公开(公告)号：US07303741B2

公开(公告)日：2007-12-04

申请号：US10252311

申请日：2002-09-23

申请人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

发明人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

IPC分类号： A61B5/055

CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/085 ,  A61K49/10 ,  A61K49/14

摘要： This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional/metabolic information to be obtained simultaneously.

摘要翻译： 本发明涉及用于提供生物体内生化活性的高分辨率体内成像的双功能检测剂。 使用这些双功能检测剂的方法可以包括将它们施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学 成像）。 双功能检测剂之一包括磁共振成分和光学成像成分。 磁共振成分包括始终被激活或“开启”的造影剂。 光学成像组件包括可激活的造影剂或染料，其仅在特定事件的存在下被激活或变为“开启”。 例如，光学成像组件可以被一定波长的光激活，并且（1）存在特定的生物化学标记，（2）通过酶切割，或（3）通过温度或pH的变化 周围介质。 这些双功能检测剂允许同时获得解剖学和功能性/代谢信息。

公开(公告)号：US20080118439A1

公开(公告)日：2008-05-22

申请号：US11875245

申请日：2007-10-19

申请人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

发明人： Ileana Hancu ,  Mohan Mark Amaratunga ,  Denyce Kramer Wicht ,  Paritosh Dhawale ,  Nadeem Ishaque ,  Faisal Ahmed Syud ,  Bruce Fletcher Johnson ,  Amy Casey Williams

IPC分类号： A61K49/06 ,  A61K49/04

CPC分类号： A61K49/0056 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/085 ,  A61K49/10 ,  A61K49/14

摘要： This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.

摘要翻译： 本发明涉及可用于提供活体内生物化学活性的高分辨率，体内成像的多功能检测剂。 使用这些多功能检测剂的方法可以包括将其施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学 成像）。 多功能检测剂之一包括磁共振成分和光学成像元件。 磁共振成分包括始终被激活或“开启”的造影剂。 光学成像组件包括多个可激活的造影剂或染料，其中至少两个不同于其中，其中可激活的造影剂中的至少一个可以在特定事件的存在下被激活或“打开” 。

公开(公告)号：US20070134159A1

公开(公告)日：2007-06-14

申请号：US11297263

申请日：2005-12-08

申请人： W. Dixon ,  Ileana Hancu

发明人： W. Dixon ,  Ileana Hancu

IPC分类号： A61K49/10 ,  A61B5/055

CPC分类号： G01R33/5601 ,  G01R33/4804 ,  G01R33/483 ,  G01R33/5605

摘要： The manipulation of RF irradiation to a subject in which a CEST agent has been administered is employed to determine a biological parameter in vivo in conjunction with an MRI imaging process. The exchange rate of the CEST agent is determined through RF manipulation which in turn enables the determination of a biological parameter through standard calibration techniques. The exchange rate of CEST agents is modulated as a function of many biological parameters, such as pH. MRI apparatuses and computer program products configured for determining exchanges rates of CEST agents in vivo are also disclosed.

摘要翻译： 使用已经给予CEST试剂的受试者的RF照射的操作来与MRI成像过程结合来确定体内的生物学参数。 通过RF操作确定CEST试剂的汇率，其进而通过标准校准技术确定生物参数。 作为许多生物参数（如pH）的函数调节CEST试剂的交换率。 还公开了配置用于确定CEST试剂在体内的交换速率的MRI装置和计算机程序产品。

公开(公告)号：US08981778B2

公开(公告)日：2015-03-17

申请号：US13094602

申请日：2011-04-26

申请人： Seung-Kyun Lee ,  Ileana Hancu ,  Lorne Wyatt Hofstetter

发明人： Seung-Kyun Lee ,  Ileana Hancu ,  Lorne Wyatt Hofstetter

IPC分类号： G01R33/48 ,  G01R33/3415 ,  G01R33/3875

CPC分类号： G01R33/3415 ,  G01R33/3875

摘要： A method of generating a magnetic resonance (MR) image includes applying a localized magnetic field to a portion of a patient, determining a difference between a local field strength around a first region of interest and a local field strength around a different second region of interest, adjusting the local field strength around the first region of interest such that the local field strength around the first region of interest is substantially the same as the local field strength around the second region of interest, and generating an image of the first and second regions after adjusting the local field strength around the first second region of interest. A coil apparatus and a system are also described herein.

