公开(公告)号：US08923595B2

公开(公告)日：2014-12-30

申请号：US13013209

申请日：2011-01-25

申请人： Igor Sokolov ,  Maxim Dokukin

发明人： Igor Sokolov ,  Maxim Dokukin

IPC分类号： G06K9/00 ,  G01Q60/24 ,  G01Q60/28 ,  G01Q60/34 ,  G01Q30/04 ,  B82Y35/00

CPC分类号： G06K9/00127 ,  B82Y35/00 ,  G01Q30/04

摘要： A method is described for distinguishing between cancerous and normal human cells. The method includes collecting cells; preparing cells for scanning; scanning of the prepared cells by means of atomic force microscopy; processing of the obtained images through specific algorithms; wherein the algorithms allowing one to identify whether the cell is cancerous or normal.

摘要翻译： 描述了用于区分癌细胞和正常人细胞的方法。 该方法包括收集细胞; 准备细胞进行扫描; 通过原子力显微镜扫描制备的细胞; 通过特定算法处理所获得的图像; 其中所述算法允许人们识别细胞是癌细胞还是正常细胞。

公开(公告)号：US20110182494A1

公开(公告)日：2011-07-28

申请号：US13013209

申请日：2011-01-25

申请人： Igor Sokolov ,  Maxim Dokukin

发明人： Igor Sokolov ,  Maxim Dokukin

IPC分类号： G06K9/00

CPC分类号： G06K9/00127 ,  B82Y35/00 ,  G01Q30/04

摘要： A method is described for distinguishing between cancerous and normal human cells. The method includes collecting cells; preparing cells for scanning; scanning of the prepared cells by means of atomic force microscopy; processing of the obtained images through specific algorithms; wherein the algorithms allowing one to identify whether the cell is cancerous or normal.

摘要翻译： 描述了用于区分癌细胞和正常人细胞的方法。 该方法包括收集细胞; 准备细胞进行扫描; 通过原子力显微镜扫描制备的细胞; 通过特定算法处理所获得的图像; 其中所述算法允许人们识别细胞是癌细胞还是正常细胞。

公开(公告)号：US20150314019A1

公开(公告)日：2015-11-05

申请号：US14699369

申请日：2015-04-29

申请人： Igor Sokolov ,  Shajesh Palantavida

发明人： Igor Sokolov ,  Shajesh Palantavida

IPC分类号： A61K49/00 ,  G01N33/58 ,  C09K11/06

CPC分类号： G01N33/587 ,  A61K49/0041 ,  A61K49/0052 ,  A61K49/0093 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/10 ,  C09K2211/1007 ,  C09K2211/1018 ,  C09K2211/1088 ,  G01N33/50 ,  G01N33/582 ,  Y02P20/149

摘要： A method for synthesizing ultrabright fluorescent silica particles with hydrophilic functional groups, comprising the steps of: (i) forming a first mixture comprising a plurality of nano-sized silica particles and a gelation agent; (ii) forming a second mixture by combining the first mixture with a surfactant, a plurality of fluorescent dye molecules, and water, wherein fluorescent dye molecules are encapsulated within a plurality of pores of the nano-sized silica particles; (iii) forming a third mixture by adding a co-source of silica to the second mixture, wherein the co-source of silica prevents leakage of the encapsulated fluorescent dye molecules from the pores of the nano-sized silica particles and provides hydrophilic functional groups to the silica particles while preserving the fluorescence of the silica particles; (iv) optional further functionalization of the obtained nanoparticles with functional molecules, exemplified by carboxylic groups and folic acid, and (v) removing excess fluorescent dye from the third mixture.

摘要翻译： 一种合成具有亲水性官能团的超立体荧光二氧化硅颗粒的方法，包括以下步骤：（i）形成包含多个纳米尺寸二氧化硅颗粒和凝胶剂的第一混合物; （ii）通过将第一混合物与表面活性剂，多种荧光染料分子和水组合形成第二混合物，其中荧光染料分子被包封在纳米尺寸二氧化硅颗粒的多个孔内; （iii）通过向第二混合物中加入二氧化硅的辅助源形成第三混合物，其中二氧化硅辅助源防止包封的荧光染料分子从纳米级二氧化硅颗粒的孔中泄漏并提供亲水性官能团 同时保留二氧化硅颗粒的荧光; （iv）用官能分子任选进一步官能化所得的纳米颗粒，例如羧基和叶酸，（v）从第三混合物中除去过量的荧光染料。

