公开(公告)号：US20210076647A1

公开(公告)日：2021-03-18

申请号：US16855905

申请日：2020-04-22

Applicant: Indiana University Research and Technology Corporation

Inventor： A. Joseph Tector

IPC: A01K67/027 ,  C12N9/10 ,  A61K35/407 ,  C12N15/85 ,  C12N9/02 ,  C12N9/22 ,  C12N9/40 ,  C12N15/877 ,  C12N15/90

Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.

公开(公告)号：US20180153146A1

公开(公告)日：2018-06-07

申请号：US15848870

申请日：2017-12-20

Applicant: Indiana University Research and Technology Corporation

Inventor： A. Joseph Tector

IPC: A01K67/027 ,  C12N15/90 ,  C12N15/877 ,  C12N15/85 ,  C12N9/40 ,  C12N9/22 ,  C12N9/10 ,  C12N9/02 ,  A61K35/407

CPC classification number: A01K67/0276 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/108 ,  A01K2267/025 ,  A61K35/407 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1048 ,  C12N9/22 ,  C12N9/2465 ,  C12N15/8509 ,  C12N15/8778 ,  C12N15/907

Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.

公开(公告)号：US11666039B2

公开(公告)日：2023-06-06

申请号：US16855905

申请日：2020-04-22

Applicant: Indiana University Research and Technology Corporation

Inventor： A. Joseph Tector

IPC: A01K67/027 ,  C12N15/877 ,  C12N9/10 ,  C12N9/22 ,  C12N9/40 ,  C12N9/02 ,  A61K35/407 ,  C12N15/85 ,  C12N15/90

CPC classification number: A01K67/0276 ,  A61K35/407 ,  C12N9/0071 ,  C12N9/1048 ,  C12N9/22 ,  C12N9/2465 ,  C12N15/8509 ,  C12N15/8778 ,  C12N15/907 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/108 ,  A01K2267/025 ,  C07K2319/80

Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.

公开(公告)号：US10667500B2

公开(公告)日：2020-06-02

申请号：US15848870

申请日：2017-12-20

Applicant: Indiana University Research and Technology Corporation

Inventor： A. Joseph Tector

IPC: A01K67/027 ,  A61K35/407 ,  C12N15/85 ,  C12N15/877 ,  C12N15/90 ,  C12N9/02 ,  C12N9/10 ,  C12N9/22 ,  C12N9/40

Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.

公开(公告)号：US20170251646A1

公开(公告)日：2017-09-07

申请号：US15446742

申请日：2017-03-01

Applicant: Indiana University Research and Technology Corporation

Inventor： A. Joseph Tector

IPC: A01K67/027

CPC classification number: A01K67/0276 ,  A01K67/0273 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/025

Abstract: The application provides methods of improving a medication related side effect in a human after transplant of transgenic organs, tissues or cells from transgenic pigs with a disrupted cellular transport gene or genes, and porcine organs, tissues, and cells therefrom are provided.