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8 条记录 (耗时 0.035 秒)

    HYDROCHLORIDE SALT OF ((1S,2S,4R)-4--2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE
    2.
    发明申请
    HYDROCHLORIDE SALT OF ((1S,2S,4R)-4--2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE 有权
    （（1S，2S，4R）-4-（2-羟基环戊基）甲磺酸盐的盐酸盐

    公开(公告)号：US20110021544A1

    公开(公告)日：2011-01-27

    申请号：US12779331

    申请日：2010-05-13

    申请人： Ian G. Armitage ,  Reenu Chopra ,  Martin Ian Cooper ,  Marianne Langston

    发明人： Ian G. Armitage ,  Reenu Chopra ,  Martin Ian Cooper ,  Marianne Langston

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P35/02

    CPC分类号： A61K31/519 ,  C07D487/04 ,  C07B2200/13

    摘要： Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

    摘要翻译： 公开了式（I）的化合物：其结晶形式及其溶剂合物; 药物组合物，其包含药学上有效量的式（I）化合物或其结晶形式，或其溶剂合物和药学上可接受的载体或稀释剂; 以及式（I）化合物或其结晶形式或其溶剂合物用于治疗患有或经受能够通过抑制E1活化酶（特别是NAE）而改善的病理状况的患者 ，包括例如癌症。

    Mesylate salt of an IKK inhibitor
    4.
    发明申请
    Mesylate salt of an IKK inhibitor 审中-公开
    IKK抑制剂的甲磺酸盐

    公开(公告)号：US20090137579A1

    公开(公告)日：2009-05-28

    申请号：US12288596

    申请日：2008-10-22

    申请人： Frederick A. Hicks ,  Martin Ian Cooper ,  Marianne Langston ,  Adrian St. Clair Brown

    发明人： Frederick A. Hicks ,  Martin Ian Cooper ,  Marianne Langston ,  Adrian St. Clair Brown

    IPC分类号： A61K31/5377 ,  C07D413/14

    CPC分类号： C07D471/04

    摘要： The present invention is directed to the compound of formula (II), or a solvate thereof, or crystalline forms thereof; to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (II), including crystalline forms thereof, and a pharmaceutically acceptable carrier; and to the use of a compound of formula (II), or crystalline forms thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting IKK-2, and methods related thereto.

    摘要翻译： 本发明涉及式（II）化合物或其溶剂化物或其结晶形式; 涉及药物组合物，其包含药学上有效量的式（II）化合物，包括其结晶形式和药学上可接受的载体; 以及使用式（II）化合物或其结晶形式用于治疗患有或受其抑制IKK-2能够改善的病理状况的患者及其相关方法。

    Salts of an IKK inhibitor
    5.
    发明申请
    Salts of an IKK inhibitor 审中-公开
    IKK抑制剂的盐

    公开(公告)号：US20090131422A1

    公开(公告)日：2009-05-21

    申请号：US12288595

    申请日：2008-10-22

    申请人： Frederick A. Hicks ,  Martin Ian Cooper ,  Adrian St Clair Brown

    发明人： Frederick A. Hicks ,  Martin Ian Cooper ,  Adrian St Clair Brown

    IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61P29/00

    CPC分类号： C07D471/04

    摘要： The present invention is directed to the Tartrate, Mono-Hydrochloride, Malonate and p-Toluenesulfonate Salts of the compound of formula (I), or solvates thereof, or crystalline forms thereof; to a pharmaceutical composition comprising a pharmaceutically effective amount of the Salts, including crystalline forms thereof, and a pharmaceutically acceptable carrier; and to the use of the Salts, including crystalline forms thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting IKK-2, and methods related thereto.

    摘要翻译： 本发明涉及式（I）化合物或其溶剂合物或其结晶形式的酒石酸盐，单盐酸盐，丙二酸盐和对甲苯磺酸盐盐; 涉及包含药学有效量的盐，包括其结晶形式的药物组合物和药学上可接受的载体; 以及使用包括其结晶形式的盐，用于治疗患有或受其抑制IKK-2能够改善的病理状况的患者及其相关方法。