公开(公告)号：US20060217772A1

公开(公告)日：2006-09-28

申请号：US11087935

申请日：2005-03-23

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew Kramer ,  Ankur Garg ,  Kristofer James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew Kramer ,  Ankur Garg ,  Kristofer James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

公开(公告)号：US08478397B2

公开(公告)日：2013-07-02

申请号：US12686704

申请日：2010-01-13

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US20100114226A1

公开(公告)日：2010-05-06

申请号：US12686704

申请日：2010-01-13

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

IPC分类号： A61N1/08 ,  A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US07660628B2

公开(公告)日：2010-02-09

申请号：US11087935

申请日：2005-03-23

申请人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

发明人： Imad Libbus ,  Qingsheng Zhu ,  Scott Vanderlinde ,  Andrew P. Kramer ,  Ankur Garg ,  Kristofer J. James

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/3621 ,  A61N1/3627

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US20080021507A1

公开(公告)日：2008-01-24

申请号：US11621194

申请日：2007-01-09

申请人： Imad Libbus ,  Qingsheng Zhu ,  Steven Girouard

发明人： Imad Libbus ,  Qingsheng Zhu ,  Steven Girouard

IPC分类号： A61N1/365

CPC分类号： A61N1/36117 ,  A61N1/36135 ,  A61N1/36564

摘要： An aspect relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy.

摘要翻译： 一个方面涉及可植入医疗系统。 系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。 刺激器包括脉冲发生器以应用压力反射刺激疗法。 检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。 通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。

公开(公告)号：US20050149133A1

公开(公告)日：2005-07-07

申请号：US10746847

申请日：2003-12-24

申请人： Imad Libbus ,  Qingsheng Zhu ,  Steven Girouard

发明人： Imad Libbus ,  Qingsheng Zhu ,  Steven Girouard

IPC分类号： A61N1/36 ,  A61N1/365 ,  A61N1/362

CPC分类号： A61N1/36117 ,  A61N1/36135 ,  A61N1/36564

摘要： An aspect of the present subject matter relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy. Other aspects are provided herein.

摘要翻译： 本主题的一个方面涉及可植入医疗系统。 系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。 刺激器包括脉冲发生器以应用压力反射刺激疗法。 检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。 通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。 本文提供了其他方面。

公开(公告)号：US20060052830A1

公开(公告)日：2006-03-09

申请号：US11268284

申请日：2005-11-03

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

IPC分类号： A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

公开(公告)号：US20050203581A1

公开(公告)日：2005-09-15

申请号：US11125501

申请日：2005-05-10

申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。

公开(公告)号：US08825155B2

公开(公告)日：2014-09-02

申请号：US13223919

申请日：2011-09-01

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362 ,  A61N1/36 ,  A61N1/368 ,  A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/36114 ,  A61N1/3625 ,  A61N1/368 ,  A61N1/3684

摘要： Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including a first pulse for delivery via a first electrode; and a second pulse for delivery via a second electrode; and wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other.

摘要翻译： 公开了可用于治疗心脏传导异常的某些方法，装置和处理器可读介质。 在一个示例中，该装置包括植入式起搏分布生成器，其被配置为产生指定的起搏电刺激曲线，用于经由靠近His束的位于心脏右心室附近的电极的电极递送至心脏，起搏曲线包括第一 用于经由第一电极传送的脉冲; 以及用于经由第二电极传送的第二脉冲; 并且其中所述第一和第二脉冲在时间上至少部分同时并且彼此极性相反。

公开(公告)号：US08326423B2

公开(公告)日：2012-12-04

申请号：US12147317

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/372

CPC分类号： A61N1/37 ,  A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, a catheter arrangement includes a fixation mechanism to attach the catheter arrangement to heart tissue, individually-addressable electrodes for providing pacing signals to the heart tissue, and an elongated structure that supports the fixation mechanism and the electrodes. The elongated structure is used to direct an end thereof to the target region in the right ventricle, and deliver an electrical pacing signal to different portions within the target region of the heart when the fixation mechanism is operative to attach to heart tissue and also when the fixation mechanism is not attaching the catheter arrangement to heart tissue.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力， 或其组合。 在一个实施例中，导管装置包括用于将导管装置附接到心脏组织的固定机构，用于向心脏组织提供起搏信号的单独寻址电极，以及支撑固定机构和电极的细长结构。 细长结构用于将其末端引导到右心室中的目标区域，并且当固定机构可操作地附接到心脏组织时，以及当心脏组织工作时，将电起搏信号递送到心脏的目标区域内的不同部分 固定机构不将导管装置附接到心脏组织。