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公开(公告)号：US20210025901A1
公开(公告)日：2021-01-28
申请号：US16827001
申请日：2020-03-23
发明人： James R. Heath , Heather Agnew , Blake Farrow , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das , Bert Tsunyin Lai , Suresh Mark Pitram
摘要： The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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2.发明申请公开(公告)号：US20180364253A1
公开(公告)日：2018-12-20
申请号：US16010347
申请日：2018-06-15
发明人： Heather Agnew , Bert Tsunyin Lai , Suresh Mark Pitram , Blake Farrow , James R. Heath , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das
摘要： The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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公开(公告)号：US11719705B2
公开(公告)日：2023-08-08
申请号：US16010347
申请日：2018-06-15
发明人： Heather Agnew , Bert Tsunyin Lai , Suresh Mark Pitram , Blake Farrow , James R. Heath , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das
CPC分类号： G01N33/6869 , C07K7/06 , C07K14/54
摘要： The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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公开(公告)号：US10598671B2
公开(公告)日：2020-03-24
申请号：US15211759
申请日：2016-07-15
发明人： James R. Heath , Heather Agnew , Blake Farrow , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das , Bert Tsunyin Lai , Suresh Mark Pitram
摘要： The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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5.发明申请IL-17F-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开IL-17F特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20170052199A1
公开(公告)日：2017-02-23
申请号：US15211759
申请日：2016-07-15
发明人： James R. Heath , Heather Agnew , Blake Farrow , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das , Bert Tsunyin Lai , Suresh Mark Pitram
CPC分类号： G01N33/6869 , C07K7/06 , C07K7/64 , C07K14/54 , C07K2319/00 , G01N2333/54
摘要： The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
摘要翻译： 本申请提供稳定的基于肽的IL-17F捕获剂和用作检测剂的方法。 该应用进一步提供了制造IL-17F捕获剂的方法。
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公开(公告)号：US10221214B2
公开(公告)日：2019-03-05
申请号：US14949236
申请日：2015-11-23
申请人： INDI MOLECULAR, INC.
发明人： James R. Heath , Arundhati Nag , Samir Das , Kaycie M. Deyle , Steven Wesley Millward , Paul Edward Kearney
IPC分类号： C07K7/02 , C12Q1/48 , A61K38/00 , A61K38/08 , A61K49/00 , A61K51/08 , C07K14/00 , C12N15/10 , C12Q1/6804 , G01N33/573 , G01N33/574
摘要： The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
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7.发明申请AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开AKT特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20160251397A1
公开(公告)日：2016-09-01
申请号：US14949236
申请日：2015-11-23
申请人： INDI MOLECULAR, INC.
发明人： James R. Heath , Arundhati Nag , Samir Das , Kaycie M. Deyle , Steven Wesley Millward , Paul Edward Kearney
IPC分类号： C07K7/02 , A61K51/08 , G01N33/574
CPC分类号： C07K7/02 , A61K38/00 , A61K38/08 , A61K49/0043 , A61K49/0056 , A61K51/08 , C07K14/001 , C12N15/1058 , C12Q1/485 , C12Q1/6804 , G01N33/573 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N2333/91205 , G01N2333/91215
摘要： The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
摘要翻译： 本申请提供稳定的基于肽的Akt捕获剂及其用作检测，诊断和治疗剂。 该应用进一步提供了使用迭代在珠粒原位点击化学开发稳定的基于肽的捕获剂（包括Akt捕获剂）的新方法。
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公开(公告)号：US20190177367A1
公开(公告)日：2019-06-13
申请号：US16280953
申请日：2019-02-20
申请人： Indi Molecular, Inc.
发明人： James R. Heath , Arundhati Nag , Samir Das , Kaycie M. Deyle , Steven Wesley Millward , Paul Edward Kearney
IPC分类号： C07K7/02 , G01N33/573 , A61K38/08 , A61K49/00 , G01N33/574 , C12Q1/6804 , C12Q1/48 , C12N15/10 , C07K14/00 , A61K51/08
摘要： The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
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公开(公告)号：US20220380409A1
公开(公告)日：2022-12-01
申请号：US17844456
申请日：2022-06-20
发明人： James R. Heath , Rosemary Dyane Rohde , Arundhati Nag , Samir Das , Aiko Umeda
IPC分类号： C07K7/64 , A61K49/00 , C07K5/06 , C07K5/08 , A61K51/08 , C07K1/04 , C07K5/10 , C07K7/56 , C07K14/00 , G01N33/573 , G01N33/68
摘要： Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.
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公开(公告)号：US10913774B2
公开(公告)日：2021-02-09
申请号：US16031840
申请日：2018-07-10
发明人： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
IPC分类号： A61K38/00 , C07K7/64 , G01N33/574 , C07K14/82 , C07K7/06
摘要： Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
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