice extract and a grapeseed extract.