公开(公告)号：US20190046534A1

公开(公告)日：2019-02-14

申请号：US16003210

申请日：2018-06-08

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： Hui-Yin Li ,  James D. Rodgers

IPC分类号： A61K31/519 ,  A61K9/20 ,  C07D487/04 ,  A61K9/00

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

公开(公告)号：US09376439B2

公开(公告)日：2016-06-28

申请号：US14270915

申请日：2014-05-06

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： James D. Rodgers ,  Hui-Yin Li

IPC分类号： A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D487/04

CPC分类号： A61K31/519 ,  A61K9/0053 ,  A61K9/20 ,  C07B2200/07 ,  C07B2200/13 ,  C07D487/04

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

摘要翻译： 本发明提供（R）-3-（4-（7H-吡咯并[2,3-d]嘧啶-4-基）-1H-吡唑-1-基）-3-环戊基丙腈的盐形式，其可用于 Janus激酶活性的调节，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

公开(公告)号：US20220288078A1

公开(公告)日：2022-09-15

申请号：US17536925

申请日：2021-11-29

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： Hui-Yin Li ,  James D. Rodgers

IPC分类号： A61K31/519 ,  A61P17/12 ,  A61P17/06 ,  A61P17/08 ,  C07D487/04 ,  A61K9/00 ,  A61K9/20

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

公开(公告)号：US20230043959A1

公开(公告)日：2023-02-09

申请号：US17674237

申请日：2022-02-17

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Taisheng Huang ,  Chu-Biao Xue ,  Hui-Yin Li ,  Qun Li ,  Anlai Wang ,  Lingquan Kong ,  Hai Fen Ye ,  Wenqing Yao ,  James D. Rodgers ,  Stacey Shepard ,  Haisheng Wang ,  Lixin Shao

IPC分类号： A61K31/4545 ,  C07D487/04 ,  A61P1/00 ,  A61P11/00 ,  A61P35/00 ,  A61P11/06 ,  A61P27/02 ,  A61P17/04 ,  A61P37/06 ,  C07D401/14 ,  C07D405/14 ,  A61K9/00 ,  A61K31/519

摘要： The present invention provides piperidin-4-y1 azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：US09464088B2

公开(公告)日：2016-10-11

申请号：US14289121

申请日：2014-05-28

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Taisheng Huang ,  Chu-Biao Xue ,  Hui-Yin Li ,  Qun Li

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  A61K31/437 ,  A61P35/02 ,  A61P35/04 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  A61P3/10 ,  A61P17/06 ,  A61P17/00 ,  C07D519/00

CPC分类号： A61K31/4545 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0048 ,  A61K31/519 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P27/02 ,  A61P35/00 ,  C07B2200/13 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

摘要翻译： 本发明提供哌啶-4-基氮杂环丁烷衍生物及其组合物和使用方法，其调节Janus激酶1（JAK1）的活性，并且可用于治疗与JAK1的活性相关的疾病，包括对于 例如炎症性疾病，自身免疫性疾病，癌症和其它疾病。

公开(公告)号：US20160339031A1

公开(公告)日：2016-11-24

申请号：US15164518

申请日：2016-05-25

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： James D. Rodgers ,  Hui-Yin Li

IPC分类号： A61K31/519 ,  A61K9/20 ,  A61K9/00

CPC分类号： A61K31/519 ,  A61K9/0053 ,  A61K9/20 ,  C07B2200/07 ,  C07B2200/13 ,  C07D487/04

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

摘要翻译： 本发明提供（R）-3-（4-（7H-吡咯并[2,3-d]嘧啶-4-基）-1H-吡唑-1-基）-3-环戊基丙腈的盐形式，其可用于 Janus激酶活性的调节，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。

公开(公告)号：US11213528B2

公开(公告)日：2022-01-04

申请号：US16806244

申请日：2020-03-02

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： Hui-Yin Li ,  James D. Rodgers

IPC分类号： A61K31/519 ,  A61P17/12 ,  A61P17/06 ,  A61P17/08 ,  C07D487/04 ,  A61K9/00 ,  A61K9/20

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

公开(公告)号：US20180353499A1

公开(公告)日：2018-12-13

申请号：US15995323

申请日：2018-06-01

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Taisheng Huang ,  Chu-Biao Xue ,  Hui-Yin Li ,  Qun Li ,  Anlai Wang ,  Lingquan Kong ,  Hai Fen Ye ,  Wenqing Yao ,  James D. Rodgers ,  Stacey Shepard ,  Haisheng Wang ,  Lixin Shao

IPC分类号： A61K31/4545 ,  C07D487/04 ,  A61P11/06 ,  A61P1/00 ,  A61P27/02 ,  C07D405/14 ,  C07D401/14 ,  A61K31/519 ,  A61K9/00 ,  A61P35/00 ,  A61P11/00 ,  C07D471/04 ,  C07D519/00

摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：US10016429B2

公开(公告)日：2018-07-10

申请号：US15164518

申请日：2016-05-25

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： James D. Rodgers ,  Hui-Yin Li

IPC分类号： A61K31/519 ,  A61P37/06 ,  C07D487/04 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K31/519 ,  A61K9/0053 ,  A61K9/20 ,  C07B2200/07 ,  C07B2200/13 ,  C07D487/04

摘要： The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

公开(公告)号：US20170246157A1

公开(公告)日：2017-08-31

申请号：US15288641

申请日：2016-10-07

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Taisheng Huang ,  Chu-Biao Xue ,  Hui-Yin Li ,  Qun Li ,  Anlai Wang ,  Lingquan Kong ,  Hai Fen Ye ,  Wenqing Yao ,  James D Rodgers ,  Stacey Shepard ,  Haisheng Wang ,  Lixin Shao

IPC分类号： A61K31/4545 ,  A61K9/00

CPC分类号： A61K31/4545 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0048 ,  A61K31/519 ,  A61P1/00 ,  A61P11/00 ,  A61P11/06 ,  A61P27/02 ,  A61P35/00 ,  C07B2200/13 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.