公开(公告)号：US20030087444A1

公开(公告)日：2003-05-08

申请号：US10021706

申请日：2001-11-05

Applicant: Industrial Technology Research Institute

Inventor： Chung-Fan Chiou ,  Shyh-Haur Su ,  Je-Ping Hu ,  Ying-Chi Chen

IPC: G01N035/02

CPC classification number: B01J19/0046 ,  B01L3/0241 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/2575

Abstract: A method and apparatus for manufacturing biochips Accordingly, the invention provides an apparatus for manufacturing a biochip from a substrate. The apparatus comprises a conveying device and a series of dispensers positioned at a series of dispensing positions above the conveying device. At least one substrate is disposed on the conveying device, and the conveying device successively moves each substrate below the series of dispensers. Each of the dispensers has a plurality of nozzles facing the substrate. Each of the nozzles dispenses a predetermined reagent at a predetermined position of the substrate; thereby, an array of reagents is dispensed on the substrate at each dispensing position. The successive movement of the substrate below the series of dispensers obtains a biochip with a high-density array of reagents disposed thereupon.

Abstract translation: 用于制造生物芯片的方法和装置因此，本发明提供了一种用于从衬底制造生物芯片的装置。 该装置包括输送装置和位于输送装置上方的一系列分配位置的一系列分配器。 至少一个基板设置在输送装置上，并且输送装置连续地将一系列分配器下方的每个基板移动。 每个分配器具有面向基板的多个喷嘴。 每个喷嘴在基板的预定位置分配预定的试剂; 从而在每个分配位置上在基板上分配一组试剂。 在一系列分配器下面的衬底的连续移动获得了设置在其上的高密度阵列的生物芯片。

公开(公告)号：US20040085388A1

公开(公告)日：2004-05-06

申请号：US10392017

申请日：2003-03-19

Applicant: Industrial Technology Research Institute

Inventor： Shyh-Haur Su ,  Mon-Da Yang ,  Jian-Chung Liou ,  Charles C. Chang

IPC: B41J002/015

CPC classification number: B41J2/2135 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00554 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00693

Abstract: An image alignment device and method for a biochip-manufacturing apparatus. The biochip-manufacturing apparatus comprises a conveying device and a plurality of dispensers. The image alignment device comprises an image pickup unit and a plurality of adjusting units. The image pickup unit is disposed on the conveying device. The conveying device conveys the image pickup unit to a predetermined position corresponding to one of the dispensers so that the image pickup obtains the image of the corresponding dispenser. Each of the adjusting units is coupled to the image pickup unit and corresponds to the dispensers respectively, and adjusts the position of the corresponding dispenser based on the image pickup unit.

Abstract translation: 一种用于生物芯片制造装置的图像对准装置和方法。 生物芯片制造装置包括输送装置和多个分配器。 图像对准装置包括图像拾取单元和多个调节单元。 图像拾取单元设置在输送装置上。 输送装置将图像拾取单元传送到与其中一个分配器相对应的预定位置，使得图像拾取器获得相应分配器的图像。 每个调节单元分别耦合到图像拾取单元并对应于分配器，并且基于图像拾取单元调节相应的分配器的位置。

公开(公告)号：US20030086828A1

公开(公告)日：2003-05-08

申请号：US10021690

申请日：2001-11-05

Applicant: Industrial Technology Research Institute

Inventor： Chung-Fan Chiou ,  Ying-Chi Chen ,  Shyh-Haur Su ,  Chih-Ping Lu ,  Ching-Yi Mao ,  Je-Ping Hu

IPC: B01L003/02

CPC classification number: B01L3/0268 ,  B01J2219/00274 ,  B01L2200/04 ,  B01L2300/021 ,  B01L2300/0838 ,  B01L2400/0433 ,  B01L2400/0442 ,  G01N35/1002 ,  G01N2035/103 ,  G01N2035/1034 ,  Y10T436/2575

Abstract: A micro-dispenser for dispensing predetermined amounts of fluids under the control of a controller. The micro-dispenser comprises a base and a high-density array of tube assemblies. The base, having a plurality of holes, is electrically connected to the controller. The tube assemblies, pre-filled with predetermined fluids, are detachably disposed in the holes and separately electrically connected to the base. The tube assemblies dispense the fluids through the base under the control of the controller. The tube assemblies are replaceable.

Abstract translation: 一种用于在控制器的控制下分配预定量的流体的微型分配器。 微型分配器包括基座和管组件的高密度阵列。 具有多个孔的底座电连接到控制器。 预先填充有预定流体的管组件可拆卸地设置在孔中并且单独地电连接到基座。 管组件在控制器的控制下通过基座分配流体。 管组件可更换。

公开(公告)号：US20030108451A1

公开(公告)日：2003-06-12

申请号：US10021598

申请日：2001-12-12

Applicant: Industrial Technology Research Institute

Inventor： Shyh-Haur Su ,  Ching-Yi Mao ,  Je-Ping Hu ,  Chung-Fan Chiou

IPC: B01L003/02

CPC classification number: B01L3/0268 ,  B01J2219/00378 ,  B01L2200/04 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0439 ,  C40B60/14 ,  Y10T436/2575

Abstract: An inkjet cartridge for dispensing a predetermined amount of reagents is provided. The inkjet cartridge comprises an inkjet print head and an array of capillary tubes. The print head is provided with a plurality of channels. The capillary tubes, filled with predetermined reagents, are disposed on the inkjet print head so as to communicate with the channels respectively and provide capillarity sufficient to prevent the reagents in the capillary tubes from leaking through the channels but not so great as to prevent the reagents in the capillary tubes from dispensing through the channels.

Abstract translation: 提供了用于分配预定量的试剂的喷墨墨盒。 喷墨墨盒包括喷墨打印头和毛细管阵列。 打印头设置有多个通道。 填充有预定试剂的毛细管分别设置在喷墨打印头上，以便分别与通道连通，并提供足以防止毛细管中的试剂泄漏通过但不太大的毛细管，以防止试剂 在毛细管中通过通道进行分配。