公开(公告)号：US11224222B2

公开(公告)日：2022-01-18

申请号：US15561222

申请日：2016-03-25

Applicant: ISP Investments LLC

Inventor： Raman Premachandran ,  Kalpa Metha ,  Jyoti Gupta ,  Najeeb H. Hakimi ,  Karen W Winkowski

IPC: A61K8/35 ,  A01N43/16 ,  A61Q19/00 ,  A61K8/49 ,  A01N25/02 ,  A61Q5/02

Abstract: What is described herein is a stable and reduced-yellowing/non-yellowing synergistic preservative composition comprising: (i) about 0.1 wt. % to about 40 wt. % of dehydroacetic acid (DHA); and about 0.1 wt. % to about 99.9 wt. % of at least one aprotic solvent. Also described herein are aqueous and non-aqueous based preservative compositions for various end-user applications, and processes for preparing and using such compositions to reduce yellowing of DHA when added to the end-user applications.

公开(公告)号：US12082582B2

公开(公告)日：2024-09-10

申请号：US17297628

申请日：2019-12-02

Applicant: ISP INVESTMENTS LLC

Inventor： Meiyan Guo ,  Karen Winkowski ,  Najeeb H. Hakimi ,  Raman Premachandran ,  Xin Qu

IPC: A01N43/28 ,  A01N31/02 ,  A01N31/14 ,  A01N37/28

CPC classification number: A01N43/28 ,  A01N31/02 ,  A01N31/14 ,  A01N37/28

Abstract: Described herein is a synergistic preservative composition used for providing broad spectrum antimicrobial activity comprising: (i) about 0.1 wt. % to about 99.9 wt. % of propylene carbonate; (ii) about 0.1 wt. % to about 99.9 wt. % of one or more organic compounds selected from the group consisting of propanediol, capryl hydroxamic acid, and isopropyl methyl phenol; and (iii) about 0.1 wt. % to 99.0 wt. % of phenoxyethanol, a preservative compound, and wherein, the composition provides synergy having Synergy Index (SI) value of the total composition from about 0.05 to about 1.0. Also described is a process for preparing said synergistic preservative composition and method of using the same.