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公开(公告)号:US08507667B2
公开(公告)日:2013-08-13
申请号:US13570486
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew O. Duffey , Amy M. Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew O. Duffey , Amy M. Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120309743A1
公开(公告)日:2012-12-06
申请号:US13570486
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , A61P35/00 , A61N5/10 , A61P37/00 , A61P29/00 , A61P35/02 , C07D487/04 , A61P25/28
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08268992B2
公开(公告)日:2012-09-18
申请号:US13173161
申请日:2011-06-30
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20100179126A1
公开(公告)日:2010-07-15
申请号:US12631144
申请日:2009-12-04
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120302551A1
公开(公告)日:2012-11-29
申请号:US13570518
申请日:2012-08-09
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , C07D413/04 , C07D401/06 , C07D211/56 , A61N5/10 , A61P29/00 , A61P37/00 , A61P35/00 , A61P35/02 , C07D401/04 , C07D487/04 , A61P25/28
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
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公开(公告)号:US20110257157A1
公开(公告)日:2011-10-20
申请号:US13173161
申请日:2011-06-30
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: A61K31/55 , A61P25/00 , A61P29/00 , C07D487/04 , A61P35/00
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US07998952B2
公开(公告)日:2011-08-16
申请号:US12631144
申请日:2009-12-04
申请人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
发明人: Indu T. Bharathan , Matthew Duffey , Amy Elder , Jianping Guo , Gang Li , Dominic Reynolds , Francois Soucy , Tricia J. Vos
IPC分类号: C07D487/04 , A61K31/55
CPC分类号: C07D213/75 , A61K31/55 , A61N5/10 , C07D215/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I化合物:其中R 1,R 2,R 3,R 4,R 5和R 6如说明书中所述。 这些化合物是PLK的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08859768B2
公开(公告)日:2014-10-14
申请号:US13206671
申请日:2011-08-10
申请人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
发明人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
IPC分类号: C07D239/02 , C07D241/02 , C07D213/22 , C07D413/00 , C07D401/00 , A61K31/505 , A61K31/44 , A61K31/42 , A61K31/422 , C07D413/14 , C07D417/14 , C07D413/04
CPC分类号: A61K31/422 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2和G1如说明书中所述。 这些化合物是VPS34和/或PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120142732A1
公开(公告)日:2012-06-07
申请号:US13206671
申请日:2011-08-10
申请人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
发明人: Courtney A. Cullis , Krista E. Granger , Jianping Guo , Masaaki Hirose , Gang Li , Miho Mizutani , Tricia J. Vos
IPC分类号: A61K31/443 , C07D413/14 , A61K31/4439 , C07D413/04 , A61K31/422 , A61K31/444 , C07D405/14 , A61K31/4545 , C07D409/14 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/08 , A61P7/02 , A61P9/12 , A61P9/04 , C07D405/04
CPC分类号: A61K31/422 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2和G1如说明书中所述。 这些化合物是VPS34和/或PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US09029411B2
公开(公告)日:2015-05-12
申请号:US12321871
申请日:2009-01-26
IPC分类号: A61K31/38 , C07D333/36 , C07D409/04 , C07D333/38 , C07D333/40 , C07D409/12 , C07D417/12
CPC分类号: C07D409/04 , C07D333/38 , C07D333/40 , C07D409/12 , C07D417/12
摘要: This invention provides thiophene compounds of formula I: wherein R1, R2, R3, R4, n, p, and m are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
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