公开(公告)号：US20200095557A1

公开(公告)日：2020-03-26

申请号：US16580954

申请日：2019-09-24

Applicant: Indiana University Research and Technology Corporation

Inventor： Nicanor I. Moldovan ,  Mervin C. Yoder ,  Nutan Prasain

IPC: C12N5/071 ,  C12N5/00 ,  C12N5/077

Abstract: Co-culture of isolated human induced pluripotent stem cell (iPSC)-derived endothelial and smooth-muscle progenitor cells results in the formation of cellular spheroids having capillary-like structures (referred to herein as ‘capillary fragments’) at their core. Bioprinting of these spheroids into scaffold-free tissue constructs facilitates the development of microvasculature within the engineered tissue. Methods of using these bioprinted engineered tissues for cell therapy are also disclosed.