Method and system for designing polypeptides and polypeptide-like polymers with specific chemical and physical characteristics
    2.
    发明申请
    Method and system for designing polypeptides and polypeptide-like polymers with specific chemical and physical characteristics 审中-公开
    用于设计具有特定化学和物理特性的多肽和多肽样聚合物的方法和系统

    公开(公告)号:US20100070200A1

    公开(公告)日:2010-03-18

    申请号:US12284017

    申请日:2008-09-17

    IPC分类号: G06G7/48 G06F19/00

    CPC分类号: G16B30/00

    摘要: Embodiments of the present invention are directed to methods and systems for designing polypeptides with specific affinities for particular substrates and substances, including inorganic substrates, surfaces, and substances. One method embodiment of the present invention includes identifying an initial set of polypeptide candidates, characterizing the initial candidates with respect to desired affinities and/or other physical and chemical characteristics, and using those characterizations for developing and refining a polypeptide-scoring function that can then be applied to computationally generated polypeptide sequences in order to identify additional candidate polypeptide sequences.

    摘要翻译: 本发明的实施方案涉及用于设计具有特定亲和力的特定基质和物质(包括无机底物,表面和物质)的多肽的方法和系统。 本发明的一个方法实施方案包括鉴定关于所需亲和力和/或其他物理和化学特性表征初始候选物的初始组多肽候选物,并且使用那些用于开发和提炼多肽评分功能的特征, 应用于计算产生的多肽序列以便鉴定另外的候选多肽序列。