公开(公告)号：US20130006803A1

公开(公告)日：2013-01-03

申请号：US13174956

申请日：2011-07-01

申请人： Ilya Oskolkov ,  Artem Kirakosyan ,  Rodion Shishkov ,  Igor Sokolov

发明人： Ilya Oskolkov ,  Artem Kirakosyan ,  Rodion Shishkov ,  Igor Sokolov

IPC分类号： G06Q30/00

CPC分类号： G06Q30/02 ,  G06Q30/06

摘要： Disclosed are electronic systems and techniques for implementing lists that include source of origin information for items added to the lists. A portal can include a component that enables items to be added to lists associated with the portal from a variety of sources, such as social networks, other portals, advertisements, search engines, other users, etc. In this regard, the items can be added to a list with references to the portal, instead of the source of origin, and information relating to the source of origin can be maintained to assist users in future prioritizations of items included in the list.

摘要翻译： 公开了用于实现列表的电子系统和技术，其包括添加到列表中的项目的来源信息源。 门户可以包括一个组件，其使项目能够从诸如社交网络，其他门户，广告，搜索引擎，其他用户等的各种来源添加到与门户相关联的列表中。在这点上，项目可以是 添加到列表中，而不是源的来源，并且可以维护与源的相关信息，以帮助用户今后对列表中包含的项目进行优先排序。

公开(公告)号：US07761255B1

公开(公告)日：2010-07-20

申请号：US11713468

申请日：2007-03-02

申请人： Igor Sokolov

发明人： Igor Sokolov

IPC分类号： G01K11/30

CPC分类号： G01Q60/32 ,  G01Q30/04

摘要： The invention is an apparatus and method including hardware and software, which allows collecting and analyzing data to obtain information about mechanical properties of soft materials in a much faster way. The apparatus can be used as a stand-alone device or an add-on to the existing AFM device. The apparatus allows collecting dynamical measurements using a set of multiple frequencies of interest at once, in one measurement instead of sequential, one frequency in a time, measurements.

摘要翻译： 本发明是一种包括硬件和软件的装置和方法，其允许以更快的方式收集和分析数据以获得关于软材料的机械性质的信息。 该设备可以用作独立设备或附加到现有的AFM设备。 该装置允许一次使用一组感兴趣的频率进行动态测量，一次测量而不是一次一次的测量。

公开(公告)号：US07572424B1

公开(公告)日：2009-08-11

申请号：US11288974

申请日：2005-11-29

申请人： Igor Sokolov ,  Yaroslav Kievsky

发明人： Igor Sokolov ,  Yaroslav Kievsky

IPC分类号： C01B33/12 ,  D02G3/00

CPC分类号： C01B33/12 ,  C04B35/6224 ,  Y10T428/2913

摘要： This disclosure describes a self-assembly templating of a cationic surfactant in the presence of a silica precursor that is free of an excessive variability of the assembled shapes and has a yield approaching one hundred percent. This disclosure describes a self-assembly process that includes cooling and keeping a resultant solution at cold temperatures during the synthesis.

摘要翻译： 本公开描述了在二氧化硅前体的存在下阳离子表面活性剂的自组装模板，其不具有组装形状的过度变化并且具有接近百分之百的产率。 本公开描述了一种自组装过程，其包括在合成期间在冷的温度下冷却和保持所得溶液。

公开(公告)号：US09700498B2

公开(公告)日：2017-07-11

申请号：US15006379

申请日：2016-01-26

申请人： Igor Sokolov

发明人： Igor Sokolov

IPC分类号： A61K8/25 ,  A61Q11/00 ,  A61K8/29 ,  A61K8/02 ,  A61K8/19

CPC分类号： A61K8/25 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/29 ,  A61K2800/28 ,  A61K2800/413 ,  A61Q11/00

摘要： A method for polishing tooth surface which eases removal of a bacterial film later grown on the polished surface. The method includes the steps of providing a providing a toothpaste or slurry comprising a plurality of inorganic abrasive particles smaller than 100 nm in size, the inorganic abrasive particles comprising one or more of silica, ceria, titania, zirconia, silicon nitrite, and silica carbide, wherein the inorganic abrasive particles are sufficiently hard to be abrasive; and polishing a tooth surface with the toothpaste or slurry to attain an ultra-smooth tooth surface which can be easily cleaned.

