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公开(公告)号：US20150093388A1
公开(公告)日：2015-04-02
申请号：US14473828
申请日：2014-08-29
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel Tavares , Julianto Setiady , Sharron Ladd , Christina N. Carrigan , Lingyun Rui
IPC分类号： C07K16/30 , A61K47/48 , G01N33/574
CPC分类号： C07K16/30 , A61K47/48384 , A61K47/48561 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/92 , G01N33/57411 , G01N33/57415 , G01N33/57449 , G01N33/57492 , G01N2800/52
摘要： The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
摘要翻译： 本发明一般涉及结合人叶酸受体的抗体和用于基于叶酸受体1的疗法的诊断测定。 进一步提供使用抗体监测治疗的方法。
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公开(公告)号：US20170327575A1
公开(公告)日：2017-11-16
申请号：US15583281
申请日：2017-05-01
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel TAVARES , Lingyun RUI , Gillian PAYNE , Viktor S. GOLDMAKHER
IPC分类号： C07K16/28 , A61K47/68 , C07K16/30 , A61K31/537 , A61K39/00
CPC分类号： C07K16/28 , A61K31/5365 , A61K31/537 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N5/16 , C12N15/62 , C12N15/63 , C12N15/70 , C12N15/79 , C12N2800/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
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公开(公告)号：US20160146824A1
公开(公告)日：2016-05-26
申请号：US14921596
申请日：2015-10-23
申请人： ImmunoGen, Inc.
IPC分类号： G01N33/574 , A61K47/48 , C07K16/28 , C07K16/30
CPC分类号： G01N33/57492 , A61K47/6849 , C07K16/28 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/566 , G01N2333/705
摘要： The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
摘要翻译： 本发明一般涉及结合人叶酸受体1的抗体和用于基于叶酸受体1的疗法的诊断测定。 进一步提供使用抗体监测治疗的方法。
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公开(公告)号：US20160075781A1
公开(公告)日：2016-03-17
申请号：US14952659
申请日：2015-11-25
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel Tavares , Lingyun Rui , Gillian Payne , Viktor S. Goldmakher
CPC分类号： C07K16/28 , A61K31/5365 , A61K31/537 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N5/16 , C12N15/62 , C12N15/63 , C12N15/70 , C12N15/79 , C12N2800/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
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公开(公告)号：US20200046634A1
公开(公告)日：2020-02-13
申请号：US16389396
申请日：2019-04-19
申请人： ImmunoGen, Inc.
发明人： Kelli RUNNING , Robert A. MASTICO , James J. O'LEARY , Olga AB , Beni WOLF
IPC分类号： A61K9/00 , A61K45/06 , A61K31/5365 , C07K16/28 , A61K31/573 , A61K47/68
摘要： Methods of administering immunoconjugates that bind to FOLR1 are provided. The methods comprise administering an anti-FOLR1 immunoconjugate to a person in need thereof, for example, a cancer patient, at a therapeutically effective dosing regimen that results in minimal adverse effects.
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公开(公告)号：US20180003715A1
公开(公告)日：2018-01-04
申请号：US15620117
申请日：2017-06-12
申请人： ImmunoGen, Inc.
发明人： Christina N. CARRIGAN , Olga AB , Daniel TAVARES , Beni B. WOLF
IPC分类号： G01N33/574 , A61K47/68 , G01N33/566 , C07K16/28 , C07K16/30
CPC分类号： G01N33/57492 , A61K47/6849 , C07K16/28 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/566 , G01N2333/705
摘要： The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
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公开(公告)号：US20160060339A1
公开(公告)日：2016-03-03
申请号：US14819209
申请日：2015-08-05
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel Tavares , Lingyun Rui , Gillian Payne , Viktor S. Goldmakher
CPC分类号： C07K16/28 , A61K31/5365 , A61K31/537 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N5/16 , C12N15/62 , C12N15/63 , C12N15/70 , C12N15/79 , C12N2800/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
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公开(公告)号：US20130295119A1
公开(公告)日：2013-11-07
申请号：US13800835
申请日：2013-03-13
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel Tavares , Lingyun Rui , Gillian Payne , Viktor S. Goldmaker
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , A61K45/06
CPC分类号： C07K16/28 , A61K31/5365 , A61K31/537 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N5/16 , C12N15/62 , C12N15/63 , C12N15/70 , C12N15/79 , C12N2800/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
摘要翻译： 提供了与人叶酸受体1结合的新型抗癌剂，包括但不限于抗体和免疫缀合物。 进一步提供使用试剂，抗体或免疫缀合物的方法，例如抑制肿瘤生长的方法。
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公开(公告)号：US20200325240A1
公开(公告)日：2020-10-15
申请号：US16707940
申请日：2019-12-09
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel TAVARES , Julianto SETIADY , Sharron LADD , Christina N. CARRIGAN , Lingyun RUI
IPC分类号： C07K16/30 , G01N33/574 , C07K16/28 , A61K47/68
摘要： The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
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公开(公告)号：US20160096888A1
公开(公告)日：2016-04-07
申请号：US14970436
申请日：2015-12-15
申请人： ImmunoGen, Inc.
发明人： Olga AB , Daniel Tavares , Lingyun Rui , Gillian Payne , Viktor S. Goldmakher
CPC分类号： C07K16/28 , A61K31/5365 , A61K31/537 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C12N5/16 , C12N15/62 , C12N15/63 , C12N15/70 , C12N15/79 , C12N2800/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
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