公开(公告)号：US20160355605A1

公开(公告)日：2016-12-08

申请号：US15158510

申请日：2016-05-18

申请人： ImmunoGen, Inc.

发明人： Gillian PAYNE ,  Philip Chun ,  Daniel J. Tavares

IPC分类号： C07K16/30 ,  A61K31/537 ,  C07K16/46 ,  A61K47/48

CPC分类号： C07K16/3092 ,  A61K31/537 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6859 ,  A61K47/6869 ,  A61K47/6877 ,  A61K2039/505 ,  C07K14/4727 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/303 ,  C07K16/3069 ,  C07K16/464 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92

摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.

公开(公告)号：US20220143208A1

公开(公告)日：2022-05-12

申请号：US17463156

申请日：2021-08-31

申请人： ImmunoGen, Inc.

发明人： Christina N. CARRIGAN ,  Kathleen R. WHITEMAN ,  Gillian PAYNE ,  Sharron LADD

IPC分类号： A61K47/68 ,  C07K16/28 ,  G01N33/574

摘要： Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.

公开(公告)号：US20170348428A1

公开(公告)日：2017-12-07

申请号：US15678505

申请日：2017-08-16

申请人： ImmunoGen, Inc

发明人： Gillian PAYNE ,  Robert W. HERBST ,  Juma BRIDGEWATER

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K39/00

CPC分类号： A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides improved methods for formulating therapeutic compositions comprising an antibody drug conjugate (“ADC”) that reduce potency variability between batches of ADC and provide for administration of such therapeutic compositions within a narrow intended range.

公开(公告)号：US20170327575A1

公开(公告)日：2017-11-16

申请号：US15583281

申请日：2017-05-01

申请人： ImmunoGen, Inc.

发明人： Olga AB ,  Daniel TAVARES ,  Lingyun RUI ,  Gillian PAYNE ,  Viktor S. GOLDMAKHER

IPC分类号： C07K16/28 ,  A61K47/68 ,  C07K16/30 ,  A61K31/537 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K31/5365 ,  A61K31/537 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6889 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94 ,  C12N5/16 ,  C12N15/62 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12N2800/00

摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.