公开(公告)号：US20160220459A1

公开(公告)日：2016-08-04

申请号：US15006379

申请日：2016-01-26

申请人： Igor Sokolov

发明人： Igor Sokolov

IPC分类号： A61K8/25 ,  A61Q11/00 ,  A61K8/02

CPC分类号： A61K8/25 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/29 ,  A61K2800/28 ,  A61K2800/413 ,  A61Q11/00

摘要： A method for polishing tooth surface which eases removal of a bacterial film later grown on the polished surface. The method includes the steps of providing a providing a toothpaste or slurry comprising a plurality of inorganic abrasive particles smaller than 100 nm in size, the inorganic abrasive particles comprising one or more of silica, ceria, titania, zirconia, silicon nitrite, and silica carbide, wherein the inorganic abrasive particles are sufficiently hard to be abrasive; and polishing a tooth surface with the toothpaste or slurry to attain an ultra-smooth tooth surface which can be easily cleaned.

摘要翻译： 一种用于抛光牙齿表面的方法，其使得随后在抛光表面上生长的细菌膜的移除。 该方法包括以下步骤：提供包括大小小于100nm的多个无机磨料颗粒的牙膏或浆料，所述无机磨料颗粒包含二氧化硅，二氧化铈，二氧化钛，氧化锆，亚硝酸亚铁和二氧化碳碳化物中的一种或多种 ，其中所述无机磨料颗粒足够难以研磨; 并用牙膏或浆料研磨牙齿表面以获得能够容易地清洁的超光滑牙齿表面。

公开(公告)号：US20140259038A1

公开(公告)日：2014-09-11

申请号：US13789378

申请日：2013-03-07

申请人： Leonid Belyaev ,  Igor Sokolov ,  Ilya Baronshin

发明人： Leonid Belyaev ,  Igor Sokolov ,  Ilya Baronshin

IPC分类号： H04N21/442

CPC分类号： H04N21/458 ,  H04N21/4622 ,  H04N21/4667 ,  H04N21/4668

摘要： Video content is identified by a source component via a processor from a plurality of media sources comprising at least two of a wireless broadcast media channel, a web site, a web data feed, and/or a wired broadcast channel for communication via a personalized video channel. A demographic component is configured to classify a user device in a demographic class based on demographic data. A set of predicted video content is generated from the video content of the plurality of media sources based on the demographic data with a prediction component. A streaming component is configured to communicate the set of predicted video content from the plurality of media sources to a mobile component via the personalized video channel and re-configure the personalized video channel to communicate, at different times, the video content identified from different media sources of the plurality of media sources.

摘要翻译： 视频内容由来自包括无线广播媒体频道，网站，网络数据馈送和/或有线广播频道中的至少两个的多个媒体源的处理器由源组件标识，用于经由个性化视频进行通信 渠道。 人口统计学组件被配置为基于人口统计学数据对人口统计学类别中的用户设备进行分类。 基于具有预测分量的人口统计数据，从多个媒体源的视频内容生成一组预测视频内容。 流分量被配置为经由个性化视频信道将来自多个媒体源的预测视频内容集合传送到移动组件，并且重新配置个性化视频频道以在不同时间在不同时间通信从不同媒体识别的视频内容 多个媒体来源。

公开(公告)号：US20120187340A1

公开(公告)日：2012-07-26

申请号：US11825313

申请日：2007-07-05

申请人： Igor Sokolov ,  Sajo Naik ,  Gary L. Vandermolen ,  Gary L. Dies

发明人： Igor Sokolov ,  Sajo Naik ,  Gary L. Vandermolen ,  Gary L. Dies

IPC分类号： C09K11/06 ,  C01B33/12

CPC分类号： C09K11/06 ,  C01B33/18 ,  C09K11/025

摘要： The object of the invention is to producing ultras bright fluorescent silica particles by synthesizing large nanopore silica particles with self sealed channels/pores and then stopping the synthesizing before large nanopore silica particles have been formed, wherein said sintering solution has produced nanoparticles. The large nanopore silica particles are micron size. The synthesizing is stopped by diluting said synthesizing solution with a neutralizing medium such as an aqueous solution of definite acidity of pH7 and higher an exemplary value of pH11 (sodium hydroxide). The time range for stopping the synthesizing ranges from tens of seconds to ten of minutes.

摘要翻译： 本发明的目的是通过合成具有自密封通道/孔的大的纳米孔二氧化硅颗粒，然后在形成大的纳米孔二氧化硅颗粒之前停止合成来制备超亮的荧光二氧化硅颗粒，其中所述的烧结溶液已经生成纳米颗粒。 大的纳米孔二氧化硅颗粒是微米尺寸的。 通过用中和介质如pH7的确定酸度的水溶液和pH11（氢氧化钠）的典型值来稀释所述合成溶液来停止合成。 停止合成的时间范围从几十秒到十分钟。