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    Implantable device for treating epilepsy and cardiac rhythm disorders
    1.
    发明申请
    Implantable device for treating epilepsy and cardiac rhythm disorders 有权
    用于治疗癫痫和心律失常的植入式装置

    公开(公告)号：US20070142871A1

    公开(公告)日：2007-06-21

    申请号：US11312178

    申请日：2005-12-20

    申请人： Imad Libbus ,  Andrew Kramer

    发明人： Imad Libbus ,  Andrew Kramer

    IPC分类号： A61N1/00

    CPC分类号： A61N1/362 ,  A61N1/36064 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3962

    摘要： Various aspects relate to an implantable device. Various device embodiments comprise at least one pulse generator and a controller to communicate with the pulse generator(s). The pulse generator(s) is (are) adapted to deliver a first electrical signal through at least one electrode positioned proximate to a vagus nerve and to deliver a second electrical signal through at least one electrode positioned within or proximate to the heart. The controller includes a module to provide epilepsy therapy that includes delivering the first electrical signal though the at least one electrode proximate to the vagus nerve and a module to provide a cardiac rhythm management (CRM) therapy that includes delivering the second electrical signal through at least one electrode positioned within or proximate to the heart. The CRM therapy includes at least one therapy selected from an antitachycardia therapy and a cardiac resynchronization therapy (CRT). Other aspects and embodiments are provided herein.

    摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括至少一个脉冲发生器和与脉冲发生器通信的控制器。 脉冲发生器适于通过位于迷走神经附近的至少一个电极传送第一电信号，并且通过位于心脏内或接近心脏的至少一个电极输送第二电信号。 控制器包括提供癫痫治疗的模块，其包括通过靠近迷走神经的至少一个电极递送第一电信号，以及提供心律控制（CRM）治疗的模块，其包括至少递送第二电信号 一个电极位于心脏内或靠近心脏。 CRM治疗包括至少一种选自抗心律失焦治疗和心脏再同步治疗（CRT）的治疗。 本文提供了其它方面和实施例。

    Method and apparatus for simultaneously presenting cardiac and neural signals
    5.
    发明申请
    Method and apparatus for simultaneously presenting cardiac and neural signals 审中-公开
    同时呈现心脏和神经信号的方法和装置

    公开(公告)号：US20060241725A1

    公开(公告)日：2006-10-26

    申请号：US11114246

    申请日：2005-04-25

    申请人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    发明人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    IPC分类号： A61N1/08

    CPC分类号： A61N1/365 ,  A61B5/0006 ,  A61B5/044 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/4047 ,  A61B5/742 ,  A61N1/36114 ,  A61N1/37247

    摘要： A presentation device such as a display screen or a printer provides for simultaneous presentation of temporally aligned cardiac and neural signals. At least one cardiac signal in the form of a cardiac signal trace or cardiac event markers and at least one neural signal in the form of a neural signal trace or neural event markers are simultaneously presented. The cardiac signal indicates sensed cardiac electrical activities and/or cardiac stimulation pulse deliveries. The neural signal indicates sensed neural electrical activities and/or neural stimulation pulse deliveries. In one embodiment, the presentation device is part of an external system communicating with an implantable system that senses cardiac and/or neural signals and delivers cardiac and/or neural stimulation pulses.

    摘要翻译： 诸如显示屏或打印机的呈现装置提供用于同时呈现时间上对准的心脏和神经信号。 同时呈现心脏信号迹线或心脏事件标记形式的至少一个心脏信号和神经信号轨迹或神经事件标记形式的至少一个神经信号。 心脏信号表示感测到的心脏电活动和/或心脏刺激脉冲输送。 神经信号表示感测的神经电活动和/或神经刺激脉冲输送。 在一个实施例中，呈现装置是与感测心脏和/或神经信号并传递心脏和/或神经刺激脉冲的可植入系统通信的外部系统的一部分。

    System to provide neural markers for sensed neural activity
    6.
    发明申请
    System to provide neural markers for sensed neural activity 有权
    系统为感觉神经活动提供神经标记

    公开(公告)号：US20060241697A1

    公开(公告)日：2006-10-26

    申请号：US11113773

    申请日：2005-04-25

    申请人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    发明人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    IPC分类号： A61N1/36

