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22 条记录 (耗时 0.028 秒)

    Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents
    1.
    发明授权
    Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents 失效
    取代的吡唑并[4,3-c]吡啶并且其用作尿酸，利尿和抗高血压药

    公开(公告)号：US4675324A

    公开(公告)日：1987-06-23

    申请号：US780582

    申请日：1985-09-26

    申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

    发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

    IPC分类号： C07D311/22 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/435 ,  A61K31/47 ,  A61K31/4745 ,  A61P7/10 ,  A61P9/02 ,  A61P9/08 ,  A61P9/12 ,  A61P19/06 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052 ,  A61K31/395

    CPC分类号： C07D215/233 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04

    摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

    摘要翻译： 本发明提供了下式的有益稠合的杂环化合物：其中R 1是卤素，硝基，氨基，羟基，低级烷基，被羧基或被保护的羧基取代的低级烷氧基，在氨基部分上可以具有低级烷基的酰基氨基， 或可具有卤素的芳氧基，R 2是氢或卤素，X是-O-或者其中R 3是氢，低级烷基或酰基，和A是下式的基团：其中R 4是氢， 低级烯基，低级炔基或烷基，其可以具有选自羟基，酰基，低级烷氧基，二（低级）烷基氨基，羧基，保护的羧基和芳基的合适取代基。 或R 1为氢或低级烷氧基，R 2为氢，X为R a为低级烷酰基，A为下式基团：及其药学上可接受的盐。 该化合物具有利尿活性，尿酸活性和血管舒张活性，可用作利尿剂，尿酸血症药和抗高血压药。 本发明还涉及制备该化合物的方法和包含上式化合物的药物组合物。

    1,4-Dihydro[1]benzothiopyrano[4,3-c]pyrazole derivatives, compositions containing them, and pharmacological methods of using them
    3.
    发明授权
    1,4-Dihydro[1]benzothiopyrano[4,3-c]pyrazole derivatives, compositions containing them, and pharmacological methods of using them 失效
    1,4-二氢[1]苯并噻喃并[4,3-c]吡唑衍生物，含有它们的组合物和使用它们的药理学方法

    公开(公告)号：US4692444A

    公开(公告)日：1987-09-08

    申请号：US836402

    申请日：1986-03-05

    申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

    发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

    IPC分类号： A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  A61P19/06 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,X is --S--, ##STR2## n is an integer of 1 or 2 and A is a group of the formula: ##STR3## in which R.sup.2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

    摘要翻译： 本发明提供下式的苯稠稠杂环化合物：其中R1是卤素，硝基，氨基，羟基，低级烷基，低级烷氧基或酰基氨基，X是-S-，n是 其中R 2为氢，低级烷基，低级炔基，羧基（低级）烷基或被保护的羧基（低级）烷基）或其药学上可接受的盐。 该化合物具有利尿，尿酸和血管扩张活性，因此可用作利尿剂，尿酸血症药和抗高血压药。 本发明还提供了制备该化合物的方法和包含上式化合物的药物组合物。

    Subfield coding circuit, image signal processing circuit, and plasma display
    10.
    发明申请
    Subfield coding circuit, image signal processing circuit, and plasma display 审中-公开
    子场编码电路，图像信号处理电路和等离子体显示

    公开(公告)号：US20050190124A1

    公开(公告)日：2005-09-01

    申请号：US11053201

    申请日：2005-02-09

    申请人： Takashi Manabe

    发明人： Takashi Manabe

    IPC分类号： H04N5/66 ,  G09G3/20 ,  G09G3/28 ,  G09G3/296

    CPC分类号： G09G3/2022 ,  G09G3/288 ,  G09G2360/121

    摘要： A subfield (SF) coding circuit including an SF coding cache memory, a look-up table (LUT) memory, and an SF coding control unit. The coding control unit reads setting gradation values and SF coding data from the coding cache memory for writing to the LUT memory SF by SF. The control unit accesses the LUT memory by using the gradation value of an image signal from a frame memory control unit as an address, and outputs the SF coding data corresponding to the gradation value of the image signal input to the LUT memory to a serial-to-parallel conversion unit.

    摘要翻译： 包括SF编码高速缓冲存储器，查找表（LUT）存储器和SF编码控制单元的子场（SF）编码电路。 编码控制单元从用于通过SF写入LUT存储器SF的编码高速缓冲存储器中读取设置灰度值和SF编码数据。 控制单元通过使用来自帧存储器控制单元的图像信号的灰度值作为地址来访问LUT存储器，并将与输入到LUT存储器的图像信号的灰度值相对应的SF编码数据输出到串行 - 并行转换单元。