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    9-SUBSTITUTED 8-OXOADENINE COMPOUND
    3.
    发明申请
    9-SUBSTITUTED 8-OXOADENINE COMPOUND 有权
    9-取代的8-氧杂环丁烯化合物

    公开(公告)号：US20110306610A1

    公开(公告)日：2011-12-15

    申请号：US13187260

    申请日：2011-07-20

    申请人： Ayumu KURIMOTO ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    发明人： Ayumu KURIMOTO ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    IPC分类号： A61K31/522 ,  C07D413/14 ,  A61P37/08 ,  A61P37/00 ,  A61P31/12 ,  A61P35/00 ,  C07D473/18 ,  A61K31/5377

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。

    9-Substituted 8-Oxoadenine Compound
    4.
    发明申请
    9-Substituted 8-Oxoadenine Compound 有权
    9-取代的8-氧基腺嘌呤化合物

    公开(公告)号：US20140045837A1

    公开(公告)日：2014-02-13

    申请号：US14058064

    申请日：2013-10-21

    申请人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    发明人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    IPC分类号： C07D473/18

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。

    9-substituted 8-oxoadenine compound
    5.
    发明授权
    9-substituted 8-oxoadenine compound 有权
    9-取代的8-氧代腺嘌呤化合物

    公开(公告)号：US08575180B2

    公开(公告)日：2013-11-05

    申请号：US13187260

    申请日：2011-07-20

    申请人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    发明人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    IPC分类号： A61K31/52 ,  C07D473/00

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。

    9-substituted 8-oxoadenine compound
    7.
    发明授权
    9-substituted 8-oxoadenine compound 有权
    9-取代的8-氧代腺嘌呤化合物

    公开(公告)号：US08969362B2

    公开(公告)日：2015-03-03

    申请号：US14058064

    申请日：2013-10-21

    申请人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    发明人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    IPC分类号： A61K31/522 ,  C07D473/18 ,  A61K31/5377

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。

    NOVEL ADENINE COMPOUND
    9.
    发明申请
    NOVEL ADENINE COMPOUND 审中-公开
    新颖的化合物

    公开(公告)号：US20090099216A1

    公开(公告)日：2009-04-16

    申请号：US12067781

    申请日：2006-09-22

    申请人： Ian Millichip ,  Thomas McInally ,  Roger Bonnert

    发明人： Ian Millichip ,  Thomas McInally ,  Roger Bonnert

    IPC分类号： A61K31/522 ,  C07D473/18

    CPC分类号： C07D473/18

    摘要： A novel adenine compound represented by the formula (1): wherein Z represents (un)substituted alkylene, a single bond, etc.; R1 represents an (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heteroaryl group; R2 represents hydrogen or (un)substituted alkyl; R3, R4 and R5 each independently represents an (un)substituted alkyl, alkenyl, alkynyl, aryl, or heteroaryl group, provided that R3 and R5 may be bonded to each other to form a 3- to 7-membered, saturated carbocycle or heterocycle in cooperation with the adjacent carbon atom; and X represents oxygen, sulfur, SO2, NR6 (R6 represents hydrogen or alkyl), or a single bond, or a pharmaceutically acceptable salt of the compound. The compound and salt are useful as a medicine.

    摘要翻译： 由式（1）表示的新型腺嘌呤化合物：其中Z表示（un）取代的亚烷基，单键等; R1表示（un）取代的烷基，烯基，炔基，环烷基，芳基或杂芳基; R2代表氢或（未）取代的烷基; R 3，R 4和R 5各自独立地表示（未）取代的烷基，烯基，炔基，芳基或杂芳基，条件是R 3和R 5可以彼此键合以形成3-至7-元饱和碳环或杂环 与邻近的碳原子合作; X表示氧，硫，SO 2，NR 6（R 6表示氢或烷基）或单键或该化合物的药学上可接受的盐。 化合物和盐可用作药物。

    9-Substituted 8-oxoadenine compound
    10.
    发明申请
    9-Substituted 8-oxoadenine compound 有权
    9-取代的8-氧代腺嘌呤化合物

    公开(公告)号：US20070190071A1

    公开(公告)日：2007-08-16

    申请号：US10593691

    申请日：2005-03-24

    申请人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    发明人： Ayumu Kurimoto ,  Kazuki Hashimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Ian Millichip ,  Hiroki Wada ,  Roger Bonnert ,  Thomas Mcinally

    IPC分类号： A61K31/52 ,  A61K31/522 ,  C07D473/10

    CPC分类号： C07D473/18 ,  A61K31/522 ,  A61K31/5377

    摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

    摘要翻译： 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0〜2的整数，Z 1表示亚烷基，X 2， 表示氧原子，硫原子，SO 2，NR 5，CO，CONR 5，NR 5 CO和 Y 1，Y 2和Y 3独立地表示单键或亚烷基，X 1，O 2， >表示氧原子，硫原子，NR 4（R 4）是氢原子或烷基或单键，R 2表示 取代或未取代的烷基，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或 芳烷基]或其​​药学上可接受的盐。