    CPC分类号： A61N1/37 ,  A61B5/04001 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/726 ,  A61N1/36135 ,  A61N1/3627 ,  A61N1/3702 ,  A61N1/37217 ,  A61N1/37235

    摘要： Various aspects of the present subject matter relate to a method and a device. In various embodiments of the method, a neural activity signal is sensed, a feature from the sensed neural activity signal is extracted, and a neural marker for the extracted feature is created. The neural marker includes information regarding the extracted feature. In various embodiments, the device comprises a port to receive a neural activity signal, and a feature extractor adapted to receive and process the neural activity signal to produce a neural marker that includes information for the neural activity signal. In various embodiments, the device comprises a display, a memory adapted to store a neural marker associated with a sensed neural activity signal, and a controller adapted to communicate with the memory and the display to provide a representation of the neural marker on the display. Other aspects and embodiments are provided herein.

    摘要翻译： 本主题的各个方面涉及一种方法和装置。 在该方法的各种实施例中，感测神经活动信号，提取来自所感测的神经活动信号的特征，并且创建用于提取的特征的神经标记。 神经标记包括关于提取的特征的信息。 在各种实施例中，该装置包括用于接收神经活动信号的端口，以及特征提取器，其适于接收和处理所述神经活动信号以产生神经标记，所述神经标记包括所述神经活动信号的信息。 在各种实施例中，设备包括显示器，适于存储与所感测的神经活动信号相关联的神经标记的存储器，以及适于与存储器和显示器通信以提供显示器上的神经标记的表示的控制器。 本文提供了其它方面和实施例。

    System and method for closed-loop neural stimulation
    7.
    发明申请
    System and method for closed-loop neural stimulation 有权

    公开(公告)号：US20060106429A1

    公开(公告)日：2006-05-18

    申请号：US10992319

    申请日：2004-11-18

    申请人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

    发明人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36117 ,  A61N1/08 ,  A61N1/36171

    摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.

    Neural stimulation system to prevent simultaneous energy discharges
    9.
    发明申请
    Neural stimulation system to prevent simultaneous energy discharges 有权
    神经刺激系统防止同时释放能量

    公开(公告)号：US20060241699A1

    公开(公告)日：2006-10-26

    申请号：US11110542

    申请日：2005-04-20

    申请人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    发明人： Imad Libbus ,  Andrew Kramer ,  William Linder ,  Jeffrey Stahmann

    IPC分类号： A61N1/38

    CPC分类号： A61N1/36114 ,  A61N1/3962

    摘要： Various aspects of the present subject matter relate to a system. Various embodiments of the system comprise at least one port to connect to at least one lead with at least one electrode, at least one stimulator circuit and at least one controller. The at least one stimulator circuit is connected to the at least one port and is adapted to deliver neural stimulation to a neural stimulation target using the at least one electrode. The at least one controller is adapted to determine when another energy discharge other than the neural stimulation to the neural stimulation target is occurring and to prevent delivery of the neural stimulation simultaneously with the other energy discharge. Other aspects and embodiments are provided herein.

    摘要翻译： 本主题的各个方面涉及系统。 系统的各种实施例包括至少一个端口，以连接至少一个引线与至少一个电极，至少一个刺激器电路和至少一个控制器。 所述至少一个刺激器电路连接到所述至少一个端口，并且适于使用所述至少一个电极将神经刺激递送到神经刺激靶。 所述至少一个控制器适于确定何时发生除了对神经刺激靶的神经刺激以外的其他能量放电，并且防止神经刺激与另一能量放电同时传送。 本文提供了其它方面和实施例。

    System and method for closed-loop neural stimulation
    10.
    发明申请
    System and method for closed-loop neural stimulation 有权
    闭环神经刺激的系统和方法

    公开(公告)号：US20060135998A1

    公开(公告)日：2006-06-22

    申请号：US11280940

    申请日：2005-11-16

    申请人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

    发明人： Imad Libbus ,  Andrew Kramer ,  Julia Moffitt

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36053 ,  A61N1/36117

    摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.

    摘要翻译： 各种装置实施例包括脉冲发生器，信号处理模块和控制器。 脉冲发生器适于提供要在自主神经系统（ANS）内神经模拟部位应用的神经刺激信号。 信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。 控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。 控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。 本文提供了其它方面和实施例。