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公开(公告)号:US08507667B2
公开(公告)日:2013-08-13
申请号:US13570486
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew O. Duffey , Amy M. Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew O. Duffey , Amy M. Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120309743A1
公开(公告)日:2012-12-06
申请号:US13570486
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , A61P35/00 , A61N5/10 , A61P37/00 , A61P29/00 , A61P35/02 , C07D487/04 , A61P25/28
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08268992B2
公开(公告)日:2012-09-18
申请号:US13173161
申请日:2011-06-30
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20100179126A1
公开(公告)日:2010-07-15
申请号:US12631144
申请日:2009-12-04
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US07998952B2
公开(公告)日:2011-08-16
申请号:US12631144
申请日:2009-12-04
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04 , A61K31/55
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120302551A1
公开(公告)日:2012-11-29
申请号:US13570518
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , C07D413/04 , C07D401/06 , C07D211/56 , A61N5/10 , A61P29/00 , A61P37/00 , A61P35/00 , A61P35/02 , C07D401/04 , C07D487/04 , A61P25/28
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
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公开(公告)号:US20110257157A1
公开(公告)日:2011-10-20
申请号:US13173161
申请日:2011-06-30
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , A61P25/00 , A61P29/00 , C07D487/04 , A61P35/00
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120142732A1
公开(公告)日:2012-06-07
申请号:US13206671
申请日:2011-08-10
申请人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
发明人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
IPC分类号: A61K31/443 , C07D413/14 , A61K31/4439 , C07D413/04 , A61K31/422 , A61K31/444 , C07D405/14 , A61K31/4545 , C07D409/14 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/08 , A61P7/02 , A61P9/12 , A61P9/04 , C07D405/04
CPC分类号: A61K31/422 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2和G1如说明书中所述。 这些化合物是VPS34和/或PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08859768B2
公开(公告)日:2014-10-14
申请号:US13206671
申请日:2011-08-10
申请人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
发明人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
IPC分类号: C07D239/02 , C07D241/02 , C07D213/22 , C07D413/00 , C07D401/00 , A61K31/505 , A61K31/44 , A61K31/42 , A61K31/422 , C07D413/14 , C07D417/14 , C07D413/04
CPC分类号: A61K31/422 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2和G1如说明书中所述。 这些化合物是VPS34和/或PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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10.
公开(公告)号:US20130204006A1
公开(公告)日:2013-08-08
申请号:US13814592
申请日:2010-10-25
申请人: Herve Richard , Patricio Guerreiro , Jianping Guo , Wensheng Tang
发明人: Herve Richard , Patricio Guerreiro , Jianping Guo , Wensheng Tang
IPC分类号: C07F7/08
CPC分类号: C07F7/0879 , C07D249/20 , C07F7/0838
摘要: A process for preparing a siloxane compound comprising a 2-hydroxyphenyl benzotriazole function which comprises at least one step in which a reaction for hydrosilylation of a compound 2-hydroxyphenyl benzotriazole comprising a substituent having a terminal double bond with a siloxane compound comprising an SiH function is carried out in the presence of a catalyst and of at least one volatile organic solvent corresponding to one of formula (VII) or (VIII). in which R4 and R5, which may be identical or different, represent a linear or branched C1-C4 alkyl radical, with the proviso that the sum of the carbons of R4 and R5 is less than or equal to 6; y is and integer between 1 and 3; R6 which may be identical or different, are linear or branched C1-C3 alkyl radicals, with the proviso that the sum of the carbons of R6 is less than or equal to 6 is disclosed.
摘要翻译: 一种制备包含2-羟基苯基苯并三唑功能的硅氧烷化合物的方法,其包含至少一个步骤,其中包含具有末端双键的取代基的化合物2-羟基苯基苯并三唑与包含SiH官能团的硅氧烷化合物的氢化硅烷化反应是 在催化剂和对应于式(VII)或(VIII)之一的至少一种挥发性有机溶剂的存在下进行。 其中可以相同或不同的R 4和R 5表示直链或支链C 1 -C 4烷基,条件是R 4和R 5的碳的总和小于或等于6; y为1和3之间的整数; 可以相同或不同的R 6是直链或支链C 1 -C 3烷基,条件是R6的碳原子总数小于或等于6。
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