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    Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
    1.
    发明授权
    Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism 失效
    生物体内生物化学活性高分辨率体内成像的系统和方法

    公开(公告)号：US07303741B2

    公开(公告)日：2007-12-04

    申请号：US10252311

    申请日：2002-09-23

    申请人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

    发明人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

    IPC分类号： A61B5/055

    CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/085 ,  A61K49/10 ,  A61K49/14

    摘要： This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional/metabolic information to be obtained simultaneously.

    摘要翻译： 本发明涉及用于提供生物体内生化活性的高分辨率体内成像的双功能检测剂。 使用这些双功能检测剂的方法可以包括将它们施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学 成像）。 双功能检测剂之一包括磁共振成分和光学成像成分。 磁共振成分包括始终被激活或“开启”的造影剂。 光学成像组件包括可激活的造影剂或染料，其仅在特定事件的存在下被激活或变为“开启”。 例如，光学成像组件可以被一定波长的光激活，并且（1）存在特定的生物化学标记，（2）通过酶切割，或（3）通过温度或pH的变化 周围介质。 这些双功能检测剂允许同时获得解剖学和功能性/代谢信息。

    Magnetic resonance imaging systems and methods for acquiring multi-slice gradient echo images
    5.
    发明授权
    Magnetic resonance imaging systems and methods for acquiring multi-slice gradient echo images 失效
    磁共振成像系统和获取多层梯度回波图像的方法

    公开(公告)号：US06914428B2

    公开(公告)日：2005-07-05

    申请号：US10219883

    申请日：2002-08-15

    申请人： William Dixon ,  Daniel Blezek ,  Paritosh Dhawale

    发明人： William Dixon ,  Daniel Blezek ,  Paritosh Dhawale

    IPC分类号： G01R33/54 ,  G01V3/00

    CPC分类号： G01R33/4835

    摘要： Magnetic resonance imaging (“MRI”) systems and methods for acquiring multi-slice gradient echo images having a substantially constant T1-weighting including selecting a first scan having a desired contrast associated with T1-weighting and, given a first repetition time, TR1, and a first flip angle, flip1, associated with the first scan, selecting an effective repetition time, TReff, that provides the desired contrast. The MRI systems and methods also including holding the effective repetition time, TReff, substantially constant in relation to a second scan. The MRI systems and methods further including, given a second repetition time, TR2, determining a second flip angle, flip2, and, given the second flip angle, flip2, determining the second repetition time, TR2. The MRI systems and methods still further including performing the second scan using the second repetition time, TR2, and the second flip angle, flip2, and maximizing a signal-to-noise ratio, S/N, of the second scan.

    摘要翻译： 磁共振成像（“MRI”）系统和方法，用于获取具有基本上恒定的T 1加权的多切片梯度回波图像，包括选择具有与T 1加权相关联的期望对比度的第一扫描，以及给定第一重复时间， TR 1和与第一次扫描相关联的第一翻盖1，选择提供期望对比度的有效重复时间TReff。 MRI系统和方法还包括保持有效重复时间TReff，相对于第二扫描基本上恒定。 MRI系统和方法进一步包括给定第二重复时间TR 2，确定第二翻转角翻转2，并且给定第二翻转角翻转2，确定第二重复时间TR 2。 MRI系统和方法还包括使用第二重复时间TR 2和第二翻转角翻转2执行第二次扫描，并且使第二次扫描的信噪比S / N最大化。

    Fat/water separation and fat minimization magnetic resonance imaging systems and methods
    7.
    发明授权
    Fat/water separation and fat minimization magnetic resonance imaging systems and methods 有权
    脂肪/水分离和脂肪最小化磁共振成像系统和方法

    公开(公告)号：US07099499B2

    公开(公告)日：2006-08-29

    申请号：US10219637

    申请日：2002-08-15

    申请人： Daniel Blezek ,  Paritosh Dhawale ,  William Dixon

    发明人： Daniel Blezek ,  Paritosh Dhawale ,  William Dixon

    IPC分类号： G06K9/00

    CPC分类号： G01R33/4828 ,  G01R33/5607 ,  G01R33/56563

    摘要： Systems and methods for identifying the relative contribution of fat and water signals in a magnetic resonance (“MR”) image including an algorithm operable for selecting an image signal model, selecting a scan parameter, forming a bias field estimate, applying a bias correction to a phase image, estimating the signal fraction of fat and water at each of a plurality of voxels, and forming a fat-suppressed image, a water-suppressed image, or a combination of a fat-based image and a water-based image. The (“MRI”) fat suppression systems and methods requiring only a single image acquisition including an algorithm operable for selecting a relative phase of approximately θ=π/2 or another suitable relative phase, employing an expectation maximization algorithm to classify the phase of the complex image, and projecting complex vectors into fat and water components to obtain fat and water images.

    摘要翻译： 用于识别在包括可用于选择图像信号模型的算法的磁共振（“MR”）图像中的脂肪和水信号的相对贡献的系统和方法，选择扫描参数，形成偏置场估计，将偏置校正应用于 相位图像，估计多个体素中的每一个的脂肪和水的信号分数，以及形成脂肪抑制图像，水分抑制图像或基于脂肪的图像和水基图像的组合。 （“MRI”）脂肪抑制系统和方法仅需要单个图像采集，包括可用于选择大约θ= pi / 2的相对相位的算法或另一合适的相对相位，采用期望最大化算法来分类 复杂的图像，并将复杂矢量投影到脂肪和水分中，以获得肥胖和水分图像。