公开(公告)号：US20180223238A1

公开(公告)日：2018-08-09

申请号：US15854789

申请日：2017-12-27

Applicant: Industrial Technology Research Institute

Inventor： Ying-Wen Shen ,  Ing-Kae Wang ,  Chia-Jung Lu ,  Yea-Tzy Deng ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Hsin-Hsin Shen ,  Hsiu-Ying Wang

IPC: C12M1/00 ,  C12M1/24 ,  C12M3/04 ,  C12M1/42

CPC classification number: C12M23/52 ,  C12M3/04 ,  C12M23/08 ,  C12M23/26 ,  C12M23/40 ,  C12M23/46 ,  C12M25/00 ,  C12M35/04 ,  C12M35/06 ,  C12M41/40

Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US20210147789A1

公开(公告)日：2021-05-20

申请号：US17160405

申请日：2021-01-28

Applicant: Industrial Technology Research Institute

Inventor： Hsiu-Ying Wang ,  Ying-Wen Shen ,  Ing-Kae Wang ,  Shu-Fen Yeh ,  Wei-Zhou Yeh

IPC: C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00

Abstract: A cell recovery method including the following steps is provided. A cell culture carrier module is provided. The cell culture carrier module includes at least one cell culture carrier. The cell culture carrier is compressed into a first structure. Cell culture is performed by using the cell culture carrier exhibiting the first structure. The cell culture carrier is stretched from the first structure to a second structure. The first structure and the second structure are different structures. Cell recovery is performed by using the cell culture carrier exhibiting the second structure.

公开(公告)号：US20190203165A1

公开(公告)日：2019-07-04

申请号：US16226647

申请日：2018-12-20

Applicant: Industrial Technology Research Institute

Inventor： Ing-Kae Wang ,  Ying-Wen Shen ,  Yea-Tzy Deng ,  Den-Tai Lin ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Wei-Zhou Yeh ,  Meng-Hua Yang ,  Hsiang-Chun Hsu ,  Ying-Chun Chien

IPC: C12M1/12 ,  C12M1/40 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00

CPC classification number: C12M25/02 ,  C12M25/14 ,  C12M33/00

Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US11254902B2

公开(公告)日：2022-02-22

申请号：US16226647

申请日：2018-12-20

Applicant: Industrial Technology Research Institute

Inventor： Ing-Kae Wang ,  Ying-Wen Shen ,  Yea-Tzy Deng ,  Den-Tai Lin ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Wei-Zhou Yeh ,  Meng-Hua Yang ,  Hsiang-Chun Hsu ,  Ying-Chun Chien

IPC: C12M1/26 ,  C12M1/40 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12 ,  C12M1/34

Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US10704017B2

公开(公告)日：2020-07-07

申请号：US15854789

申请日：2017-12-27

Applicant: Industrial Technology Research Institute

Inventor： Ying-Wen Shen ,  Ing-Kae Wang ,  Chia-Jung Lu ,  Yea-Tzy Deng ,  Yu-Bing Liou ,  Sing-Ying Hsieh ,  Hsin-Hsin Shen ,  Hsiu-Ying Wang

IPC: C12M1/24 ,  C12M1/42 ,  C12M1/00 ,  C12M3/04 ,  C12M1/12 ,  C12M3/00 ,  C12M1/34

Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

公开(公告)号：US20170166859A1

公开(公告)日：2017-06-15

申请号：US14985308

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Hsiu-Ying Wang ,  Ying-Wen Shen ,  Ing-Kae Wang ,  Shu-Fen Yeh ,  Wei-Zhou Yeh

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M47/02 ,  C12M23/44 ,  C12M25/02 ,  C12M33/00

Abstract: A cell culture carrier module, a bioreactor and a cell recovery method are provided. The cell culture carrier module includes at least one cell culture carrier capable of transforming between a two dimensional structure and a three dimensional structure. The cell culture carrier exhibits the two dimensional structure in a loosened state and exhibits the three dimensional structure in a compressed state.