摘要翻译： 产生磁共振（MR）图像的方法包括将局部磁场施加到患者的一部分，确定感兴趣的第一区域周围的局部场强与不同的第二感兴趣区域周围的局部场强之间的差异 调整围绕所述第一感兴趣区域的局部场强，使得所述第一感兴趣区周围的局部场强与所述第二感兴趣区周围的局部场强基本相同，并且产生所述第一和第二区的图像 在调整感兴趣的第一个第二区域周围的局部场强之后。 本文还描述了线圈装置和系统。

公开(公告)号：US08049501B2

公开(公告)日：2011-11-01

申请号：US12420098

申请日：2009-04-08

申请人： Ileana Hancu ,  Joseph Edward Piel ,  William Thomas Dixon

发明人： Ileana Hancu ,  Joseph Edward Piel ,  William Thomas Dixon

IPC分类号： G01V3/00

CPC分类号： G01R33/3635 ,  G01R33/281 ,  G01R33/34061 ,  G01R33/34076 ,  G01R33/3664 ,  G01R33/3678 ,  G01R33/543 ,  G01R33/5601 ,  G01R33/5611 ,  G01R33/58

摘要： A multi-frequency imaging radio frequency (RF) coil operational at three or more different frequencies, with a shifting frequency loop structure proximate the coil and switchably coupled to provide different frequencies when the loop structure is coupled to the coil. In one embodiment one of the frequencies is a proton frequency, one is a sodium frequency, and one of the frequencies is a carbon frequency. One example involves imaging examinations using hyperpolarized compounds.

摘要翻译： 一种以三个或更多个不同频率工作的多频成像射频（RF）线圈，其具有靠近线圈的移动频率环结构，并且当环路结构耦合到线圈时可切换地耦合以提供不同的频率。 在一个实施例中，频率之一是质子频率，一个是钠频率，其中一个频率是碳频率。 一个例子涉及使用超极化化合物的成像检查。

公开(公告)号：US07741844B2

公开(公告)日：2010-06-22

申请号：US11745043

申请日：2007-05-07

申请人： Ileana Hancu ,  Richard Philip Mallozzi

发明人： Ileana Hancu ,  Richard Philip Mallozzi

IPC分类号： G01V3/00 ,  A61B5/05

CPC分类号： G01R33/5601 ,  A61B5/0037 ,  A61B5/055 ,  G01R33/4633 ,  G01R33/543 ,  G01R33/583

摘要： A method and system for imaging using labeled contrast agents and a magnetic resonance imaging (MRI) scanner are provided. The method comprises performing a prescan at a frequency selected to be substantially similar to a frequency of the labeled contrast agent and performing an examination scan at the frequency of the labeled contrast agent substantially immediately after administering the labeled contrast agent to a subject.

摘要翻译： 提供了使用标记的造影剂和磁共振成像（MRI）扫描仪进行成像的方法和系统。 该方法包括以选定的频率基本上类似于标记的造影剂的频率执行预扫描，并且在对受试者施用标记的造影剂之后基本上立即以标记的造影剂的频率执行检查扫描。

公开(公告)号：US08198891B2

公开(公告)日：2012-06-12

申请号：US12484457

申请日：2009-06-15

申请人： Laura I. Sacolick ,  Mika W. Vogel ,  Florian Wiesinger ,  Ileana Hancu

发明人： Laura I. Sacolick ,  Mika W. Vogel ,  Florian Wiesinger ,  Ileana Hancu

IPC分类号： G01V3/00

CPC分类号： A61B5/055 ,  A61B5/0402 ,  G01R33/246 ,  G01R33/583

摘要： An apparatus, system, and method including a magnetic resonance imaging (MRI) apparatus includes a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images, and a computer. The computer is programmed to apply a first off-resonant radio frequency (RF) pulse at a first frequency different than the resonant frequency to a plurality of nuclei excited at a resonant frequency, acquire a first signal from the plurality of nuclei after application of the first off-resonant RF pulse, determine a phase shift from the first signal based on the first off-resonant RF pulse, determine a B1 field based on the phase shift, and store the B1 field on a computer readable storage medium.

摘要翻译： 包括磁共振成像（MRI）装置的装置，系统和方法包括具有围绕磁体的孔定位的多个梯度线圈的磁共振成像（MRI）系统，以及RF收发器系统和由RF 用于将RF信号发射到RF线圈组件以获取MR图像的脉冲模块，以及计算机。 计算机被编程为以不同于谐振频率的第一频率将第一非共振射频（RF）脉冲施加到以共振频率激励的多个核，在施加了所述多个核之后从第一信号获取第一信号 第一非共振RF脉冲，基于第一非共振RF脉冲从第一信号确定相移，基于相移确定B1场，并将B1场存储在计算机可读存储介质上。

