公开(公告)号：US20170166868A1

公开(公告)日：2017-06-15

申请号：US15443374

申请日：2017-02-27

申请人： InGeneron, Inc. ,  ArthroDynamic Holdings, LLC

发明人： Michael Coleman ,  Ivone Bruno ,  Rudy Martinez ,  Amir Sanchez ,  Eckhard Alt ,  Frank D. Marcum ,  Paul Shealy

IPC分类号： C12N5/0775 ,  A01N1/02

CPC分类号： C12N5/0667 ,  A01N1/0221 ,  A01N1/0284 ,  A61K31/737 ,  A61K35/28 ,  C12N5/0018 ,  C12N2501/90 ,  C12N2501/905 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2539/00 ,  A61K2300/00

摘要： A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.

公开(公告)号：US20150240211A1

公开(公告)日：2015-08-27

申请号：US14707564

申请日：2015-05-08

申请人： InGeneron, Inc. ,  ArthroDynamic Technologies, Animal Health Division, Inc.

发明人： Michael Coleman ,  Ivone Bruno ,  Rudy Martinez ,  Amir Sanchez ,  Eckhard Alt ,  Frank D. Marcum ,  Paul Shealy

IPC分类号： C12N5/0775 ,  A01N1/02

CPC分类号： C12N5/0667 ,  A01N1/0221 ,  A01N1/0284 ,  A61K31/737 ,  A61K35/28 ,  C12N5/0018 ,  C12N2501/90 ,  C12N2501/905 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2539/00 ,  A61K2300/00

摘要： A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.

摘要翻译： 培养基，培养基补充剂或可溶性基质用于冷冻保存或增强培养中的再生细胞生长并维持多系分化增强。 本发明的培养基，培养基补充剂或可溶性基质包括含有硫酸化GAG的GAG组合物，例如硫酸软骨素。 可溶性基质，包含可溶性基质和细胞给药装置的细胞给药包或试剂盒及其使用方法，用于施用用于治疗关节疾病的再生细胞或包含特定GAG组合物的其他弱化或损伤的组织， 进一步提供。

公开(公告)号：US09593309B2

公开(公告)日：2017-03-14

申请号：US14707564

申请日：2015-05-08

申请人： InGeneron, Inc. ,  ArthroDynamic Technologies, Animal Health Division, Inc.

发明人： Michael Coleman ,  Ivone Bruno ,  Rudy Martinez ,  Amir Sanchez ,  Eckhard Alt ,  Frank D. Marcum ,  Paul Shealy

IPC分类号： C12N5/0775 ,  A01N1/02 ,  C12N5/00 ,  A61K31/737 ,  A61K35/28

CPC分类号： C12N5/0667 ,  A01N1/0221 ,  A01N1/0284 ,  A61K31/737 ,  A61K35/28 ,  C12N5/0018 ,  C12N2501/90 ,  C12N2501/905 ,  C12N2533/70 ,  C12N2533/80 ,  C12N2539/00 ,  A61K2300/00

摘要： A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.

摘要翻译： 培养基，培养基补充剂或可溶性基质用于冷冻保存或增强培养中的再生细胞生长并维持多系分化增强。 本发明的培养基，培养基补充剂或可溶性基质包括含有硫酸化GAG的GAG组合物，例如硫酸软骨素。 可溶性基质，包含可溶性基质和细胞给药装置的细胞给药包或试剂盒及其使用方法，用于施用用于治疗关节疾病的再生细胞或包含特定GAG组合物的其他弱化或损伤的组织， 进一步提供。