公开(公告)号：US11780840B2

公开(公告)日：2023-10-10

申请号：US17365789

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Yanran Ai ,  Onur Atasoylu ,  Yu Bai ,  Joseph Barbosa ,  David M. Burns ,  Daniel Levy ,  Brent Douty ,  Hao Feng ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Xun Liu ,  Song Mei ,  Jun Pan ,  Haisheng Wang ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D471/14 ,  A61K31/437 ,  C07D519/00

CPC分类号： C07D471/14 ,  C07D519/00 ,  C07B2200/05

摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US11767323B2

公开(公告)日：2023-09-26

申请号：US17365686

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Kai Liu ,  Onur Atasoylu ,  Yu Bai ,  Andrew W. Buesking ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Song Mei ,  Jun Pan ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/14 ,  A61K31/437 ,  C07D519/00

CPC分类号： C07D471/14 ,  C07D519/00

摘要： The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20220169649A1

公开(公告)日：2022-06-02

申请号：US17365789

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Yanran Ai ,  Onur Atasoylu ,  Yu Bai ,  Joseph Barbosa ,  David M. Burns ,  Daniel Levy ,  Brent Douty ,  Hao Feng ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Xun Liu ,  Song Mei ,  Jun Pan ,  Haisheng Wang ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D471/14 ,  C07D519/00

摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20240150354A1

公开(公告)日：2024-05-09

申请号：US18237535

申请日：2023-08-24

申请人： Incyte Corporation

发明人： Yanran Ai ,  Onur Atasoylu ,  Yu Bai ,  Joseph Barbosa ,  David M. Burns ,  Daniel Levy ,  Brent Douty ,  Hao Feng ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Xun Liu ,  Song Mei ,  Jun Pan ,  Haisheng Wang ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D471/14 ,  C07D519/00

CPC分类号： C07D471/14 ,  C07D519/00 ,  C07B2200/05

摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20220002299A1

公开(公告)日：2022-01-06

申请号：US17365686

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Kai Liu ,  Onur Atasoylu ,  Yu Bai ,  Andrew W. Buesking ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Song Mei ,  Jun Pan ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/14 ,  C07D519/00

摘要： The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US11919908B2

公开(公告)日：2024-03-05

申请号：US17555768

申请日：2021-12-20

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Onur Atasoylu ,  Cheng-Tsung Lai ,  Padmaja Polam ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20220213108A1

公开(公告)日：2022-07-07

申请号：US17555768

申请日：2021-12-20

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Onur Atasoylu ,  Cheng-Tsung Lai ,  Padmaja Polam ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D487/04

摘要： The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.