公开(公告)号：US20100315084A1

公开(公告)日：2010-12-16

申请号：US12484457

申请日：2009-06-15

申请人： Laura I. Sacolick ,  Mika W. Vogel ,  Florian Wiesinger ,  Ileana Hancu

发明人： Laura I. Sacolick ,  Mika W. Vogel ,  Florian Wiesinger ,  Ileana Hancu

IPC分类号： G01R33/44

CPC分类号： A61B5/055 ,  A61B5/0402 ,  G01R33/246 ,  G01R33/583

摘要： An apparatus, system, and method including a magnetic resonance imaging (MRI) apparatus includes a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images, and a computer. The computer is programmed to apply a first off-resonant radio frequency (RF) pulse at a first frequency different than the resonant frequency to a plurality of nuclei excited at a resonant frequency, acquire a first signal from the plurality of nuclei after application of the first off-resonant RF pulse, determine a phase shift from the first signal based on the first off-resonant RF pulse, determine a B1 field based on the phase shift, and store the B1 field on a computer readable storage medium.

摘要翻译： 包括磁共振成像（MRI）装置的装置，系统和方法包括具有围绕磁体的孔定位的多个梯度线圈的磁共振成像（MRI）系统，以及RF收发器系统和由RF 用于将RF信号发射到RF线圈组件以获取MR图像的脉冲模块，以及计算机。 计算机被编程为以不同于谐振频率的第一频率将第一非共振射频（RF）脉冲施加到以共振频率激励的多个核，在施加了所述多个核之后从第一信号获取第一信号 第一非共振RF脉冲，基于第一非共振RF脉冲从第一信号确定相移，基于相移确定B1场，并将B1场存储在计算机可读存储介质上。

公开(公告)号：US07742800B2

公开(公告)日：2010-06-22

申请号：US11072831

申请日：2005-03-04

申请人： Ileana Hancu ,  Napapon Sailasuta ,  Ralph Eugene Hurd

发明人： Ileana Hancu ,  Napapon Sailasuta ,  Ralph Eugene Hurd

IPC分类号： A61B5/05

CPC分类号： G01R33/465 ,  A61B5/055 ,  A61B5/4088 ,  G01N33/6893 ,  G01N2800/28 ,  G01N2800/2821 ,  Y10T436/24

摘要： A method for increasing sensitivity and/or specificity of a magnetic resonance spectroscopy imaging technique for detecting a neurodegenerative disease is provided. The method includes acquiring magnetic resonance spectroscopy data from the brain of a subject, while suppressing certain metabolites in the spectrum via a data acquisition protocol, to improve quantification accuracy for the remaining metabolites, and quantifying a metabolite concentration or a metabolite concentration ratio from the spectral data as an indicator of the neurodegenerative disease.

摘要翻译： 提供了用于增加用于检测神经变性疾病的磁共振波谱成像技术的灵敏度和/或特异性的方法。 该方法包括从受试者脑中获取磁共振光谱数据，同时通过数据采集方案抑制光谱中的某些代谢物，以提高剩余代谢物的定量准确度，并从光谱中量化代谢物浓度或代谢物浓度比 数据作为神经变性疾病的指标。

公开(公告)号：US20070249928A1

公开(公告)日：2007-10-25

申请号：US11590949

申请日：2006-11-01

申请人： Daniel James Blezek ,  Ileana Hancu ,  Michelle Dumoulin ,  Richard Philip Mallozzi

发明人： Daniel James Blezek ,  Ileana Hancu ,  Michelle Dumoulin ,  Richard Philip Mallozzi

IPC分类号： A61B5/05

CPC分类号： G01R33/565 ,  A61B5/0037 ,  G01R33/485 ,  G01R33/5608 ,  G01R33/56509

摘要： The present invention provides a method and system for automatically processing longitudinal magnetic resonance (MR) images comprising obtaining a first MR image, selecting a region of interest within the first MR image, obtaining at least one subsequent MR image, applying a registration relative to the first MR image and the at least one subsequent MR image wherein the region of interest in the at least one subsequent MR image is repositioned analogously to the region of interest in the first MR image. A computer readable program is provided configured to apply a registration relative to a first MR image and an at least one subsequent MR wherein a region of interest in the at least one subsequent MR image is repositioned analogously to a region of interest in the first MR image.

摘要翻译： 本发明提供一种用于自动处理纵向磁共振（MR）图像的方法和系统，包括获得第一MR图像，选择第一MR图像内的感兴趣区域，获得至少一个后续MR图像，相对于 第一MR图像和所述至少一个后续MR图像，其中所述至少一个后续MR图像中的感兴趣区域类似于第一MR图像中的感兴趣区域重新定位。 提供了一种计算机可读程序，其被配置为相对于第一MR图像和至少一个后续MR应用注册，其中所述至少一个后续MR图像中的感兴趣区域类似于第一MR图像中的感兴趣区域重新定位 。