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公开(公告)号：US08592490B2
公开(公告)日：2013-11-26
申请号：US12521386
申请日：2007-12-14
申请人： Igor Legen , Janez Kerc , Polona Jurkovic
发明人： Igor Legen , Janez Kerc , Polona Jurkovic
CPC分类号： A61K9/0095 , A61K9/1075 , A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2054 , A61K9/2095
摘要： Self-microemulsifying drug delivery systems and microemulsions used to enhance the solubility of pharmaceutical ingredients comprising a polyoxyethylene sorbitan fatty acid ester emulsifier; a fatty acid ester co-emulsifier and an oil.
摘要翻译： 用于增强包含聚氧乙烯山梨糖醇酐脂肪酸酯乳化剂的药物成分的溶解度的自微乳化药物递送系统和微乳液; 脂肪酸酯共乳化剂和油。
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公开(公告)号：US20100331356A1
公开(公告)日：2010-12-30
申请号：US12521386
申请日：2007-12-14
申请人： Igor Legen , Janez Kerc , Polona Jurkovic
发明人： Igor Legen , Janez Kerc , Polona Jurkovic
IPC分类号： A61K31/436 , A61K47/32 , A61K31/415 , A61K31/41 , A61K31/4155 , A61K31/44
CPC分类号： A61K9/0095 , A61K9/1075 , A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2054 , A61K9/2095
摘要： Self-microemulsifying drug delivery systems and microemulsions used to enhance the solubility of pharmaceutical ingredients comprising a polyoxyethylene sorbitan fatty acid ester emulsifier; a fatty acid ester co-emulsifier and an oil.
摘要翻译： 用于增强包含聚氧乙烯山梨糖醇酐脂肪酸酯乳化剂的药物成分的溶解度的自微乳化药物递送系统和微乳液; 脂肪酸酯共乳化剂和油。
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3.发明授权Process for the preparation of a pharmaceutical composition comprising ezetimibe 有权制备包含依泽替米贝的药物组合物的方法公开(公告)号：US09089486B2
公开(公告)日：2015-07-28
申请号：US13147956
申请日：2010-02-05
申请人： Janez Kerc , Miha Homar , Polona Jurkovic
发明人： Janez Kerc , Miha Homar , Polona Jurkovic
IPC分类号： A61K9/14 , A61K9/20 , A61K31/366 , A61K31/397 , A61P3/06
CPC分类号： A61K9/145 , A61K9/2018 , A61K9/2095
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a process for preparing dosage forms containing ezetimibe, comprising the steps of: a) providing a composition comprising ezetimibe, b) sieving a composition comprising a composition of step (a), c) shear mixing of the composition after step (b), preferably the mixing of the composition is carried out by high shear mixing, d) formulation into a dosage form. The present invention also relates to dosage forms containing ezetimibe and ezetimibe and simvastatin, which have been prepared according to the process according to the invention.
摘要翻译： 本发明属于制药工业领域，涉及制备含有依泽替米贝的剂型的方法，该方法包括以下步骤：a）提供包含依泽麦布的组合物，b）筛分包含步骤（a），c ）组合物在步骤（b）之后的剪切混合，优选组合物的混合通过高剪切混合进行，d）配制成剂型。 本发明还涉及根据本发明的方法制备的依泽替米贝，依泽替米贝和辛伐他汀的剂型。
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4.发明申请CONTROLLED RELEASE TAMSULOSIN HYDROCHLORIDE TABLETS AND A PROCESS OF MAKING THEM 审中-公开受控释放的羟色胺盐酸盐片及其制备方法公开(公告)号：US20110033534A1
公开(公告)日：2011-02-10
申请号：US12680135
申请日：2008-09-25
申请人： Janez Kerc , Miha Homar , Polona Jurkovic
发明人： Janez Kerc , Miha Homar , Polona Jurkovic
CPC分类号： A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2853 , A61K9/2866 , A61K31/18
摘要： The present invention relates to a controlled release preparation of tamsulosin hydrochloride comprising hydroxypropylcellulose and polyethylene oxide, and the process for making such pharmaceutical composition.
