公开(公告)号：US4782055A

公开(公告)日：1988-11-01

申请号：US942379

申请日：1986-12-16

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Kazuhiko Take ,  Hiromichi Itani

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Kazuhiko Take ,  Hiromichi Itani

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/435

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to imidazopyridine compounds of the formula: ##STR1## wherein R.sup.1 is lower alkynyl or lower alkynyloxy(lower)-alkyl,R.sup.2 is lower alkyl, andR.sup.3 is ar(lower)alkyl having lower alkoxy, lower alkylthio, nitro or lower alkanesulfonyl, ar(lower)alkyl having nitro and one or two additional substituent(s) selected from nitro and lower alkyl, or heterocyclic(lower)alkyl which may have suitable substituent(s), and to their utility.The compounds have antiulcerative properties.

摘要翻译： 本发明涉及下式的咪唑并吡啶化合物：其中R 1是低级炔基或低级炔氧基（低级） - 烷基，R 2是低级烷基，R 3是具有低级烷氧基，低级烷硫基，硝基或 低级烷基磺酰基，具有硝基的芳（低级）烷基和选自硝基和低级烷基的一个或两个另外的取代基或可具有合适取代基的杂环（低级）烷基，以及它们的用途。 该化合物具有抗溃疡性质。

公开(公告)号：US4725601A

公开(公告)日：1988-02-16

申请号：US865331

申请日：1986-05-21

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Kazuhiko Take ,  Hiromichi Itani

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Kazuhiko Take ,  Hiromichi Itani

IPC分类号： A61K31/44 ,  A61K31/495 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Certain imidazo[1,2-a]heterocyclic compounds useful in the treatment of ulcers are provided.

摘要翻译： 提供了可用于治疗溃疡的某些咪唑并[1,2-a]杂环化合物。

公开(公告)号：US4692444A

公开(公告)日：1987-09-08

申请号：US836402

申请日：1986-03-05

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  A61P19/06 ,  C07D495/04

CPC分类号： C07D495/04

摘要： This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,X is --S--, ##STR2## n is an integer of 1 or 2 and A is a group of the formula: ##STR3## in which R.sup.2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

摘要翻译： 本发明提供下式的苯稠稠杂环化合物：其中R1是卤素，硝基，氨基，羟基，低级烷基，低级烷氧基或酰基氨基，X是-S-，n是 其中R 2为氢，低级烷基，低级炔基，羧基（低级）烷基或被保护的羧基（低级）烷基）或其药学上可接受的盐。 该化合物具有利尿，尿酸和血管扩张活性，因此可用作利尿剂，尿酸血症药和抗高血压药。 本发明还提供了制备该化合物的方法和包含上式化合物的药物组合物。

公开(公告)号：US4686227A

公开(公告)日：1987-08-11

申请号：US745638

申请日：1985-06-17

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

IPC分类号： C07D471/04 ,  A61K31/47 ,  A61P1/04 ,  C07D487/04 ,  A61K31/395 ,  C07D405/04

CPC分类号： C07D487/04

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in whichA is lower alkylene andR.sup.2 is di(lower)alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino (lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof.The compounds are useful as anti ulcer agents.

摘要翻译： 下式的化合物，其中R 1为低级烷基，R 3为氢，卤素或芳（低级）烷氧基，R为低级烷酰基，亚硝基，氨基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，卤代甲酰基，氨基亚甲基氨基 可以被氰基或低级烷基取代，可以被氰基或低级烷基取代的亚氨基甲基氨基，或下列基团：其中A是低级亚烷基，R2是二（低级）烷基氨基，氰基，低级烷氧基 ，可具有适当取代基的含N杂环基，低级炔氧基，低级烯氧基，低级烷硫基，氨基（低级）烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羧基，酯化羧基，氨基甲酰基，羟基氨基甲酰基，羟基，低级烷酰氧基， 具有两个氧代基的杂环氨基（低级）烷硫基，氢或下式的基团：其中R 4，R 5和R 6各自为低级烷基，X为酸残基，及其药学上可接受的盐。 该化合物可用作抗溃疡剂。

公开(公告)号：US4675324A

公开(公告)日：1987-06-23

申请号：US780582

申请日：1985-09-26

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： C07D311/22 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/435 ,  A61K31/47 ,  A61K31/4745 ,  A61P7/10 ,  A61P9/02 ,  A61P9/08 ,  A61P9/12 ,  A61P19/06 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052 ,  A61K31/395

CPC分类号： C07D215/233 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

摘要翻译： 本发明提供了下式的有益稠合的杂环化合物：其中R 1是卤素，硝基，氨基，羟基，低级烷基，被羧基或被保护的羧基取代的低级烷氧基，在氨基部分上可以具有低级烷基的酰基氨基， 或可具有卤素的芳氧基，R 2是氢或卤素，X是-O-或者其中R 3是氢，低级烷基或酰基，和A是下式的基团：其中R 4是氢， 低级烯基，低级炔基或烷基，其可以具有选自羟基，酰基，低级烷氧基，二（低级）烷基氨基，羧基，保护的羧基和芳基的合适取代基。 或R 1为氢或低级烷氧基，R 2为氢，X为R a为低级烷酰基，A为下式基团：及其药学上可接受的盐。 该化合物具有利尿活性，尿酸活性和血管舒张活性，可用作利尿剂，尿酸血症药和抗高血压药。 本发明还涉及制备该化合物的方法和包含上式化合物的药物组合物。

