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公开(公告)号：US20190316093A1
公开(公告)日：2019-10-17
申请号：US16471551
申请日：2017-12-27
申请人： INSPHERO AG
摘要： The present invention relates to an in vitro testing platform for the study of metabolic liver disease and related therapeutic strategies, composed of an artificial spheroidal microtissue comprising at least hepatocytes and hepatic stellate cells, and at least one type of hepatic inflammatory cells and further medium and reagents capable to establish and simulate different stages of metabolic liver disease and their progression and testing preventive and therapeutic strategies by pharmacological and/or dietary interventions.
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公开(公告)号：US20230235277A1
公开(公告)日：2023-07-27
申请号：US18101751
申请日：2023-01-26
申请人： INSPHERO AG
发明人： Simon Messner , Wolfgang Moritz , Jan Lichtenberg , Jens Kelm
CPC分类号： C12N5/0062 , C12N5/0671 , C12N5/0068 , G01N33/5014 , G01N33/5067 , C12N2513/00 , C12N2533/00
摘要： A 3D tissue culture selected from the group consisting of hydrogel-based 3D tissue culture and cellular self-assembly 3D tissue culture as well as self-assembly 3D tissue culture. Additionally, disclosed is a method of preparing cells for 3D tissue culture, which method comprises the steps of plating the cells on a suitable surface, optionally, checking for their capability to adhere to said surface, discarding the cells which have not adhered to said surface, detaching the adhered cells and transferring them into a 3D tissue culture process.
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公开(公告)号：US20220073851A1
公开(公告)日：2022-03-10
申请号：US17230669
申请日：2021-04-14
申请人： INSPHERO AG
发明人： Bjoern Niggemann , Jan Lichtenberg , Wolfgang Moritz , Jens Kelm
摘要： Provided is a system and a method for propagating cells, the system comprising a multi well plate and a plate sealing means for sealing at least one well of a multiwell plate, the plate sealing means comprising at least one solid bulge or at least one bulge comprising a solid base, said at least one bulge consisting of a resilient elastomer to securely seal at least one well of the multiwell plate. Also disclosed is the use of such a system for propagating cells and the corresponding method.
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公开(公告)号：US10704016B2
公开(公告)日：2020-07-07
申请号：US15740894
申请日：2016-07-01
申请人： INSPHERO AG
发明人： Jan Lichtenberg , Wolfgang Moritz , Jens Kelm
摘要： Disclosed are devices for propagating at least one microtissue, methods for manufacturing such devices, and the use us such devices, said devices comprise at least one well, wherein said at least one well comprises an open upper section comprising an open upper end and an open lower end, and a lower section comprising an open upper end and a bottom end, wherein the upper section and the lower section are in fluid communication, and wherein the bottom end of the lower section of at least one well of said plurality of wells is provided with a well bottom, said lower section of said at least one well has a smaller cross-sectional area than the open upper section of the same well.
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公开(公告)号：US20180127698A1
公开(公告)日：2018-05-10
申请号：US15566994
申请日：2016-04-15
申请人： INSPHERO AG
发明人： Bjoern Niggemann , Jan Lichtenberg , Wolfgang Moritz , Jens Kelm
CPC分类号： C12M23/12 , B01L3/50853 , C12M23/38 , C12N5/0018
摘要： Provided is a system and a method for propagating cells, the system comprising a multi well plate and a plate sealing means for sealing at least one well of a multiwell plate, the plate sealing means comprising at least one solid bulge or at least one bulge comprising a solid base, said at least one bulge consisting of a resilient elastomer to securely seal at least one well of the multiwell plate. Also disclosed is the use of such a system for propagating cells and the corresponding method.
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公开(公告)号：US20240043808A1
公开(公告)日：2024-02-08
申请号：US18231156
申请日：2023-08-07
申请人： INSPHERO AG
CPC分类号： C12N5/0671 , C12N5/0062 , C12N5/0697 , G01N33/5067 , G01N33/5088 , C12N2503/04 , C12N2513/00 , G01N2800/52
摘要： An in vitro testing platform for the study of metabolic liver disease and related therapeutic strategies, composed of an artificial spheroidal microtissue comprising at least hepatocytes and hepatic stellate cells, and at least one type of hepatic inflammatory cells and further medium and reagents capable to establish and simulate different stages of metabolic liver disease and their progression and testing preventive and therapeutic strategies by pharmacological and/or dietary interventions.
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公开(公告)号：US11634260B2
公开(公告)日：2023-04-25
申请号：US17273961
申请日：2019-09-05
申请人： InSphero AG
发明人： Jan Lichtenberg , Olivier Frey , Wolfgang Moritz , David Fluri
摘要： Disclosed herein is a transport device comprising a first section of an outer container comprising a shell on the inside having the shape of a spherical cap with an inner diameter and an opening, wherein the opening of the spherical cap faces upwards, and an inner container having an upper section, a lower section and an inner hollow volume defined thereby, wherein at least the lower section has a spherical shape on the outside, the outer diameter of which is smaller than the inner diameter of the spherical cap of the outer container. The inner container is suitable to be arranged in the spherical cap of the outer container in a freely pivotable fashion, and is capable of accommodating a payload.
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公开(公告)号：US10982180B2
公开(公告)日：2021-04-20
申请号：US15566994
申请日：2016-04-15
申请人： INSPHERO AG
发明人： Bjoern Niggemann , Jan Lichtenberg , Wolfgang Moritz , Jens Kelm
摘要： Provided is a system and a method for propagating cells, the system comprising a multi well plate and a plate sealing means for sealing at least one well of a multiwell plate, the plate sealing means comprising at least one solid bulge or at least one bulge comprising a solid base, said at least one bulge consisting of a resilient elastomer to securely seal at least one well of the multiwell plate. Also disclosed is the use of such a system for propagating cells and the corresponding method.
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