摘要翻译： 本发明涉及包含羟丙基纤维素和聚环氧乙烷的盐酸坦索罗辛的控释制剂及其制备方法。
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5.发明申请PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION COMPRISING EZETIMIBE 有权制备包含EZETIMIBE的药物组合物的方法公开(公告)号：US20120135976A1
公开(公告)日：2012-05-31
申请号：US13147956
申请日：2010-02-05
申请人： Janez Kerc , Miha Homar , Polona Jurkovic
发明人： Janez Kerc , Miha Homar , Polona Jurkovic
IPC分类号： A61K31/397 , A61P7/00
CPC分类号： A61K9/145 , A61K9/2018 , A61K9/2095
摘要： The present invention belongs to the field of pharmaceutical industry and relates to a process for preparing dosage forms containing ezetimibe, comprising the steps of: a) providing a composition comprising ezetimibe, b) sieving a composition comprising a composition of step (a), c) shear mixing of the composition after step (b), preferably the mixing of the composition is carried out by high shear mixing, d) formulation into a dosage form. The present invention also relates to dosage forms containing ezetimibe and ezetimibe and simvastatin, which have been prepared according to the process according to the invention.
摘要翻译： 本发明属于制药工业领域，涉及制备含有依泽替米贝的剂型的方法，该方法包括以下步骤：a）提供包含依泽麦布的组合物，b）筛分包含步骤（a），c ）组合物在步骤（b）之后的剪切混合，优选组合物的混合通过高剪切混合进行，d）配制成剂型。 本发明还涉及根据本发明的方法制备的依泽替米贝，依泽替米贝和辛伐他汀的剂型。
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公开(公告)号：US20110068497A1
公开(公告)日：2011-03-24
申请号：US12865479
申请日：2009-01-29
CPC分类号： A61K9/5153 , A61K9/1647 , A61K9/1694 , A61K9/5192 , B01J13/04
摘要： A method for preparing nanoparticles is provided, which comprises the steps of dissolving a polymer and, optionally, at least one additional ingredient, in an organic solvent, passing the solution through a vibrating nozzle and dropping the solution through the electrical field into an aqueous solution, which is stirred, such that nanoparticles are formed by the rapid diffusion of the solvent.
摘要翻译： 提供了一种制备纳米颗粒的方法，其包括将聚合物和任选的至少一种另外的成分溶解在有机溶剂中，使溶液通过振动喷嘴并将溶液通过电场滴入水溶液中的步骤 ，其被搅拌，使得通过溶剂的快速扩散形成纳米颗粒。
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7.发明申请GASTRORESISTANT PHARMACEUTICAL DOSAGE FORM COMPRISING N-(2-(2- PHTHALIMIDOETHOXY)-ACETYL)-L-ALANYL-D-GLUTAMIC ACID (LK-423) 审中-公开包含N-（2-（2-羟基乙酰氧基） - 乙酰基）-L-氨基-D-谷氨酰胺（LK-423）的胃肠药物剂型公开(公告)号：US20100183714A1
公开(公告)日：2010-07-22
申请号：US10599289
申请日：2005-03-24
申请人： Marija Bogataj , Ales Mrhar , Anton Lavric , Manica Cerne , Doris Tibaut , Anton Stalc , Uros Urleb , Tatjana Mateovic , Greta Cof , Janez Kerc , Rok Dreu , Fumio Yoneda , Shizuko Muraoka
发明人： Marija Bogataj , Ales Mrhar , Anton Lavric , Manica Cerne , Doris Tibaut , Anton Stalc , Uros Urleb , Tatjana Mateovic , Greta Cof , Janez Kerc , Rok Dreu , Fumio Yoneda , Shizuko Muraoka
IPC分类号： A61K9/36 , C07D209/48 , A61K9/14 , A61K38/05 , A61K9/16 , A61K9/50 , A61K9/28 , A61K9/48 , A61K9/32 , A61P1/04 , A61P1/00 , A61P29/00
CPC分类号： A61K9/5073 , A61K9/2095
摘要： The present invention relates to the pharmaceutical dosage forms which enable a controlled and/or a targeted delivery of an active substance to the selected regions of gastrointestinal tract of humans or animals. The pharmaceutical dosage forms preferably comprises the active substance N-(2(2-phthalimidoethoxy)-acetyl)-L-alanyl-D-glutamic acid (designated as LK 423). Methods of treatment of chronic inflammatory diseases of gastrointestinal tract of humans and/or animals by using the pharmaceutical dosage forms of the invention are disclosed.