公开(公告)号：US4767780A

公开(公告)日：1988-08-30

申请号：US42299

申请日：1987-04-24

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： C07D311/22 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/435 ,  A61K31/47 ,  A61K31/4745 ,  A61P7/10 ,  A61P9/02 ,  A61P9/08 ,  A61P9/12 ,  A61P19/06 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052 ,  A61K31/35 ,  C07D487/04

CPC分类号： C07D215/233 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower, alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

公开(公告)号：US4738967A

公开(公告)日：1988-04-19

申请号：US945788

申请日：1986-12-23

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

IPC分类号： C07D471/04 ,  A61K31/47 ,  A61P1/04 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D487/04

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in which A is lower alkylene andR.sup.2 is di(lower) alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino(lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof. pa The compounds are useful as anti ulcer agents.

公开(公告)号：US4673676A

公开(公告)日：1987-06-16

申请号：US669865

申请日：1984-11-09

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe

IPC分类号： C07D487/04 ,  A61K31/4745 ,  A61K31/505 ,  A61P11/06 ,  C07D217/02 ,  C07D217/08 ,  C07D217/22 ,  C07D471/04

CPC分类号： C07D217/02 ,  C07D217/08 ,  C07D217/22 ,  C07D471/04

摘要： Pyrimidoisoquinoline/compounds of the formula: ##STR1## where R.sup.1 is H, halogen or lower alkyl, R.sup.2 is NH.sub.2, NO.sub.2 or acylamino and R.sup.3 is carboxy or protected carboxy, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are disclosed in this application. Also disclosed is a method of treating allergies by administering the compounds of this invention.

摘要翻译： 嘧啶并喹啉/下式的化合物：其中R 1为H，卤素或低级烷基，R 2为NH 2，NO 2或酰基氨基，R 3为羧基或被保护的羧基，其药学上可接受的盐及其药物组合物在本申请中公开。 还公开了通过施用本发明化合物治疗过敏症的方法。

公开(公告)号：US08205644B2

公开(公告)日：2012-06-26

申请号：US12733482

申请日：2008-10-06

申请人： Ikuo Ueda

发明人： Ikuo Ueda

IPC分类号： D21F1/10 ,  D21F7/08 ,  D03D25/00

CPC分类号： D21F1/0036 ,  Y10T428/24612

摘要： An industrial two-layer fabric constituted by at least one upper surface side warp to be woven with at least one upper surface side weft, at least one lower surface side warp to be woven with at least one lower surface side weft, and at least one warp binding yarn to be woven with the at least one upper surface side weft and the at least one lower surface side weft having at least one pair of upper and lower warps in which the upper and lower surface side warps are located to be upper and lower, respectively, and at least one pair of warp binding yarns in which at least one yarn constitutes a warp binding yarn.

摘要翻译： 一种工业双层织物，由至少一个上表面侧经纱与至少一个上表面侧纬纱组成，至少一个下表面侧经纱与至少一个下表面侧纬纱织造，至少一个 具有至少一个上表面侧纬纱和至少一个下表面侧纬纱的经编结合纱线具有至少一对上下翘曲，其中上表面侧经线和下表面侧经线位于其上下 以及至少一对经纱结合纱线，其中至少一根纱线构成经纱结合纱线。

公开(公告)号：US20100252137A1

公开(公告)日：2010-10-07

申请号：US12591704

申请日：2009-11-30

申请人： Ikuo Ueda

发明人： Ikuo Ueda

IPC分类号： D03D11/00

CPC分类号： D21F1/0036

摘要： A two layer fabric has first, second, third and fourth upper side wefts contiguously and repeatedly arranged. Each of three contiguously arranged warps forms a knuckle over second, over third, and over second upper side wefts respectively to form a separation portion. At both sides of the separation portion, both the second and third upper side wefts form a float portion by passing over two or more warps. Adjacent to the float portion, one warp passes over the second and third upper side wefts successively and one or two warps adjacent thereto pass over the second or the third upper side weft to form an approach portion where the second and third upper side wefts approach. Crimp portions are formed to sandwich the separation portion where the first and fourth upper side wefts pass over warps which are common to those of the separation portion.

摘要翻译： 双层织物具有连续重复布置的第一，第二，第三和第四上侧纬纱。 三个连续布置的经纱中的每一个分别在第二，第三和第二上侧纬纱上形成转向节，以形成分离部分。 在分离部分的两侧，第二和第三上侧纬纱都经过两个或多个经纱而形成浮子部分。 相邻于浮子部分，一个经纱依次穿过第二和第三上侧纬纱，并且与其相邻的一个或两个经纱穿过第二或第三上侧纬纱，以形成第二和第三上侧纬纱接近的接近部分。 压接部形成为夹着第一和第四上侧纬纱经过与分离部的纬纱共同的经纱的分离部。