公开(公告)号：US10238627B2

公开(公告)日：2019-03-26

申请号：US15889409

申请日：2018-02-06

Applicant: Indiana University Research and Technology Corporation ,  Gachon University of Industry-Academic Cooperation Foundation

Inventor： Timothy W. Corson ,  Halesha D. Basavarajappa ,  Seung-Yong Seo ,  Bit Lee ,  Xiang Fei

IPC: A61K31/352 ,  A61K9/00 ,  A61P35/00

Abstract: Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

公开(公告)号：US11723886B2

公开(公告)日：2023-08-15

申请号：US16968009

申请日：2019-02-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mark R. Kelley ,  Timothy W. Corson

IPC: A61K31/165 ,  A61P27/02 ,  A61K31/445 ,  A61K31/45 ,  A61K31/675 ,  A61K45/06

CPC classification number: A61K31/165 ,  A61K31/445 ,  A61K31/45 ,  A61K31/675 ,  A61K45/06 ,  A61P27/02

Abstract: [[(2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide] (APX2009) and (2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronapthalen-2-yl)methylidene]-N-methoxypentanamide] (APX2014) for inhibiting ocular diseases are disclosed herein.

公开(公告)号：US20210393556A1

公开(公告)日：2021-12-23

申请号：US16968009

申请日：2019-02-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mark R. Kelley ,  Timothy W. Corson

IPC: A61K31/165 ,  A61K45/06 ,  A61P27/02 ,  A61K31/675 ,  A61K31/45 ,  A61K31/445

Abstract: [[(2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide] (APX2009) and (2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronapthalen-2-yl)methylidene]-N-methoxypentanamide] (APX2014) for inhibiting ocular diseases are disclosed herein.

公开(公告)号：US10738024B2

公开(公告)日：2020-08-11

申请号：US14888117

申请日：2014-05-06

Applicant: Indiana University Research and Technology Corporation ,  Gachon University of Industry-Academic Cooperation Foundation

Inventor： Timothy W. Corson ,  Halesha D. Basavarajappa ,  Seung-Yong Seo ,  Bit Lee ,  Xiang Fei

IPC: C07D311/22 ,  C07D313/08 ,  C07D217/24 ,  C07D495/04 ,  C07D405/06 ,  C07C49/84 ,  C07C49/755

Abstract: Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

公开(公告)号：US12161642B2

公开(公告)日：2024-12-10

申请号：US17051018

申请日：2019-04-30

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  Gachon University of Industry-Academic Cooperation

Inventor： Timothy W. Corson ,  Kamakshi Sishtla ,  Seung-Yong Seo ,  Bit Lee

IPC: A61K31/519 ,  A61K31/122 ,  A61K31/155 ,  A61K31/343 ,  A61K31/37 ,  A61K31/4025 ,  A61K31/409 ,  A61K31/4196 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/49 ,  A61K38/17 ,  A61K39/395 ,  A61K41/00 ,  A61K45/06 ,  A61P27/02 ,  C07D249/14 ,  C07D487/04 ,  C07K16/22 ,  C12N15/113 ,  A61K39/00

Abstract: The invention relates to a method of treatment of a patient with a ferrochelatase inhibitor, or a pharmaceutically acceptable salt thereof, or a derivative thereof. Also, the invention relates to a method of treatment of a patient with a ferrochelatase inhibitor that is a triazolopyrimidinone, or a derivative thereof, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230330046A1

公开(公告)日：2023-10-19

申请号：US18341077

申请日：2023-06-26

Applicant: Indiana University Research and Technology Corporation

Inventor： Mark R. Kelley ,  Timothy W. Corson

IPC: A61K31/165 ,  A61P27/02 ,  A61K31/445 ,  A61K31/45 ,  A61K31/675 ,  A61K45/06

CPC classification number: A61K31/165 ,  A61P27/02 ,  A61K31/445 ,  A61K31/45 ,  A61K31/675 ,  A61K45/06

Abstract: Apurinic/apyrimidinic endonuclease 1 redox factor 1 (APE1/Ref-1) inhibitors for inhibiting ocular diseases are disclosed herein.

公开(公告)号：US20210379012A1

公开(公告)日：2021-12-09

申请号：US17051807

申请日：2019-04-29

Applicant: Indiana University Research and Technology Corporation ,  Gachon University of Industry-Academic Cooperation Foundation ,  KINGSTON UNIVERSITY ,  UNIVERSITY OF SURREY

Inventor： Timothy W. Corson ,  Seung-Yong SEO ,  Bit Lee ,  Sianne SCHWIKKARO ,  Dulcie MULHOLLAND ,  Hannah WHITMORE

IPC: A61K31/353 ,  C07D309/06 ,  A61K31/7072 ,  A61K38/17 ,  A61K39/395 ,  A61K31/506 ,  A61K31/44 ,  A61K31/427

Abstract: A novel chromane derivative, (3′-hydroxy-4′-ethoxybenzyl)-5,6,7-trimethoxy-2H-1-benzopyran (SH-17059 (1)) is disclosed herein. This chromane derivative has been found to inhibit blood vessel cell growth and proliferation, providing a promising treatment for ocular angiogenesis-mediated diseases.

公开(公告)号：US20180177758A1

公开(公告)日：2018-06-28

申请号：US15889409

申请日：2018-02-06

Applicant: Indiana University Research and Technology Corporation ,  Gachon University of Industry-Academic Cooperation Foundation

Inventor： Timothy W. Corson ,  Halesha D. Basavarajappa ,  Seung-Yong Seo ,  Bit Lee ,  Xiang Fei

IPC: A61K31/352 ,  A61K9/00 ,  A61P35/00

CPC classification number: A61K31/352 ,  A61K9/0019 ,  A61K9/0048 ,  A61P35/00

Abstract: Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.