摘要翻译： 本发明涉及能够将活性物质受控和/或定向递送到人或动物的所选择的胃肠道区域的药物剂型。 药物剂型优选包含活性物质N-（2（2-苯二酰亚氨基乙氧基） - 乙酰基）-L-丙氨酰-D-谷氨酸（命名为LK 423）。 公开了通过使用本发明的药物剂型治疗人和/或动物的胃肠道的慢性炎性疾病的方法。
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8.发明申请Pharmaceutical Multiparticulate Composit Ion Comprising Mycophenolic Acid or Myco Phenolate Sodium and Combination Compositions with Rapamycin 审中-公开药物多微粒复合物离子包含霉酚酸或肌醇酸钠和组合组合物与雷帕霉素公开(公告)号：US20080206322A1
公开(公告)日：2008-08-28
申请号：US11573647
申请日：2005-08-29
申请人： Dieter Becker , Jutta Beyer , Janez Kerc , Andrea Kramer , Nicoletta Loggia , Chirstian-Peter Luftensteiner , Jorg Ogorka
发明人： Dieter Becker , Jutta Beyer , Janez Kerc , Andrea Kramer , Nicoletta Loggia , Chirstian-Peter Luftensteiner , Jorg Ogorka
IPC分类号： A61K9/52 , C07D307/77 , A61K9/14 , A61K31/4353 , A61P37/06 , A61K31/343 , A61K9/22
CPC分类号： A61K9/1652 , A61K9/2054 , A61K9/2866 , A61K9/5026 , A61K9/5078 , A61K31/365 , A61K31/436 , A61K2300/00
摘要： The present invention relates to a novel composition, e.g. of mycophenolic acid, a salt or a prodrug thereof, in a modified release form.
摘要翻译： 本发明涉及一种新的组合物，例如， 的霉酚酸，其盐或前药，以改性释放形式存在。
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公开(公告)号：US20060121106A1
公开(公告)日：2006-06-08
申请号：US10545111
申请日：2004-02-20
申请人： Janez Kerc , Jerneja Opara , Maja Jenko Osel
发明人： Janez Kerc , Jerneja Opara , Maja Jenko Osel
IPC分类号： A61K31/43 , A61K31/407 , A61K9/48
CPC分类号： A61K9/0065 , A61K9/2054 , A61K9/2866 , A61K9/4808 , A61K9/4866 , A61K9/4891 , A61K9/5084 , A61K45/06
摘要： The present invention relates to a novel therapeutic system suitable for one or twice daily administration of amoxicillin and clavulanic acid. One part of the dosage is provided by at least one immediate release amoxicillin/clavulanic acid pharmaceutical composition, and the other part of the dosage is provided by at least one delayed and sustained release gastroretentive amoxicillin pharmaceutical composition.
摘要翻译： 本发明涉及适用于每天一次或两次给予阿莫西林和克拉维酸的新型治疗系统。 剂量的一部分由至少一种立即释放阿莫西林/克拉维酸药物组合物提供，另一部分剂量由至少一种延迟释放的胃滞留阿莫西林药物组合物提供。
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公开(公告)号：US09149460B2
公开(公告)日：2015-10-06
申请号：US11862470
申请日：2007-09-27
申请人： Vlasta Humar , Mateja Burjak , Rok Grahek , Mateja Salobir , Janez Kerc , Klemen Kocevar
发明人： Vlasta Humar , Mateja Burjak , Rok Grahek , Mateja Salobir , Janez Kerc , Klemen Kocevar
IPC分类号： A61K9/24 , A61K31/225 , A61K31/40 , A61K9/20 , A61K9/28
CPC分类号： A61K9/5047 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K31/40
摘要： The present invention relates to coated particles and pharmaceutical dosage forms comprising the active substances sensitive to environmental influences. The coating of the present invention provides stability and protection of the active substance to environmental influences and in particular from oxidation and/or environmental humidity by coating.
摘要翻译： 本发明涉及包含对环境影响敏感的活性物质的包衣颗粒和药物剂型。 本发明的涂层提供活性物质对于环境影响的稳定性和保护，特别是通过涂覆从氧化和/或环境湿度。
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